Autologous cytolytic T lymphocytes recognize a MAGE‐1 nonapeptide on melanomas expressing HLA‐Cw* 1601

Bruggen, Pierre van der; Szikora, Jean-Pierre; Boël, Pascale; Wildmann, Claude; Somville, Michel; Sensi, Marialuisa; Boon, Thierry

doi:10.1002/eji.1830240930

Cited by 200 publications

(12 citation statements)

References 56 publications

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“…Octapeptide, VRFFFPSL, was not recognized (data not shown). This result is in the same range as for other MAGE‐A1 antigenic peptides: from ∼0.1 to ∼25 n M ( 11, 13, 15).…”

supporting

confidence: 76%

“…MAGE‐A1 is expressed in esophageal carcinomas (53%), non‐small cell lung carcinomas (49%), and metastatic melanomas (48%) ( 10). CTL isolated from two melanoma patients have been found to recognize MAGE‐A1 peptides presented by HLA‐A1, B37, or Cw16 ( 11–13). Synthetic peptides have also been used to stimulate T cells and this has led to the identification of a MAGE‐A1 epitope presented by HLA‐A24 ( 14).…”

mentioning

confidence: 99%

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A MAGE‐A1 peptide is recognized on HLA‐B7 human tumors by cytolytic T lymphocytes

Luiten

Bruggen

2000

Tissue Antigens

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Antigens encoded by MAGE genes are of particular interest for cancer immunotherapy because of their strict tumoral specificity and because they are shared by many tumors. MAGE antigenic peptides are currently used in therapeutic vaccination trials. The identification of additional antigenic peptides is likely to be important for the future of these clinical trials in order to increase the number of patients eligible for these vaccinations and to analyze in detail the T-cell response of vaccinated patients. We describe here the isolation of a cytolytic T lymphocyte (CTL) clone which recognizes a new MAGE-A1 peptide, RVRFFFPSL (MAGE-A1(289-297)), which is presented by HLA-B7. This CTL clone lysed HLA-B7 tumor cells expressing MAGE-A1. HLA-B7 is expressed by approximately 20% of Caucasians

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“…Octapeptide, VRFFFPSL, was not recognized (data not shown). This result is in the same range as for other MAGE‐A1 antigenic peptides: from ∼0.1 to ∼25 n M ( 11, 13, 15).…”

supporting

confidence: 76%

mentioning

confidence: 99%

A MAGE‐A1 peptide is recognized on HLA‐B7 human tumors by cytolytic T lymphocytes

Luiten

Bruggen

2000

Tissue Antigens

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“…To generate progressive deletions from the 3′ end of cDNA 668, and thereby obtain a large number of truncated cDNA clones, we used the Erase-a-base System ( Promega , Madison, WI) as described ( 28 , 29 ).…”

Section: Methodsmentioning

confidence: 99%

A CASP-8 Mutation Recognized by Cytolytic T Lymphocytes on a Human Head and Neck Carcinoma

Mandruzzato

Brasseur

Andry

et al. 1997

The Journal of Experimental Medicine

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291

153

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Of the antigens recognized on human tumors by autologous cytolytic T lymphocytes, all those defined thus far have been identified on melanoma or renal cell carcinoma. We report here the identification of an antigen recognized by autologous cytolytic T lymphocytes on a human squamous cell carcinoma of the oral cavity. The antigen is encoded by a mutated form of the CASP-8 gene. This gene, also named FLICE or MACH, codes for protease caspase-8, which is required for induction of apoptosis through the Fas receptor and tumor necrosis factor receptor-1. The mutation, which was found in the tumor cells but not in the normal cells of the patient, modifies the stop codon and adds an Alu repeat to the coding region, thereby lengthening the protein by 88 amino acids. The ability of the altered protein to trigger apoptosis appears to be reduced relative to the normal caspase-8. The antigenic peptide is a nonamer presented by HLA-B*3503. The five last amino acids are encoded by the extension of the reading frame caused by the mutation. This, together with previous observations of CDK4 and β-catenin mutations, suggests that a significant fraction of the point mutations generating a tumor antigen also play a role in the tumoral transformation or progression.

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“…CT genes were first defined as a group of tumor antigens that elicit a cytosolic T cell response and are expressed in male germ cells in the testis and various malignancies [63][64][65]. The first CT antigen identified was melanoma antigen 1 (MAGEA-1) [66].…”

Section: Cancer Testis (Ct) Genesmentioning

confidence: 99%

The Role of the Meiotic Component in Reproduction of B-RAF-Mutated Melanoma: A Review and “Brainstorming” Session

Pjanova¹,

Vainshelbaum²,

Salmiņa³

et al. 2021

Melanoma

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The ectopic expression of cancer testis (CT) antigens and classic meiotic genes is characteristic and a hallmark of poor prognosis of melanoma disease. Here the potential mechanisms of meiotic influence on the cell and life cycle of malignant melanoma are reviewed in the genetic, epigenetic, and evolutionary aspects. The involved mutant B-RAF and N-RAS-induced senescence may be reversed by reprogramming, with stemness linked to meiotic landscape, possibly induced by DNA double-strand breaks at the mutual telomere hot spots. The induced by senescence mitotic slippage (reset of interphase from arrested metaphase) and resulting polyploidy trigger the meiotic ploidy cycle to function for effective DNA recombination repair, genome reduction, and escape of survivors, which enter the mitotic cycle again. The aberrant meiotic pathway in cancer is reviewed in the ancestral asexual variants; inverted meiosis is possible. The conundrum of cancer aneuploidy paradox, selection of fit clones, and the Muller's Ratchet of inevitable accumulation of harmful mutations is discussed. The bioinformatic study of the densely connected protein interaction network of CT antigen expressed genes revealed the melanomagenesis attractor composed of PRAME and small MAGEA group in primary tumors as compared with B-RAF-mutant nevi, restructured stemness network; invasive melanoma further displays the leading role of SPANX CT antigen group; meiotic genes are expressed in all three tissue cohorts.

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Autologous cytolytic T lymphocytes recognize a MAGE‐1 nonapeptide on melanomas expressing HLA‐Cw* 1601

Cited by 200 publications

References 56 publications

A MAGE‐A1 peptide is recognized on HLA‐B7 human tumors by cytolytic T lymphocytes

A MAGE‐A1 peptide is recognized on HLA‐B7 human tumors by cytolytic T lymphocytes

A CASP-8 Mutation Recognized by Cytolytic T Lymphocytes on a Human Head and Neck Carcinoma

The Role of the Meiotic Component in Reproduction of B-RAF-Mutated Melanoma: A Review and “Brainstorming” Session

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