Autologous Chondrocyte Transplantation for Treating Cartilage Defects of the Talus

Baums, Mike H.; Heidrich, Gabert; Schultz, W.; Steckel, Hanno; Kahl, Enrico; Klinger, Hans-Michael

doi:10.2106/jbjs.e.00033

Cited by 134 publications

(91 citation statements)

References 22 publications

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“…However, the surgeons have to be aware of potentially related problems. First, it is essential to be conscious of a proper level to avoid violating the articular surface as well as to gain optimal visibility of the defect [40] . Second, one must focus on a …”

Section: Tissue Transplantationmentioning

confidence: 99%

“…The use of fresh osteochondral allografts is a different technique especially designed to reconstruct massive osteochondral defects that have substantial loss or cystic degeneration of subchondral bone [40] (Figure 5). Indications for choosing this method for reconstruction are similar to those for osteochondral autologous transplantation, but without limitations based on size [36] .…”

Section: Osteochondral Allograft Transplantationmentioning

confidence: 99%

“…Autologous chondrocyte transplantation (ACT) is a cell-based, two-stage procedure that involves the transplantation of viable and cultured chondrocytes into a defect. In the first step, cartilaginous material is harvested from the knee or the ankle itself [10,40] . In some cases, the cartilage was harvested from a detached osteochondral fragment without any reported adverse effect on the chondrocytes' viability [60] .…”

mentioning

confidence: 99%

“…Indications and contraindications are summarised in Table 1. A method using a periosteum-covered ACT is called the first generation of this technique. A periosteal flap is harvested, i.e., from the distal part of the tibia, and then placed over the defect with the cambium layer facing toward the aforementioned prepared bed [40,61] . Then, the cultured cell suspension is injected beneath the sutured flap.…”

mentioning

confidence: 99%

“…Analysing of the literature reveals various trials of ACT of the talus [4,40,43,63,64] . Although, many of the reports publicised promising results, the available evidence is of poor quality.…”

mentioning

confidence: 99%

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Cartilage repair techniques of the talus: An update

Baums¹

2014

WJO

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Symptomatic chondral or osteochondral defects of the talus reduce the quality of life of many patients. Although their pathomechanism is well understood, it is well known that different aetiologic factors play a role in their origin. Additionally, it is well recognised that the talar articular cartilage strongly differs from that in the knee. Despite this fact, many recommendations for the management of talar cartilage defects are based on approaches that were developed for the knee. Conservative treatment seems to work best in paediatric and adolescent patients with osteochondritis dissecans. However, depending on the size of the lesions, surgical approaches are necessary to treat many of these defects. Bone marrow stimulation techniques may achieve good results in small lesions. Large lesions may be treated by open procedures such as osteochondral autograft transfer or allograft transplantation. Autologous chondrocyte transplantation, as a restorative procedure, is well investigated in the knee and has been applied in the talus with increasing popularity and promising results but the evidence to date is poor. The goals of the current article are to summarise the different options for treating chondral and osteochondral defects of the talus and review the available literature.

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Section: Tissue Transplantationmentioning

confidence: 99%

Section: Osteochondral Allograft Transplantationmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Cartilage repair techniques of the talus: An update

Baums¹

2014

WJO

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Posterior talar process as a suitable cell source for treatment of cartilage and osteochondral defects of the talus

Correia

Silva‐Correia

Pereira

et al. 2015

J Tissue Eng Regen Med

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Osteochondral defects of the ankle are common lesions affecting the talar cartilage and subchondral bone. Current treatments include cell-based therapies but are frequently associated with donor-site morbidity. Our objective is to characterize the posterior process of the talus (SP) and the os trigonum (OT) tissues and investigate their potential as a new source of viable cells for application in tissue engineering and regenerative medicine. SP and OT tissues obtained from six patients were characterized by micro-computed tomography and histological, histomorphometric and immunohistochemical analyses. Proliferation and viability of isolated cells were evaluated by MTS assay, DNA quantification and live/dead staining. The TUNEL assay was performed to evaluate cell death by apoptosis. Moreover, the production of extracellular matrix was evaluated by toluidine blue staining, whereas cells phenotype was investigated by flow cytometry. Characterization of ankle explants showed the presence of a cartilage tissue layer in both SP and OT tissues, which represented at least 20%, on average, of the explant. The presence of type II collagen was detected in the extracellular matrix. Isolated cells presented a round morphology typical of chondrocytes. In in vitro studies, cells were viable and proliferating for up to 21 days of culture. No signs of apoptosis were detected. Flow-cytometry analysis revealed that isolated cells maintained the expression of several chondrocytic markers during culture. The results indicated that the SP and OT tissues were a reliable source of viable chondrocytes, which could find promising applications in ACI/MACI strategies with minimal concerns regarding donor zone complications. Copyright © 2015 John Wiley & Sons, Ltd.

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Cartilage Repair, Replacement, and Regenerative Strategies for Osteochondral Lesions of the Talus

Adams

Parekh

Solminihac

et al. 2013

Developing Insights in Cartilage Repair

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Autologous Chondrocyte Transplantation for Treating Cartilage Defects of the Talus

Abstract: The promising clinical results of this study suggest that autologous chondrocyte transplantation is an effective and safe way to treat symptomatic osteochondral defects of the talus in appropriately selected patients.

Cited by 134 publications

References 22 publications

Cartilage repair techniques of the talus: An update

Cartilage repair techniques of the talus: An update

Posterior talar process as a suitable cell source for treatment of cartilage and osteochondral defects of the talus

Cartilage Repair, Replacement, and Regenerative Strategies for Osteochondral Lesions of the Talus

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