Autologous Bone Marrow Concentrate (Mononuclear Stem Cell) Therapy in the Treatment of Oral Submucous Fibrosis

Sankaranarayanan, Seshadri; Kailasam, S; Elangovan, Shreehari; Ravi, VR; Sarkar, Sonali

doi:10.5005/jp-journals-10011-1329

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…Additionally, the latest advancements in OSMF treatment include stem cell therapy. Sankaranarayanan et al conducted a significant study assessing the function improvement and sustainability of stem cell therapy results over a five-year follow-up, revealing substantial improvements in mucosal suppleness, reduction in burning sensation, and increased mouth opening (43) The surgical management of OSMF is multifaceted, incorporating a range of techniques from fibrotomy and adjunctive therapies to advanced reconstructive procedures and emerging treatments like stem cell therapy and omega-3 supplementation. Each method offers unique benefits and challenges, and the choice of treatment is contingent on the individual patient's condition and the severity of OSMF.…”

Section: Discussionmentioning

confidence: 99%

Oral Submucous Fibrosis: A Review on Different Treatment Modalities

Khatoon,

Abbasi,

Ilyas

et al. 2023

JHRR

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Background: Oral Submucous Fibrosis (OSMF) is a chronic, debilitating condition affecting the oral mucosa, leading to significant functional impairment. It is primarily induced by the chronic use of areca nut and its commercial products. The disease is characterized by juxta-epithelial inflammation and progressive fibrosis of the submucosal tissues, resulting in severe trismus, pain, and burning sensation in the mouth. Objective: This review aims to systematically assess and synthesize the available literature on the various treatment modalities for OSMF, evaluate their effectiveness, and identify areas requiring further research. Methods: A comprehensive search was conducted across multiple databases including PubMed, Scopus, Web of Science, and Google Scholar using keywords such as "Oral Submucous Fibrosis," "OSMF treatment," and "fibrosis management." Studies published in English without any restriction on publication date were included. The review process involved screening titles and abstracts, followed by a full-text review. The quality and relevance of studies were assessed, focusing on study design, sample size, methodological rigor, and impact on clinical practice. Quantitative data were extracted and synthesized where available. Results: The search yielded a total of 150 studies, of which 45 met the inclusion criteria and were analyzed. Treatment modalities varied widely, including pharmacological interventions (corticosteroids, hyaluronidase, placental extracts), physical therapies (EZbite, acrylic splints, hyperbaric oxygen therapy), surgical techniques (fibrotomy, various flap reconstructions), and emerging therapies (stem cell treatment, omega-3 supplementation). Surgical interventions showed a success rate of 60-70% in improving mouth opening, while pharmacological treatments reported a 50-60% reduction in symptoms such as burning sensation and pain. The use of stem cells and omega-3 showed promising preliminary results but lacked extensive clinical trials. Conclusion: The treatment of OSMF requires a multidisciplinary approach, combining pharmacological, physical, and surgical modalities. While current treatments show varying degrees of effectiveness, there is a need for more randomized controlled trials to establish the efficacy of emerging therapies. Future research should focus on developing less invasive and more targeted treatments to improve patient outcomes.

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Section: Discussionmentioning

confidence: 99%

Oral Submucous Fibrosis: A Review on Different Treatment Modalities

Khatoon,

Abbasi,

Ilyas

et al. 2023

JHRR

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“…Stem cell therapy is primarily aimed at neoangiogenesis by releasing cytokines and growth factors. This therapy may help stimulate resident tissue and transform it into new fibroblasts (Seshadri et al, 2013). Gupta and Jawanda (2021) also reported that this therapy has been proven to be effective in the treatment of OSMF by administering autologous bone marrow stem cell injections in the area of the lesion to decrease the progression of fibrosis because of increased angiogenesis, which ultimately improved the symptom of mouth opening.…”

Section: Current Treatment Regimenmentioning

confidence: 99%

Plant leads for mitigation of oral submucous fibrosis: Current scenario and future prospect

2023

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The aim of this review is to enumerate medicinal plants and their bioactive compounds that may become potential leads in the mitigation of oral submucous fibrosis (OSMF) in the forthcoming future. It is focused on pathophysiology, risk factors, current treatment regimen, potential plant leads, and future therapies for OSMF. Data were extracted from a vast literature survey by using SciFinder, Web of Science, Google Scholar, and PubMed search engines with relevant keywords. Upon literature survey, we found that the phytochemical ‘arecoline’ present in the areca nut is the main causative agent of OSMF condition. Currently, OSMF is treated by immunomodulatory and anti‐inflammatory agents such as corticosteroids, enzymes (hyaluronidase, chymotrypsin, and collagenase), anti‐inflammatory mediators (isoxsuprine and pentoxifylline), dietary supplements (vitamins, antioxidants, and micronutrients), and anti‐fibrotic cytokines like interferon‐gamma that provides short‐term symptomatic relief to OSMF patients. However, some plant leads have been proven effective in alleviating symptoms and mitigating OSMF, which ultimately improves the quality of OSMF patients' life. We concluded that plant drugs like lycopene, curcumin, Aloe vera, colchicine, and Glycyrrhiza glabra are effective against OSMF in various in vitro and/or clinical studies and are being used by modern and traditional practitioners.

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“…Mononuclear stem cell therapy: The effectiveness of stem cell therapy in the treatment of OSMF was examined in a 2013 study by Seshadri et al, who assessed the improvement in function and the sustainability of the result with a five-year follow-up [42]. Three of the seven patients received stem cell treatments using the ficol method, while four received stem cell treatments using point-of-care delivery systems [43].…”

Section: Surgerymentioning

confidence: 99%

Oral Submucous Fibrosis: A Review of the Current Concepts in Management

Chhabra,

Sune,

Reche

2023

Cureus

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Oral submucous fibrosis (OSMF) is a precancerous disorder of the submucosa that causes inflammation and progressive fibrosis, leading to pronounced stiffness and trismus. Chewing betel nuts is a significant risk factor for OSMF in India. Arecoline from betel nuts and copper, which causes fibroblast dysfunction and the development of fibrotic bands, are the main components of betel quid. OSMF is distinguished by fibrosis in the submucosal region, which affects the majority of the oral cavity and results in advanced lockjaw due to rigidity in the lips, pharynx, cheeks, and upper third of the oesophageal canal, which progresses to dysphagia. The prevalence of OSMF is rising, particularly among younger generations, as more commercially available areca nut products like gutka (chewing tobacco) and others are being introduced. The severity of OSMF develops as the practice continues and is permanent. It also persists even after chewing has been stopped. The hallmark of oral submucous fibrosis (OSF) is abnormal collagen deposition. It is a precancerous condition and progresses to malignant tumours. Symptoms include ulcers, xerostomia, submucous fibrosis, burning sensation, and a reduction in mouth opening. Each of these drastically reduces the patient's quality of life. In the past, many treatment modalities have been tried but none of them has resulted in a cure for the disease. The primary focus of the treatment is to reduce the signs and symptoms so that the patient can have a better quality of life. Along with principles, conservative, medical, and surgical management issues have also been covered.

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Autologous Bone Marrow Concentrate (Mononuclear Stem Cell) Therapy in the Treatment of Oral Submucous Fibrosis

Cited by 5 publications

References 18 publications

Oral Submucous Fibrosis: A Review on Different Treatment Modalities

Oral Submucous Fibrosis: A Review on Different Treatment Modalities

Plant leads for mitigation of oral submucous fibrosis: Current scenario and future prospect

Oral Submucous Fibrosis: A Review of the Current Concepts in Management

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