Autologous nerve graft repair of different degrees of sciatic nerve defect: stress and displacement at the anastomosis in a three-dimensional fnite element simulation model

Piao, Chengdong; Yang, Kun; Luo, Min

doi:10.4103/1673-5374.156986

Cited by 10 publications

(4 citation statements)

References 20 publications

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“…Tensile loading of injured peripheral nerve influences tissue repair [49] and should be considered in guidance channel design. Native peripheral nerve tissue is highly viscoelastic, capable of sustaining large deformations (~8% elongation) without damage to tissue, changes in conduction, or blood flow [50].…”

Section: Discussionmentioning

confidence: 99%

Thermally drawn fibers as nerve guidance scaffolds

et al. 2016

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Synthetic neural scaffolds hold promise to eventually replace nerve autografts for tissue repair following peripheral nerve injury. Despite substantial evidence for the influence of scaffold geometry and dimensions on the rate of axonal growth, systematic evaluation of these parameters remains a challenge due to limitations in materials processing. We have employed fiber drawing to engineer a wide spectrum of polymer-based neural scaffolds with varied geometries and core sizes. Using isolated whole dorsal root ganglia as an in vitro model system we have identified key features enhancing nerve growth within these fiber scaffolds. Our approach enabled straightforward integration of microscopic topography at the scale of nerve fascicles within the scaffold cores, which led to accelerated Schwann cell migration, as well as neurite growth and alignment. Our findings indicate that fiber drawing provides a scalable and versatile strategy for producing nerve guidance channels capable of controlling direction and accelerating the rate of axonal growth.

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Section: Discussionmentioning

confidence: 99%

Thermally drawn fibers as nerve guidance scaffolds

et al. 2016

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“…Computer simulation could be used to better understand the mechanical and biology change in vivo by the prediction of the three-dimensional finite element method recently ( 27 ). To analyze the mechanical effect of the daily baby lifting motion on the Chinese elderly women, a lumbar finite element model with the unique geometry of Chinese elderly women was developed in this study.…”

Section: Discussionmentioning

confidence: 99%

The Multi-Modal Risk Analysis and Medical Prevention of Lumbar Degeneration, Fatigue, and Injury Based on FEM/BMD for Elderly Chinese Women Who Act as Stay-Home Grandchildren Sitters

Cavagnaro

Xiong

et al. 2021

Front. Public Health

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Background: An increasing number of Chinese elderly women stay at home and act as grandchildren sitters. In consequence of the frequent load-bearing, chronic lumbar fatigue probably caused a higher risk of lumbar degeneration, fatigue, and injury which has become one of the most important aging and health problems in China. In this study, a multi-mode lumbar finite element model (FEM) with specific bone mineral density (BMD) were developed and validated for further spine injury prevention and control.Methods: The material properties of lumbar vertebra were modified according to degenerated bone mineral density, and geometry was adjusted based on intervertebral disc height. The motion of lifting children was simulated by a 76 year-old Chinese women's FEM, and the stress distribution was calculated and predicted.Results: The pressure of L5-S intervertebral disc in the bending 3-year-old dummy lifting posture was significantly higher than the same posture without lifting, the maximum effective stress of endplate cartilage in the upright child lifting posture was 1.6 times that of the bending without lifting posture. And the fatigue risk limitation frequency of the upright with dummy posture was predicted with the functional equation of fatigue and stress which was deduced by genetic algorithm, which combined with the effective stress of lumbar vertebrae spongy bone calculated from FEM.Conclusions: The child-lifting motion could increase the risk of lumbar degeneration, fatigue, and injury in elderly women, and they should keep below the frequency limit of the motion of lifting children in their daily life. This study could put forward scientific injury prevention guidance to Chinese elderly women who lift children in daily life frequently.

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“…This analysis is obtained by dividing the problem domain in several elements with simple geometry to which known physical laws are applied (Liu & Quek, 2003). This numerical method can be used to create three-dimensional models of the peripheral nerve and the chitosan NGC to calculate tension values and deformations at specific points after applying loads (Behforootan, Chatzistergos, Naemi, & Chockalingam, 2016;Piao, Yang, Li, & Luo, 2015). Considering peripheral nerves, tissue mechanics and FEM analysis can be combined to explore their response when subjected to different stimuli (Giannessi, Stornelli, & Sergi, 2017).…”

Section: Numerical Analysismentioning

confidence: 99%

3rd Symposium on Occupational Safety and Health Proceedings Book

2019

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Introduction: Osteopathy is an emergent health-care profession, present in most of the developed world and since 2013, regulated in Portugal. Osteopaths intervene in a range of health issues in which pain is a very common aspect. Pain is a worldwide problem, affecting all aspects of society. Measurement of pain objectively is yet not possible; even considered unreliable in many circumstances, the standard is selfreported questionnaires. A variety of different scales were used to measure the intensity of pain in Osteopathic research; however, the criteria of the options are not always clear or reported. This review aims to analyze and critically compare the different characteristics of the most used questionnaires by osteopathic researchers for assessing the intensity of pain in randomized controlled trials (RCT). Methodology: A literature search was conducted using 7 electronic databases. This search was conducted for RCT articles studying the efficacy/effectiveness of the osteopathic manipulative treatment (OMT) intervention in pain. The findings followed the PRISMA statement. Included studies were assessed for the risk of bias (RoB) using the Jadad score. Results and Discussion: 123 studies were identified, and after removal of duplicates and application of the eligibility criteria, 21 articles were included for this review. Nine studies used the Visual Analogue Scale (VAS) 10cm scale, seven the Numeric Rating Scale (NRS) 11 points scale, the remaining used other options. Although similar, there are differences in these two scales that may affect the outcomes. Justification of the choice of the evaluation instrument was not always present and not associated with the methodology and the target population. The overall quality of the studies, in terms of RoB, was considered good. Conclusion: VAS and NRS are the choices of most authors. Authors in Osteopathy, or other health care professions should be very clear about the reasons behind the choices for measuring the intensity of pain; these should fit the objectives and study design.

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Autologous nerve graft repair of different degrees of sciatic nerve defect: stress and displacement at the anastomosis in a three-dimensional fnite element simulation model

Cited by 10 publications

References 20 publications

Thermally drawn fibers as nerve guidance scaffolds

Thermally drawn fibers as nerve guidance scaffolds

The Multi-Modal Risk Analysis and Medical Prevention of Lumbar Degeneration, Fatigue, and Injury Based on FEM/BMD for Elderly Chinese Women Who Act as Stay-Home Grandchildren Sitters

3rd Symposium on Occupational Safety and Health Proceedings Book

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