Autologous Fat Graft in Postmastectomy Pain Syndrome

Caviggioli, Fabio; Maione, Luca; Forcellini, Davide; Klinger, Francesco; Klinger, Marco

doi:10.1097/prs.0b013e31821e70e7

Cited by 151 publications

(145 citation statements)

References 20 publications

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“…Histologic examination showed patterns of new collagen deposition, local hypervascularity, dermal hyperplasia, and a high correspondence to healthy tissues [3]. The promising results obtained with burn scars led us to extend the use of lipostructure for several pathologic conditions requiring tissue remodeling [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Cell Number, Viability, Phenotypic Profile, Clonogenic, and Proliferative Potential of Adipose-Derived Stem Cell Populations Between Centrifuged and Noncentrifuged Fat

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Comparison of Cell Number, Viability, Phenotypic Profile, Clonogenic, and Proliferative Potential of Adipose-Derived Stem Cell Populations Between Centrifuged and Noncentrifuged Fat

et al. 2014

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“…[1][2][3][4][6][7][8][9][10][11][12][13][14][15][16] Nine of the 15 studies were classified as level IV (case series), two as level III (a retrospective cohort and a comparative clinical study), one as level II (prospective cohort study), and three were not classified (for dealing with animal studies or review articles). No level I studies were found, that is, those with the strongest evidence (controlled and randomized clinical trials).…”

Section: Resultsmentioning

confidence: 99%

“…Generally speaking, the procedure presented a low rate of surgical complications and satisfactory evolution in the postoperative period. 15 A study by Moltó Garcia et al showed a rate of 3.35% for early complications from fat grafting, such as pain at the application site, seroma and Relief of cicatricial neuropathic pain due to improved quality of infection of the surgical wound. In relation to late-onset complications, this study indicated the presence of cysts at the fat grafting site (16.2% of cases) and calcifications (10.8% of cases).…”

Section: Discussionmentioning

confidence: 99%

Evidences of autologous fat grafting for the treatment of keloids and hypertrophic scars

Silva

Neto

Horácio

et al. 2016

Rev. Assoc. Med. Bras.

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SUMMARY Introduction Since the 1980s, the use of autologous fat grafting has been growing in plastic surgery. Recently, this procedure has come to be used as a treatment for keloids and hypertrophic scars mainly due to the lack of satisfactory results with other techniques. So far, however, it lacks more consistent scientific evidence to recommend its use. The aim of this study was to review the current state of autologous fat grafting for the treatment of keloids and hypertrophic scars, their benefits and scientific evidences in the literature. Method A review in the Pubmed database was performed using the keywords “fat grafting and scar”, “fat grafting and keloid scar” and “fat grafting and hypertrophic scar.” Inclusion criteria were articles written in English and published in the last 10 years, resulting in 15 studies. Results These articles indicate that autologous fat grafting carried out at sites with pathological scars leads to a reduction of the fibrosis and pain, an increased range of movement in areas of scar contraction, an increase in their flexibility, resulting in a better quality of scars. Conclusion So far, evidences suggest that autologous fat grafting for the treatment of keloids and hypertrophic scars is associated with a better quality of scars, leading to esthetic and functional benefits. However, this review has limitations and these findings should be treated with reservations, since they mostly came from studies with low levels of evidence.

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“…Exploring all surgical options for the management of chronic pain relating to breast cancer is outside the scope of this review article; however, it is worth noting that Caviggioli et al have had success with autologous fat grafting in painful mastectomy scars [45]. A more recent study by Maione et al found similar improvement in pain scores with autologous fat grafting for women suffering from chronic pain after breast conservative surgery and radiotherapy, an increasingly popular method of surgical treatment for breast cancer [46].…”

Section: Advances In Interventional Procedures For Breast Cancer Relamentioning

confidence: 99%

A review of Recent Advances in the Management of Breast Cancer Related Pain

Zocca¹,

Valimahomed

et al. 2018

Breast Cancer Manag.

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• As death rates have declined from breast cancer, more women are living with chronic pain relating to tumor-related pain, treatment-related pain and debility.• Physical therapy is grossly underutilized in women with breast cancer.• Physical therapy can be beneficial for acute breast cancer related pain such as shoulder pathology relating to protective posturing post surgery. It can also be beneficial for lymphedema, radiation fibrosis, arthralgias from aromatase inhibitors and hyperalgesia.• Novel interventional options for breast cancer related pain include the Pecs Block and Modified Pecs block (Pecs II).• Additional targets include the serratus plane block and the intercosteobrachial nerve.• Autologous fat grafting is beneficial for chronic pain related to mastectomy and breast conservative therapy.• Future directions for research include neuromodulation, radiofrequency ablation and chemoablation. We also feel that tailored anatomic approaches to breast cancer related pain will be the future of management.The incidence of breast cancer has stabilized over the past 10 years, while death rates have declined. Thus, many women are living with long-term effects of breast cancer, including pain syndromes relating to breast cancer. As our understanding of these types of pain syndromes improves, delivery of care to this population becomes paramount. In this review, we discuss advances in rehabilitation and interventional pain management to improve pain and symptom management. Appropriate use of physical therapy may significantly improve a patient's functional status, while fascial plane blocks can lead to pain relief which may last for months. Targeted therapies for pain relief may result in better quality of life for individuals suffering from breast cancer related pain. Breast cancer-related pain can be divided into three distinct categories: tumor-related pain, treatment-related pain and debility or pain unrelated to cancer, and can occur as acute, subacute or chronic pain. Tumor-related pain usually occurs during active treatment and in advanced disease stages. Treatment-related pain can present acutely and become chronic during treatments consisting of chemotherapy, radiation or hormonal therapy [3]. Subacute breast cancer-related pain is most often associated with arm and shoulder pain following breast cancer surgery [4].

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Autologous Fat Graft in Postmastectomy Pain Syndrome

Abstract: Therapeutic, II.

Cited by 151 publications

References 20 publications

Comparison of Cell Number, Viability, Phenotypic Profile, Clonogenic, and Proliferative Potential of Adipose-Derived Stem Cell Populations Between Centrifuged and Noncentrifuged Fat

Comparison of Cell Number, Viability, Phenotypic Profile, Clonogenic, and Proliferative Potential of Adipose-Derived Stem Cell Populations Between Centrifuged and Noncentrifuged Fat

Evidences of autologous fat grafting for the treatment of keloids and hypertrophic scars

A review of Recent Advances in the Management of Breast Cancer Related Pain

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