Autologous Breast Reconstruction: The Vanderbilt Experience (1998 to 2005) of Independent Predictors of Displeasing Outcomes

Obese Women Experience Fewer Complications after Oncoplastic Breast Repair following Partial Mastectomy Than after Immediate Total Breast Reconstruction

“…[33][34][35][36][37][38][39] Among breast reconstruction patients, obesity has been shown to increase complication rates in both implant-based and autologous immediate breast reconstruction. 1,2,4,[6][7][8]14,[40][41][42][43][44] The overall complication rate in our obese patients undergoing oncoplastic breast reconstruction and immediate breast reconstruction was comparable to other studies 41,45 ; however, no single-center studies exist with sufficiently powered logistic regression analysis to evaluate specific predictive factors between oncoplastic breast reconstruction and immediate breast reconstruction complications among the obese. In a 2010 study, Losken et al showed that rates of complications and revision operations were significantly higher for patients following skin-sparing mastectomy and immediate breast reconstruction than for women with macromastia who underwent oncoplastic breast reconstruction.…”

Surgical Site Infections after Free Flap Breast Reconstruction: An Analysis of 2,899 Patients from the ACS-NSQIP Datasets

“…18 In contrast, Greco et al conducted a retrospective review of 200 TRAM and latissimus dorsi flaps in 180 patients and found that obese patients were more likely to experience clinically significant flap infections (24.0 vs. 0%, p < 0.01). 19 We note that both Chang et al and Greco et al conducted their reviews on patients at a single institution-MD Anderson and Vanderbilt University (Nashville, TN), respectively. In contrast, the ACS-NSQIP is a national, heterogeneous database, which possibly erases any regionally based effects obesity may have on wound infections.…”

The response to neoadjuvant chemotherapy predicts clinical outcome and increases breast conservation in advanced breast cancer

“…Mastectomy has a complication rate ranging from 14%–64% which can be significantly lowered with lumpectomy. 17,18 In this cohort, patients that were identified for treatment at stage II were the most likely to become eligible for BCT. A recent study has shown improved clinical outcomes for patients with triple negative breast cancer who undergo lumpectomy instead of mastectomy 16 .…”