Autologous hematopoietic stem cell transplantation following high-dose chemotherapy for non-rhabdomyosarcoma soft tissue sarcomas

Peinemann, Frank; Smith, L. A.; Kromp, Mandy; Bartel, C.; Kröger, Nicolaus; Kulig, Michael

doi:10.1002/14651858.cd008216.pub3

Cited by 11 publications

(9 citation statements)

References 330 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the first version of this systematic review, we assumed a long follow-up and frequent events regarding death by disease or complication: NRSTS in figure 3 . 23 Thus, an RCT would be the best choice for all outcomes but we did not find any RCT and we did not find any comparative study. Instead, we identified only single-arm studies.…”

Section: Resultsmentioning

confidence: 89%

Development of an algorithm to provide awareness in choosing study designs for inclusion in systematic reviews of healthcare interventions: a method study

Peinemann

Kleijnen

2015

BMJ Open

Self Cite

View full text Add to dashboard Cite

Objectives:To develop an algorithm that aims to provide guidance and awareness for choosing multiple study designs in systematic reviews of healthcare interventions.Design: Method study: (1) To summarise the literature base on the topic. (2) To apply the integration of various study types in systematic reviews. (3) To devise decision points and outline a pragmatic decision tree. (4) To check the plausibility of the algorithm by backtracking its pathways in four systematic reviews.Results: (1) The results of our systematic review of the published literature have already been published. (2) We recaptured the experience from our four previously conducted systematic reviews that required the integration of various study types. (3) We chose length of follow-up (long, short), frequency of events (rare, frequent) and types of outcome as decision points (death, disease, discomfort, disability, dissatisfaction) and aligned the study design labels according to the Cochrane Handbook. We also considered practical or ethical concerns, and the problem of unavailable high-quality evidence. While applying the algorithm, disease-specific circumstances and aims of interventions should be considered. (4) We confirmed the plausibility of the pathways of the algorithm. Conclusions:We propose that the algorithm can assist to bring seminal features of a systematic review with multiple study designs to the attention of anyone who is planning to conduct a systematic review. It aims to increase awareness and we think that it may reduce the time burden on review authors and may contribute to the production of a higher quality review.

show abstract

Section: Resultsmentioning

confidence: 89%

Development of an algorithm to provide awareness in choosing study designs for inclusion in systematic reviews of healthcare interventions: a method study

Peinemann

Kleijnen

2015

BMJ Open

Self Cite

View full text Add to dashboard Cite

show abstract

“…This article is based on a Cochrane systematic review published in The Cochrane Library 10. Publication of this work is in agreement with the policy of The Cochrane Collaboration 11.…”

Section: Methodsmentioning

confidence: 90%

“…With respect to historical versions of the Cochrane Review,10 we applied two different search strategies and retrieved the same studies with aggregate data but different studies with individual cases data. These results show the substantial difficulty associated with the aim of searching for all published cases.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Autologous haematopoietic stem cell transplantation following high-dose chemotherapy for non-rhabdomyosarcoma soft tissue sarcomas: a Cochrane systematic review*

Peinemann

Labeit

2014

BMJ Open

View full text Add to dashboard Cite

ObjectivesWe conducted a systematic review to compare the efficacy and adverse events of autologous haematopoietic stem cell transplantation (HSCT) following high-dose chemotherapy (HDCT) versus standard-dose chemotherapy (SDCT) in patients with locally advanced or metastatic non-rhabdomyosarcoma soft tissue sarcomas (NRSTS). SettingPatients were observed in hospital units specialised for cancer therapy.ParticipantsThe review evaluated 294 patients with 19 different subtypes of malignant NRSTS. The patients had a median age between 10 and 46 years (range 2–65) and were mostly men.Primary and secondary outcome measureThe planned and measured primary outcomes were overall survival and treatment-related mortality. The planned and measured secondary outcomes were progression-free survival, grade 3–4 non-haematological toxicity and secondary neoplasia. Other secondary outcomes including disease-free survival, event-free survival and health-related quality of life were not reported.ResultsWe included 62 studies reporting on 294 transplanted patients. We identified 1 randomised controlled trial (RCT) with 38 transplanted and 45 non-transplanted patients and judged a low risk of bias. We further identified 61 single-arm studies with 256 transplanted patients. Overall survival in the RCT was reported not statistically significantly different between autologous HSCT following HDCT versus SDCT. The HR was 1.26 (95% CI 0.70 to 2.29; p=0.44) and the point estimates at 3 years were 32.7% vs 49.4%. Data from single-arm studies were used to extract data on adverse events. Treatment-related mortality was reported in 5.1% (15 of 294) transplanted patients.ConclusionsOverall survival in patients with locally advanced or metastatic NRSTS was not statistically different after autologous HSCT following HDCT compared with SDCT in a single RCT with a total of 83 patients. No other comparative study was available. The proportion of adverse events among the transplanted patients is not clear.

show abstract

“…The treatment is not standardized but generally includes local control with surgical resection and/or radiation along with multiagent chemotherapy . There are reports of hyperthermic intraperitoneal radiation and high‐dose chemotherapy followed by autologous stem cell transplant but neither therapy has demonstrated a definitive survival benefit . We present a case of a successfully treated isolated paratesticular DSRCT and review the literature.…”

Section: Introductionmentioning

confidence: 99%

Paratesticular desmoplastic small round cell tumors: A case report and review of the literature

Sedig

Geiger

Mody

et al. 2017

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Desmoplastic small round cell tumor (DSCRT) is a rare malignancy most often seen in the abdomen or pelvis of young men. Unfortunately, this disease is usually metastatic at diagnosis and has dismal outcomes. We describe a case of isolated paratesticular DSCRT in a 14-year-old male successfully treated with surgical resection, chemotherapy, and adjuvant radiation, and we present a review of the relevant literature. It appears that isolated, paratesticular DSCRTs have a markedly better outcome than the classic abdominal or pelvic location. We hypothesize that this is due to earlier detection and the relative ease of surgical resection.

show abstract

Autologous hematopoietic stem cell transplantation following high-dose chemotherapy for non-rhabdomyosarcoma soft tissue sarcomas

Cited by 11 publications

References 330 publications

Development of an algorithm to provide awareness in choosing study designs for inclusion in systematic reviews of healthcare interventions: a method study

Development of an algorithm to provide awareness in choosing study designs for inclusion in systematic reviews of healthcare interventions: a method study

Autologous haematopoietic stem cell transplantation following high-dose chemotherapy for non-rhabdomyosarcoma soft tissue sarcomas: a Cochrane systematic review*

Paratesticular desmoplastic small round cell tumors: A case report and review of the literature

Contact Info

Product

Resources

About