Autologous fibrin tissue adhesive

Siedentop, Karl H.; Harris, David; Sanchez, Ben

doi:10.1288/00005537-198509000-00011

Cited by 92 publications

(28 citation statements)

References 4 publications

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“…These results set the varying concentrations of fibrinogen and thrombin on fibrin sealant characteristics. A significant body of evi-stage for further human investigation of the clinical effectiveness of fibrin sealant in mastectomy seroma dence suggests that sealant strength is related to fibrinogen concentration [31][32][33], while sealant clotting prevention. time is dependent on thrombin concentration [31,32].…”

Section: Discussionmentioning

confidence: 99%

Effect of Fibrinogen and Thrombin Concentrations on Mastectomy Seroma Prevention

Sanders

Goodman

Amiss

et al. 1996

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

Effect of Fibrinogen and Thrombin Concentrations on Mastectomy Seroma Prevention

Sanders

Goodman

Amiss

et al. 1996

Journal of Surgical Research

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“…Once the communication has been occluded, the fibrin glue is expected to dissolve or be gradually resorbed by fibrinolysis, which may result in subsequent fibrosis. 9 Zhang et al 13 reported 31 cases treated by this method, and almost 80% of the patients had sufficient improvement in symptoms to allow a return to regular work. These authors also found that there was no significant distinction between groups with or without initial aspiration of the cyst.…”

Section: Discussionmentioning

confidence: 99%

Adhesive arachnoiditis after percutaneous fibrin glue treatment of a sacral meningeal cyst

Hayashi¹,

Nagano²,

Hattori³

2014

SPI

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The authors present the case of a 64-year-old woman who was referred for severe sacral pain. She reported that her pain had been longstanding, and had greatly increased after percutaneous fibrin glue placement therapy for a sacral meningeal cyst 2 months earlier at a different hospital. An MRI scan obtained immediately after fibrin glue placement at that hospital suggested that fibrin glue had migrated superiorly into the subarachnoid space from the sacral cyst to the level of L-4. On admission to the authors' institution, physical examination demonstrated no abnormal findings except for perianal hypesthesia. An MRI study obtained at admission demonstrated a cystic lesion in the peridural space from the level of S-2 to S-4. Inhomogeneous intensity was identified in this region on T2-weighted images. Because the cauda equina and nerve roots appeared to be compressed by the lesion, total cyst excision was performed. The cyst cavity was filled with fluid that resembled CSF, plus gelatinous material. Histopathological examination revealed that the cyst wall was composed of hyaline connective tissue with some calcification. No nervous tissue or ganglion cells were found in the tissue. The gelatinous material was acellular, and appeared to be degenerated fibrin glue. Sacral pain persisted to some extent after surgery. The authors presumed that migrated fibrin glue caused the development of adhesive arachnoiditis. The risk of adhesive arachnoiditis should be considered when this therapy is planned. Communication between a cyst and the subarachnoid space should be confirmed to be sufficiently narrow to prevent the migration of injected fibrin glue.

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“…4,5,7,9,11,[14][15][16][17][18]21,22 The continuing evolution in the preparation and use of fibrin glue is emphasized in the literature.…”

Section: Discussionmentioning

confidence: 99%

Use of autologous fibrin glue in dermatologic surgery: application of skin graft and second intention healing

1998

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Objective:To evaluate the efficiency of biological sealant, an autologous fibrin glue, in dermatological surgery. Design: Randomized clinical trial. Setting: The Dermatology Service of Hospital das Clínicas, Universidade de Campinas (UNICAMP), referral center. Patients: 14 patients with malign epithelial cutaneoos tumors participated in the evaluation, each having two tumors, generally facial and symmetrical, in order to perform a comparative evaluation on the same individual. Procedures: The glue was prepared beforehand with a sample of autologous blood. Surgical extirpation of the tumor was followed by grafts or second intention healing. Outcomes: The efficiency of the sealant was then evaluated in relation to hemostasis, adhesion, surgical time and evolution of the granulation tissue, clinically and histologically. Results: Immediate hemostasis and graft adhesion, with a significant reduction of surgical time, and in the open wounds there was immediate hemostasis and a clinical increase in granulation tissue, but with no histological differences among the groups on the 7 th day. Conclusion: It is an adjuvant resource in skin cancer surgery.Uniterms: Fibrin glue. Wound healing. Skin cancer. Dermatologic surgery.

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Autologous fibrin tissue adhesive

Cited by 92 publications

References 4 publications

Effect of Fibrinogen and Thrombin Concentrations on Mastectomy Seroma Prevention

Effect of Fibrinogen and Thrombin Concentrations on Mastectomy Seroma Prevention

Adhesive arachnoiditis after percutaneous fibrin glue treatment of a sacral meningeal cyst

Use of autologous fibrin glue in dermatologic surgery: application of skin graft and second intention healing

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