Autologous Fat Graft for the Treatment of Sighted Posttraumatic Enophthalmos and Sunken Upper Eyelid

Chen, Hui; Zhang, Qian; Qiu, Qiu; Yang, Zhenglin

doi:10.1097/iop.0000000000001028

Cited by 15 publications

(10 citation statements)

References 35 publications

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“…In human medicine, only a few studies estimated the amount of fat to be injected before the retrobulbar filling [7,8]. In others, the amount of autologous fat to be injected was at the clinician's discretion according to the aesthetic improvement achieved [9,[11][12][13]. Its lack of precision may be responsible for early diplopia and unsatisfactory aesthetic results requiring additional injections [7].…”

Section: Discussionmentioning

confidence: 99%

“…In our study, the volume to be injected was estimated by formulae proposed by Greco et al [26] to calculate the retrobulbar cone volume using CT. This method has proved to be effective; however, for in vivo inoculations, considering that a reabsorption rate of up to 30-40% of the injected autologous fat is expected in a few weeks, this loss must have to be taken into account; otherwise, additional inoculations could be necessary [7][8][9].…”

Section: Discussionmentioning

confidence: 99%

“…The inoculation of fat within the extraconal space can cause a slight swelling of the eyelids, inadequate cranial displacement of the eyeball and post-operative transitory pain. However, according to the literature, extraconal migration of autologous fat does not alter the function of extraocular muscles, optic vessels, and nerves [7,9,11,13]. In human medicine, hard materials such as hydroxyapatite, cartilage, silicone or glass beads have been implanted in the orbit for the same purpose.…”

Section: Discussionmentioning

confidence: 99%

“…In human medicine, autologous fat intraconal injection (retrobulbar lipofilling) for enophthalmos resolution, mainly resulting from blow-out fractures or tumor resection, is well-described with excellent results and a low complication rate [7][8][9][10][11][12][13]. Among diagnostic imaging modalities, magnetic resonance imaging could provide detailed information regarding the nature and extent of concurrent soft tissue injuries within the retrobulbar space [14,15].…”

Section: Introductionmentioning

confidence: 99%

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Retrobulbar Filling for Enophthalmos Treatment in Dogs: Technique, Description and Computed-Tomographic Evaluation. Preliminary Cadaveric Study

Costanza¹,

Meomartino²,

Lamagna

et al. 2023

Veterinary Sciences

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A new therapeutic approach for enophthalmos may be retrobulbar lipofilling. This study aims to standardize the intraconal filling technique and to evaluate the degree of eyeball displacement by computed tomography (CT). Skull CT was performed on six dog cadavers before and after intraconal injection of two 5% iodinated, viscoelastic solutions, one per eye, using an ultrasound-guided supratemporal approach. The volume to be injected was calculated using formulas for retrobulbar cone anesthesia. After CT, the dogs underwent necropsy and histopathology to evaluate damages that eventually occurred to retrobulbar structures. Eyeball displacement was estimated using two CT-based methods, named M1 and M2. The Wilcoxon signed-rank test revealed no significant difference between the two injected materials in both M1 (p > 0.99), and M2 (lateral p = 0.84 and rostral p = 0.84 displacement). A statistically significant difference was found between the pre- and post-injection group M1 (p = 0.002), M2 (p = 0.004) for the lateral and (p = 0.003) for rostral displacement. Although the slight eyeball displacement, the retrobulbar filling can lead to enophthalmos resolution. Compared to M1, the M2 method has better-defined anatomical landmarks. Further, preclinical in vivo studies are necessary to assess retrobulbar filling efficacy and safety.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Retrobulbar Filling for Enophthalmos Treatment in Dogs: Technique, Description and Computed-Tomographic Evaluation. Preliminary Cadaveric Study

Costanza¹,

Meomartino²,

Lamagna

et al. 2023

Veterinary Sciences

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“…Autogenous fat is viewed as the most natural and safest noninvasive filling material [6,7] because of its little rejection reaction and perfect fusion with patients themselves. Research showed that autogenous fat filling is widely adopted in the treatment of the sag of upper eyelid with little trauma, no rejection [8], and high security. is method can be applied not only in the treatment of the sag of upper eyelid but also in the filling treatment of other parts of the face [9,10].…”

Section: Introductionmentioning

confidence: 99%

Removal of Autogenous Fat Filling in Double Eyelid Operation by Artificial Intelligence (AI) Algorithm-Based Computerized Tomography (CT) Image Features

Fang

Sui²,

Liang

2022

Scientific Programming

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The effect of autogenous fat filling was evaluated by computerized tomography (CT) image features based on the symmetric extended convolutional residual network image denoising algorithm in this research, and the pathological examination was conducted for the lesions of patients with complications. The examination provided more valid research basis for the clinical application of autogenous fat filling. 60 patients who received double eyelid operation were selected as the research objects, and the patients were randomly divided into the control group and the experimental group, where each group included 30 cases. The conventional double eyelid operation was adopted in treating the cases in the control group, while autogenous fat filling was adopted in the treatment of the cases in the experimental group. All patients in two groups were examined by CT images based on the symmetric extended convolutional residual network image denoising algorithm, and the therapeutic effects on patients in two groups and the evaluation of complications were compared. Next, the lesions of the complications of patients in the experimental group were examined pathologically. Besides, the efficacy and security of the pathological examination were assessed. The result showed that the values of peak signal-to-noise ratio (PSNR) and structural similarity (SSIM) (σ (noise level) = 60 : 24.78 dB, 0.7022) in different noise images of the artificial intelligence algorithm adopted in the research were obviously higher than those obtained by the convolutional neural network (CNN) and deep convolutional neural network (DCNN) algorithms (P < 0.05). The therapeutic efficacy of patients in the experimental group was higher than that in the control group (68.67% vs 60%). In addition, eyelid swelling scoring, double eyelid line width, and upper eyelid muscle strength of patients in the experimental group were all better than those of patients in the control group (P < 0.05). Besides, the incidence of complications (10%) of patients in the experimental group was significantly lower than that (30%) of patients in the control group. The pathological results of patients in the experimental group demonstrated that the lesion tissues might denature in future. As a result, the CT image processing of the algorithm adopted in this research could denoise effectively, and PSNR and SSIM values were high. In terms of the treatment by double eyelid operation, autogenous fat filling was effective, noninvasive, simple and resulted in low incidence of complications with a certain degree of security.

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Fat Grafting as an Ancillary Treatment for Burns, Other Complex Wounds, and Their Sequelae

Piccolo,

de Paula Pìccolo

et al. 2023

Fat Transfer in Plastic Surgery

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Autologous Fat Graft for the Treatment of Sighted Posttraumatic Enophthalmos and Sunken Upper Eyelid

Cited by 15 publications

References 35 publications

Retrobulbar Filling for Enophthalmos Treatment in Dogs: Technique, Description and Computed-Tomographic Evaluation. Preliminary Cadaveric Study

Retrobulbar Filling for Enophthalmos Treatment in Dogs: Technique, Description and Computed-Tomographic Evaluation. Preliminary Cadaveric Study

Removal of Autogenous Fat Filling in Double Eyelid Operation by Artificial Intelligence (AI) Algorithm-Based Computerized Tomography (CT) Image Features

Fat Grafting as an Ancillary Treatment for Burns, Other Complex Wounds, and Their Sequelae

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