Autologous Fat Transfer for Breast Augmentation: A Review

Sufyani, Mohammed A. Al; AlHargan, Abdullah H; Shammari, Nayf A. Al; Sufyani, Mohannad A. Al

doi:10.1097/dss.0000000000000791

Cited by 45 publications

(26 citation statements)

References 57 publications

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“…With the overall survival rates increasing, more and more patients select breast reconstruction as a way to reduce the disabling effects of the mutilation . Autologous fat graft has been used as a filler for breast reconstruction in breast cancer patients following conservative surgery . That is partly because the ADSCs in adipose tissues (about 10 5 ADSCs per gram adipose tissue) can secrete numerous cytokines to benefit the proliferation and angiogenesis of the graft which make it a better graft than other materials .…”

Section: Introductionmentioning

confidence: 99%

Human Adipose-Derived Mesenchymal Stem Cell-Secreted CXCL1 and CXCL8 Facilitate Breast Tumor Growth By Promoting Angiogenesis

Wang¹,

Liu²,

Jiang

et al. 2017

Stem Cells

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Autologous adipose tissue or adipose tissue with additive adipose-derived mesenchymal stem cells (ADSCs) is used in the breast reconstruction of breast cancer patients who undergo mastectomy. ADSCs play an important role in the angiogenesis and adipogenesis, which make it much better than other materials. However, ADSCs may promote residual tumor cells to proliferate or metastasize, and the mechanism is still not fully understood. In this study, we demonstrated that human ADSCs (hADSCs) could facilitate tumor cells growth after co-injection with MCF7 and ZR-75-30 breast cancer cells (BCCs) by promoting angiogenesis, but hADSCs showed limited effect on the growth of MDA-MB-231 BCCs. Intriguingly, compared with ZR-75-30 tumor cells, MCF7 tumor cells were more potentially promoted by hADSCs in the aspects of angiogenesis and proliferation. Consistent with this, cytokine and angiogenesis array analyses showed that after co-injection with hADSCs, the CXCL1 and CXCL8 concentration were significantly increased in MCF7 tumor, but only moderately increased in ZR-75-30 tumor and did not increase in MDA-MB-231 tumor. Furthermore, we found that CXCL1/8 were mainly derived from hADSCs and could increase the migration and tube formation of human umbilical vein endothelial cells (HUVECs) by signaling via their receptors CXCR1 and CXCR2. A CXCR1/2-specific antagonist (SCH527123) attenuated the angiogenesis and tumor growth in vivo. Our findings suggest that CXCL1/8 secreted by hADSCs could promote breast cancer angiogenesis and therefore provide better understanding of safety concerns regarding the clinical application of hADSCs and suggestion in further novel therapeutic options. Stem Cells 2017;35:2060-2070.

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Section: Introductionmentioning

confidence: 99%

Human Adipose-Derived Mesenchymal Stem Cell-Secreted CXCL1 and CXCL8 Facilitate Breast Tumor Growth By Promoting Angiogenesis

Wang¹,

Liu²,

Jiang

et al. 2017

Stem Cells

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“…Although initially reported in 1895 by Czerny, liposuction and the method of autologous fat grafting were not used to the breast for augmentation until 1987 (Bircoll, 1987, Bircoll and Novack, 1987). As more evidence is published on the oncologic safety of fat grafting to the breast, more plastic surgeons are now routinely using the method in breast reconstruction surgery (Al Sufyani et al, 2016, Gurunluoglu et al, 2013).…”

Section: Cutaneous Complications Associated With Lipofillingmentioning

confidence: 99%

“…Previously used as a nonsurgical breast enlargement system, the BRAVA is now particularly helpful in assisting lipofilling augmentation in women who have very small breasts and/or very tight skin envelopes. The device enables a larger volume to be injected on the day of surgery and improves graft survival compared with more traditional lipofilling methods (Al Sufyani et al, 2016). The BRAVA technique achieves this by allowing the space to which fat can be added to enlarge through its vacuum, and it promotes angiogenesis to the existing tissue, which makes graft take more reliable (Al Sufyani et al, 2016, Gurunluoglu et al, 2013).…”

Section: Cutaneous Complications Associated With Lipofillingmentioning

confidence: 99%

“…The device enables a larger volume to be injected on the day of surgery and improves graft survival compared with more traditional lipofilling methods (Al Sufyani et al, 2016). The BRAVA technique achieves this by allowing the space to which fat can be added to enlarge through its vacuum, and it promotes angiogenesis to the existing tissue, which makes graft take more reliable (Al Sufyani et al, 2016, Gurunluoglu et al, 2013). However, a limitation is that patients are required to wear the device for approximately 10 to 12 hours per day for 4 weeks, both before and after the procedure.…”

Section: Cutaneous Complications Associated With Lipofillingmentioning

confidence: 99%

See 1 more Smart Citation

Cutaneous complications associated with breast augmentation: A review

Chopra

Marucci

2019

International Journal of Women's Dermatology

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Breast augmentation is one of the most popular and safe cosmetic procedures performed by plastic surgeons worldwide. Although breast implants are available in a number of different materials, silicone-filled implants remain the most common type. However, prior to the development of breast implants, various materials were injected into the soft tissues of the breasts to increase breast volume, which caused cutaneous complications and disfigurement. This review details the history of breast augmentation, the current methods used in augmentation surgery, and associated cutaneous complications.

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“…Die Hormonbehandlung führte in der Lipofilling-Gruppe zu einer signifikant erhöhten Rezidivrate (1,4 %) verglichen zum Brustaufbau ohne Eigenfett (0,5 %) (p = 0,038). In einer Reihe von weiteren Studien konnte kein Zusammenhang zwischen Lipotransfer und erhöhter Mammakarzinomrezidivrate festgestellt werden, jedoch wird die Nachbeobachtung über einen langen Zeitraum gefordert [43].…”

Section: Experimentelle Studienunclassified

Entwicklung eines neuen Zellisolationsverfahrens zur Erforschung der Mammakarzinompathogenese und -angiogenese für experimentelle in vitro und in vivo Assays

Weigand

Tasbihi

Strissel

et al. 2017

Handchir Mikrochir plast Chir

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Breast cancer is the world's most common cancer among women. Autologous lipotransfer is increasingly used for breast reconstruction following surgical removal of the tumour. In cell-assisted lipotransfer, the transplant is enriched with stem cells from adipose tissue (ADSC). Despite positive clinical results, there are some concerns regarding oncological safety due to transplanted stem cells. To date there are only a few breast cancer studies using primary cells from the same patient to enable further investigation into the complexity of cell-cell interactions in breast cancer in an experimental setting. We performed literature research on the topic of autologous lipotransfer. 5 different cell types (epithelial, mesenchymal cells, ADSC, endothelial cells, endothelial progenitor cells) were isolated from mammary (carcinoma) tissue or blood and were subsequently characterised for gene and protein expression as well as functional properties. The arteriovenous (AV) loop model in the rat was evaluated as a possible in vivo model for breast cancer pathogenesis and angiogenesis in this study. The literature provided evidence for an in-vitro interaction between ADSC and cells of the mammary (carcinoma) tissue. In some clinical studies, certain subgroups of patients appeared to be exposed to an increased risk of tumour recurrence after lipotransfer, but in most studies no correlation between lipotransfer and tumour recurrence was found. Different cell populations, which differed significantly in terms of surface markers, gene expression and functional properties, were isolated from tissue of the same patient. Axial vascularised tissue was successfully generated in the AV loop model. In this study we were able to isolate different cell populations from the same patient, which reflect the heterogeneity of the tumour tissue. This enables a precise analysis of cell-cell interactions and their effects on tumour angiogenesis and pathogenesis in breast cancer. In combination with the AV loop model, this offers new possibilities to generate vascularised mammary carcinoma tissue as well as healthy mammary gland tissue in vivo as an optimal model for the clinical setting.

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Autologous Fat Transfer for Breast Augmentation: A Review

Cited by 45 publications

References 57 publications

Human Adipose-Derived Mesenchymal Stem Cell-Secreted CXCL1 and CXCL8 Facilitate Breast Tumor Growth By Promoting Angiogenesis

Human Adipose-Derived Mesenchymal Stem Cell-Secreted CXCL1 and CXCL8 Facilitate Breast Tumor Growth By Promoting Angiogenesis

Cutaneous complications associated with breast augmentation: A review

Entwicklung eines neuen Zellisolationsverfahrens zur Erforschung der Mammakarzinompathogenese und -angiogenese für experimentelle in vitro und in vivo Assays

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