2003
DOI: 10.2106/00004623-200302000-00001
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Autologous Chondrocyte Implantation and Osteochondral Cylinder Transplantation in Cartilage Repair of the Knee Joint

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Cited by 769 publications
(618 citation statements)
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References 30 publications
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“…Transplantation of osteochondral cylinders (autograft, allograft) have been used with reported success [8,21,22]. Using the OATS technique, Laprell and Petersen [21] found a normal function in 12 of 35 patients, a nearly normal function in 14 of 35 and an abnormal function in 3 of 35 after a mean follow-up of 8.1 years.…”
Section: Discussionmentioning
confidence: 99%
“…Transplantation of osteochondral cylinders (autograft, allograft) have been used with reported success [8,21,22]. Using the OATS technique, Laprell and Petersen [21] found a normal function in 12 of 35 patients, a nearly normal function in 14 of 35 and an abnormal function in 3 of 35 after a mean follow-up of 8.1 years.…”
Section: Discussionmentioning
confidence: 99%
“…However, this technique possesses many inherent limitations including donor site morbidity, limited quantity of suitable host tissue as well as the difficulty in correctly matching the topography of the graft with the healthy tissue surrounding the defect site [5]. Issues including incomplete integration between the host tissue and graft tissue [6] and the degradation of the graft tissue are often observed [7]. Tissue Engineering (TE) strategies may provide significant advantages compared to these more traditional clinical treatment methods.…”
Section: Introductionmentioning
confidence: 99%
“…9 Inadequate bonding of the graft cartilage to surrounding tissue is a common finding noted in second-look arthroscopy in clinical subjects 10 as well as histological analysis in animal models. 11,12 Synthetic tissue-engineered multiphasic implants consisting of distinct cartilage and bone layers are an area of increasing research interest. This treatment method has the potential to restore the anatomical osteochondral junction without iatrogenic injury at donor sites and with the flexibility to treat larger lesions.…”
mentioning
confidence: 99%