Autologous GVHD?

Engraftment Syndrome after Autologous Stem Cell Transplantation: An Update Unifying the Definition and Management Approach

“…Although a number of studies suggest that ES can be reversed by corticosteroid therapy, controlled trials have not been performed to directly assess the benefit of corticosteroids 38 . Nevertheless, a number of studies in animal models and humans suggest that the immune system plays a role in the development of ES, despite the absence of HLA and minor histocompatibility antigen mismatch.…”

One or two umbilical cord blood cell units? Caveat emptor

“…6 (Graft-versus-graft may qualify with other jargon phrases such as engraftment syndrome 7 and autologous GvHD. 8 Time will tell). Whether the subservient UCB unit is really lost is controversial.…”

Late recurrence of autologous GvHD in a myeloma patient: a myth or diagnostic challenge?

“…However, it is still unclear whether conditioning was a predisposing factor or a confounder with effects that mimicked GvHD. 10 Our patient developed clinical and histopathologic findings consistent with recurrent GvHD over 6 years after HCT and 10 months after the reintroduction of a lenalidomide-containing regimen. The timing of onset after initiation of lenalidomide is particularly notable given the known immunomodulatory effects of this agent.…”

“…1,3,9 The clinical, laboratory and histologic criteria used to diagnose acute GvHD lack specificity and this leads to diagnostic challenges. 10 For instance, infections, drug or radiation exposures can cause skin and GI epithelial changes that can mimic GvHD clinically and histologically at similar times after HCT. 10 In contrast to allogeneic GvHD, where the severity ranges from mild to severe, spontaneous autologous GvHD tends to be generally mild and steroid responsive.…”

“…10 For instance, infections, drug or radiation exposures can cause skin and GI epithelial changes that can mimic GvHD clinically and histologically at similar times after HCT. 10 In contrast to allogeneic GvHD, where the severity ranges from mild to severe, spontaneous autologous GvHD tends to be generally mild and steroid responsive. 9 However, Drobyski et al 11 reported five cases of severe and steroid-refractory GvHD in patients receiving autologous HCT for MM.…”