Autologous menstrual blood-derived stromal cells transplantation for severe Asherman's syndrome

Abstract

Registered in the Chinese Clinical Trial Registry (ChiCTR-ONB-15007464).

Unraveling the Molecular Signature of Extracellular Vesicles From Endometrial-Derived Mesenchymal Stem Cells: Potential Modulatory Effects and Therapeutic Applications

“…Recent preclinical studies have also evaluated their therapeutic effects in murine models of pulmonary fibrosis (Zhao et al, 2018), and experimental colitis (Lv et al, 2014). In addition, a recent clinical trial using autologous menstrual blood-derived stromal cells have shown satisfactory results for the treatment of severe Asherman's syndrome (Tan et al, 2016).…”

Endometrial stem cells and human reproductive failure

“…Autologous menstrual blood-derived stromal cells transplantation has been proposed as potential option for treating severe AS patient: in a study involving seven AS patients, the Authors isolated autologous stromal cells from menstrual blood and then transplanted them into the uterus. The results showed a significant increase in endometrial thickness (up to 7 mm in 5 women) and this could improve embryo implantation efficiency (51). Endometrial Atrophy (EA) has the same effects and reproductive outcome as AS.…”

Cellular therapies for the endometrium: An update

“…Although in their infancy, pilot clinical trials with endometrial‐derived stromal cell sources have proven safety and potential efficacy. Tan et al delivered in vitro expanded autologous menSCs to a cohort of 7 women with severe AS. The study reports an increased endometrial thickness as measured by ultrasound, and three conceptions after one or more rounds of cell therapy.…”