Autologous blood versus fibrin glue for conjunctival autograft adherence in sutureless pterygium surgery: a randomised controlled trial

Kurian, Achamma; Reghunadhan, Iodine; Nair, Kgr

doi:10.1136/bjophthalmol-2014-305028

Cited by 46 publications

(40 citation statements)

References 25 publications

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“…Fibrin tissue adhesive has been widely applied in various medical fields, including ophthalmic surgery such as vitreoretinal, glaucoma, ocular surface, cataract and refractive surgery [3,4,5,6,7,8,9,13,14,15,16,17,18]. To our knowledge, this is one of a few reports concerning the applicability of bioadhesive in ocular surface tumor surgery [5,15].…”

Section: Discussionmentioning

confidence: 99%

Surgical Reconstruction of Ocular Surface Tumors Using Fibrin Sealant Tissue Adhesive

2016

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Purpose: To evaluate the surgical outcomes of ocular surface reconstruction in corneal-conjunctival tumors using fibrin tissue adhesive. Methods: A prospective noncomparative study was performed between May 2013 and February 2015. Patients were submitted to routine surgical procedure for corneal-conjunctival tumor excision followed by amniotic membrane graft transplantation using fibrin tissue adhesive (Evicel®, Omrix Biopharmaceuticals Ltd., Israel). Results were assessed on the 1st, 7th, 15th and 30th postoperative days to analyze subjective complaints, adhesiveness and positioning of the graft, potential complications and recurrences. Results: Twenty-five eyes were analyzed (male, 14). The diagnosis after the treatment was categorized as squamous cell neoplasia, dysplasia, actinic keratosis, squamous papilloma and compound melanocytic nevus. Few significant symptoms were reported, such as mild hyperemia and ocular dyscomfort. One case developed a conjunctival granuloma which regressed after topical treatment. All grafts were successful with no displacements or retraction postoperatively. There was no clinical recurrence of the tumor in a mean time of follow-up of 11 months. Conclusion: Fibrin tissue adhesive is safe and effective in the surgery of ocular surface tumor. In this series, sutureless amniotic membrane transplantation using fibrin glue has the potential to shorten the surgical time, mitigate inflammation postoperatively and improve patient discomfort.

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Section: Discussionmentioning

confidence: 99%

Surgical Reconstruction of Ocular Surface Tumors Using Fibrin Sealant Tissue Adhesive

2016

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“…It consists of fibrovascular subconjunctival tissue with elastotic degeneration and conjunctival epithelial hypertrophy (Kim et al 2016). Traditionally the autologous graft was secured in place with sutures but in many parts of the world sutures have been replaced with tissue glue (fibrin glue) or its variations such as autologous blood (Pan et al 2011;Boucher et al 2015;Kurian et al 2015). It can affect vision by direct obstruction of the passage of light or induce corneal distortion and irregular astigmatism.…”

Section: Introductionmentioning

confidence: 99%

“…When indicated for the above reasons, surgical excision with autologous conjunctival graft is the intervention of choice with intraoperative use of an antimetabolite such as Mitomycin-C (MMC) as an adjunct, especially in recurrent cases. Traditionally the autologous graft was secured in place with sutures but in many parts of the world sutures have been replaced with tissue glue (fibrin glue) or its variations such as autologous blood (Pan et al 2011;Boucher et al 2015;Kurian et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Healing of autologous conjunctival grafts in pterygium surgery

Ghoz

El‐Alfy

Said

et al. 2018

Acta Ophthalmologica

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“…Farid et al [5] reported that the average time to recurrence was 3.13 months. Based on the simple excision of pterygium, multiple strategies and techniques have been developed to reduce the high rate of pterygium recurrence, including limbal conjunctival autograft [6], human amniotic membrane grafting [7], beta-irradiation [8], stem cell transplantation [9], mitomycin-C [10] and fibrin glue (FG) [11, 12]. However, severe complications might be induced by pterygium surgery, such as autograft dehiscence and corneal lesions [13, 14].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of fibrin glue versus sutures for attaching conjunctival autografts in pterygium surgery: a systematic review with meta-analysis and trial sequential analysis of evidence

Lan

Xiao

Wang³

et al. 2017

Oncotarget

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Previous meta-analyses have been conducted to compare the efficacy of fibrin glue (FG) versus sutures in pterygium surgery; however, additional clinical trials have since been published. Therefore, we conducted an updated meta-analysis to further explore the association between FG application in pterygium surgery, and the recurrence rate, complication rate, and surgical duration. An electronic literature search for eligible studies published before July 29, 2016 was conducted across multiple databases. Odds ratios (ORs), standardized mean difference (SMD), and 95% confidence intervals (CI) were calculated. Publication bias of the included articles was evaluated by funnel plots. Differences in recurrence rate and complication rate between the FG and suture groups were evaluated in terms of OR with 95% CI, and SMD with 95% CI were used to estimate the difference in surgical duration. Trial sequential analysis (TSA) was used to determine whether the currently available evidence was sufficient and conclusive. Twenty-four studies were included in this study. The pooled ORs for recurrence rate and complication rate were 0.35 and 1.121, respectively. The pooled SMD for surgical duration was −4.142. The TSA results indicated that evidence of the effect was sufficient in the recurrence group and surgical duration group. Although there was no difference in complication rate between FG and sutures, the apparent advantages of FG over sutures are shorter surgical duration and greater reduction in the recurrence rate of pterygium.

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Autologous blood versus fibrin glue for conjunctival autograft adherence in sutureless pterygium surgery: a randomised controlled trial

Abstract: Clinical Trial Registry, India: CTRI/2013/06/003764 and UTN: U1111-1140-6572.

Cited by 46 publications

References 25 publications

Surgical Reconstruction of Ocular Surface Tumors Using Fibrin Sealant Tissue Adhesive

Surgical Reconstruction of Ocular Surface Tumors Using Fibrin Sealant Tissue Adhesive

Healing of autologous conjunctival grafts in pterygium surgery

Efficacy of fibrin glue versus sutures for attaching conjunctival autografts in pterygium surgery: a systematic review with meta-analysis and trial sequential analysis of evidence

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