Autologous osteochondral grafting—Technique and long-term results

Hangody, László; Vásárhelyi, Gábor; Sükösd, Zita; Tibay, György; Bartha, Lajos; Bodó, Gábor

doi:10.1016/j.injury.2008.01.041

Cited by 411 publications

(338 citation statements)

References 41 publications

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“…Hangody et al published the largest series of OATS in the talus. 178 The authors reported that 93% of 98 patients had good to excellent clinical results on the basis of evaluation with the Hannover score, but the duration of follow-up was not reported. The main disadvantage of OATS is the donor-site morbidity, which has been reported to occur in up to 50% of cases.…”

Section: Part III -Secondary Surgical Treatment With a Metal Resurfacmentioning

confidence: 99%

Treatment of osteochondral defects of the talus

Bergen

Leeuw

Dijk

2008

Revue de Chirurgie Orthopédique et Réparatrice de l'Appareil Mo

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Section: Part III -Secondary Surgical Treatment With a Metal Resurfacmentioning

confidence: 99%

Treatment of osteochondral defects of the talus

Bergen

Leeuw

Dijk

2008

Revue de Chirurgie Orthopédique et Réparatrice de l'Appareil Mo

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“…For one, morbidity at the donor site limits the size of defects that can be repaired to an optimal maximum size of 1-4 cm 2 . 4 Post-operative symptoms related to the donor site such as persistent pain have been reported by several authors. 5−7 Donor site bleeding has been implicated as a cause of early hemarthrosis.…”

mentioning

confidence: 96%

“…5−7 Donor site bleeding has been implicated as a cause of early hemarthrosis. 4,8 In addition, the surgical difficulty of shaping host tissue to fit the defect area is a limiting factor. 9 Inadequate bonding of the graft cartilage to surrounding tissue is a common finding noted in second-look arthroscopy in clinical subjects 10 as well as histological analysis in animal models.…”

mentioning

confidence: 99%

A novel MSC‐seeded triphasic construct for the repair of osteochondral defects

Marquaß

Somerson

Hepp

et al. 2010

Journal Orthopaedic Research

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Mesenchymal stem cells (MSC) are increasingly replacing chondrocytes in tissue engineering based research for treatment of osteochondral defects. The aim of this work was to determine whether repair of critical-size chronic osteochondral defects in an ovine model using MSC-seeded triphasic constructs would show results comparable to osteochondral autografting (OATS). Triphasic implants were engineered using a beta-tricalcium phosphate osseous phase, an intermediate activated plasma phase, and a collagen I hydrogel chondral phase. Autologous MSCs were used to seed the implants, with chondrogenic predifferentiation of the cells used in the cartilage phase. Osteochondral defects of 4.0 mm diameter were created bilaterally in ovine knees (n = 10). Six weeks later, half of the lesions were treated with OATS and half with triphasic constructs. The knees were dissected at 6 or 12 months. With the chosen study design we were not able to demonstrate significant differences between the histological scores of both groups. Subcategory analysis of O'Driscoll scores showed superior cartilage bonding in the 6-month triphasic group compared to the autograft group. The 12-month autograft group showed superior cartilage matrix morphology compared to the 12-month triphasic group. Macroscopic and biomechanical analysis showed no significant differences at 12 months. Autologous MSC-seeded triphasic implants showed comparable repair quality to osteochondral autografts in terms of histology and biomechanical testing.

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“…This technique achieved good clinical and radiological results according to the Epstein criteria at 2 years and prevented early joint degeneration [22]. Although osteochondral transplantation is a well-described technique for the treatment of osteochondral defects in joints [23][24][25][26], the treatment of osteochondral defects in the hip joint has not been extensively described in the literature. Based on our results in this particular case, we recommend this technique as a salvage procedure for femoral head impaction fractures also after posterior hip dislocation and we confirm nonoperative treatment recommendations in cases of superficial femoral head impaction defects.…”

Section: Discussionmentioning

confidence: 99%