2017
DOI: 10.1186/s13287-017-0678-z
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Autologous mesenchymal stem cells or meniscal cells: what is the best cell source for regenerative meniscus treatment in an early osteoarthritis situation?

Abstract: BackgroundTreatment of meniscus tears within the avascular region represents a significant challenge, particularly in a situation of early osteoarthritis. Cell-based tissue engineering approaches have shown promising results. However, studies have not found a consensus on the appropriate autologous cell source in a clinical situation, specifically in a challenging degenerative environment. The present study sought to evaluate the appropriate cell source for autologous meniscal repair in a demanding setting of … Show more

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Cited by 55 publications
(50 citation statements)
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“…An increasing number of studies are supporting the idea that cell-based strategies effectively improve meniscus repair and regeneration 32 33. However, it is still not clear which cell type is most effective for meniscus repair 34 35. Recently, meniscus stem/progenitor cells have been considered as the most suitable cell type for meniscus injury repair due to them having the same tissue origin and histocompatibility,36 37 however, the characteristics, marker genes and isolation methods of human meniscus progenitor cells have not yet been fully elucidated.…”
Section: Discussionmentioning
confidence: 99%
“…An increasing number of studies are supporting the idea that cell-based strategies effectively improve meniscus repair and regeneration 32 33. However, it is still not clear which cell type is most effective for meniscus repair 34 35. Recently, meniscus stem/progenitor cells have been considered as the most suitable cell type for meniscus injury repair due to them having the same tissue origin and histocompatibility,36 37 however, the characteristics, marker genes and isolation methods of human meniscus progenitor cells have not yet been fully elucidated.…”
Section: Discussionmentioning
confidence: 99%
“…Long-term data of the prevention of osteoarthritis by meniscus reconstruction are also missing for animal models. However the resection of meniscal tissue leads to cartilage lesions and degenerative changes of the knee after a very short time (Zellner et al, 2017 ).…”
Section: Reviewmentioning
confidence: 99%
“…Several scaffolds have been developed ranging from synthetic polymers to more natural tissue-derived sources. In vitro studies have demonstrated the outcomes of using different cell types [7] and the benefits of adding growth factors to cultures that can promote GAG production and improve cell differentiation enhancing the bioactivity of the overall scaffold for integration [95]. Such study models have also shed light on the effects of inhibitory effects on the meniscal repair by interleukin-1 and tumor necrosis factor-α commonly upregulated in injured joints [96][97][98].…”
Section: Tissue Engineeringmentioning
confidence: 99%
“…Owing to the complex phenotype of meniscal tissue, tissue regeneration using stem cell therapy may hold the key to tackling meniscal tears. The use of both meniscal cells and mesenchymal stem cells (MSCs) have proven effective in regenerating meniscal tissue, however meniscal cell harvest poses an unacceptable donor site morbidity and tear site cells have little to no chondrogenic potential [7]. Therefore, the majority of research has been focused on stem cells where there is a reasonable amount of pre-clinical data but limited clinical data.…”
Section: Introductionmentioning
confidence: 99%