Autologous Chondrocyte Implantation in the Knee Joint: Open Compared with Arthroscopic Technique

Ferruzzi, A.; Buda, Roberto; Faldini, Cesare; Vannini, Francesca; Caprio, Francesco Di; Luciani, Deianira; Giannini, Sandro

doi:10.2106/jbjs.h.00633

Cited by 100 publications

(91 citation statements)

References 19 publications

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“…(Appendix 2). However, findings from the studies also showed no difference in patient-reported outcome scores between matrix-assisted chondrocyte transplantation and autologous chondrocytes transplantation [3,10,14,23,44].…”

Section: Studies Comparing Microfracture Chondrocyte Transplantationmentioning

confidence: 94%

What Is the Effect of Matrices on Cartilage Repair? A Systematic Review

Wylie

Hartley

Kapron

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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Background Articular cartilage has minimal endogenous ability to undergo repair. Multiple chondral restoration strategies have been attempted with varied results. Questions/purposes The purpose of our review was to determine: (1) Does articular chondrocyte transplantation or matrix-assisted articular chondrocyte transplantation provide better patient-reported outcomes scores, MRI morphologic measurements, or histologic quality of repair tissue compared with microfracture in prospective comparative studies of articular cartilage repair; and (2) which available matrices for matrix-assisted articular chondrocyte transplantation show the best patient-reported outcomes scores, MRI morphologic measurements, or histologic quality of repair tissue? Methods We conducted a systematic review of PubMed, CINAHL, and MEDLINE from March 2004 to February 2014 using keywords determined to be important for articular cartilage repair, including ''cartilage'', ''chondral'', ''cell source'', ''chondrocyte'', ''matrix'', ''augment'', ''articular'', ''joint'', ''repair'', ''treatment'', ''regeneration'', and ''restoration'' to find articles related to cell-based articular cartilage repair of the knee. The articles were reviewed by two authors (JDW, MKH), our study exclusion criteria were applied, and articles were determined to be relevant (or not) to the research questions. The Methodological Index for Nonrandomized Studies (MIN-ORS) scale was used to judge the quality of nonrandomized manuscripts used in this review and the Jadad score was used to judge the quality of randomized trials. Seventeen articles were reviewed for the first research question and 83 articles were reviewed in the second research question from 301 articles identified in the original systematic search. The average MINORS score was 9.9 (62%) for noncomparative studies and 16

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Section: Studies Comparing Microfracture Chondrocyte Transplantationmentioning

confidence: 94%

What Is the Effect of Matrices on Cartilage Repair? A Systematic Review

Wylie

Hartley

Kapron

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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“…Owing to tissue engineering, biodegradable scaffolding for cell support and proliferation such as Hyalograft 1 C (Fidia Advanced Biopolymers, Abano Terme, Italy) or matrix-induced autologous chondrocyte implantation has been proposed, permitting entirely arthroscopic autologous chondrocyte implantation with a substantial reduction in surgical morbidity [4,19,22]. Nevertheless, the need for two operations and high costs remain drawbacks of autologous chondrocyte implantation [10,24,25,29,30,52,61].…”

Section: Introductionmentioning

confidence: 99%

One-step Bone Marrow-derived Cell Transplantation in Talar Osteochondral Lesions

Giannini

Buda

Vannini

et al. 2009

Clin Orthop Relat Res

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275

297

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“…MACI relies on the use of biomaterials seeded with chondrocytes as carriers and scaffolds for cell growth to generate new, functional, articular tissue. Over the years, a number of MACI related products have been commercialized for routine clinical application (17)(18)(19)(20). The CaReS®-system used in the current case series is composed of autologous chondrocytes seeded on three-dimensional collagen I hydrogels.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Large Osteochondral Defects with Spongiosaplasty and Collagen Type I Hydrogel-Based Autologous Chondrocyte Implantation

Reichert¹,

Fensky²,

Siebenlist³

et al. 2017

JESO

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Clinical data suggest that the reconstruction of large osteochondral defects requires application of osseous cylinders to augment the bony defect. This prospective case series investigates the clinical outcome after impaction grafting as an alternative to osseous cylinder transplantation to reconstruct the subchondral bone plate.We report on three patients with large osteochondral defects of the femoral condyle (averaging 10.9 cm²) resulting from osteochondritis dissecans or osteonecrosis. Defects were treated with spongiosaplasty followed by matrix-based autologous chondrocyte implantation (MACI) using a collagen-I-hydrogel. The patients were examined at 3, 6, 12, 24, 36, 48, and 60 months after surgery. The follow-up included radiographs, MRI, patient/doctor assessment as well as the IKDC-2000 evaluation package (IKDC score).At final follow-up, all three patients were satisfied with the long-term outcome since free of pain. Their functional and activity levels were back to normal, which was also reflected in the obtained IKDC-scores. Radiographic and MRI imaging showed complete reconsolidation of the subchondral osseus defects and excellent integration of the implanted collagen based matrix with the surrounding hyaline cartilage. Therefore, autologous spongiosaplasty as an alternative to the transplantation of osseous cylinders is a sufficient technique to reconstruct the subchondral bone plate in patients with large osteochondral defects.

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Autologous Chondrocyte Implantation in the Knee Joint: Open Compared with Arthroscopic Technique

Cited by 100 publications

References 19 publications

What Is the Effect of Matrices on Cartilage Repair? A Systematic Review

What Is the Effect of Matrices on Cartilage Repair? A Systematic Review

One-step Bone Marrow-derived Cell Transplantation in Talar Osteochondral Lesions

Treatment of Large Osteochondral Defects with Spongiosaplasty and Collagen Type I Hydrogel-Based Autologous Chondrocyte Implantation

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