Autologous Peripheral Blood Stem Cells Increase the Telomere Length in Patient: A Case Report of 13 Patients

Gargiulo, Ciro; Pham, Van Hung

doi:10.4172/2157-7633.1000352

Cited by 7 publications

(16 citation statements)

References 33 publications

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“…Nestin in charge of pluripotency and multipotency. Of note, these are the same genes tha were characterized by our team on circulatory stem cells collected from human periphera blood [13][14][15].…”

Section: Hypothesis: Why Stem Cells Could Be a Possible Solutionmentioning

confidence: 86%

“…Their assumption to obtain pluripotent stem cells from normal adult cells was eventually confirmed by molecular engineering through the insertion into the cells of genes such as Oct4, Sox2, Nanog, Osteocalcin (OCN), Nestin in charge of pluripotency and multipotency. Of note, these are the same genes that were characterized by our team on circulatory stem cells collected from human peripheral blood [13][14][15].…”

Section: Hypothesis: Why Stem Cells Could Be a Possible Solutionmentioning

confidence: 95%

“…Telomeres are specialized DNA-protein arrangements that firmly sealed the ends of linear chromosomes. The telomeres need constant extension of telomeric DNA repeats to preserve chromosomes stability and conserved [15]. Therefore, anything that may negatively affect telomeres may eventually drive to chromosome dramatic changes driving to harsh systemic consequences [12].…”

Section: Hypothesis: Why Stem Cells Could Be a Possible Solutionmentioning

confidence: 99%

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Mesenchymal Stem Cells: The Secret Children’s Weapons against the SARS-CoV-2 Lethal Infection

et al. 2021

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Due to the promising effects of mesenchymal stem cells (MSCs) in the treatment of various diseases, this commentary aimed to focus on the auxiliary role of MSCs to reduce inflammatory processes of acute respiratory infections caused by the 2019 novel coronavirus (COVID-19). Since early in 2020, COVID-19, a consequence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly affected millions of people world-wide. The SARS-CoV-2 infection in children appears to be an unusual event. Despite the high number of affected adult and elderly, children and adolescents remained low in amounts, and marginally touched. Based on the promising role of cell therapy and regenerative medicine approaches in the treatment of several life-threatening diseases, it seems that applying MSCs cell-based approaches can also be a hopeful strategy for improving subjects with severe acute respiratory infections caused by COVID-19.

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Section: Hypothesis: Why Stem Cells Could Be a Possible Solutionmentioning

confidence: 86%

Section: Hypothesis: Why Stem Cells Could Be a Possible Solutionmentioning

confidence: 95%

Section: Hypothesis: Why Stem Cells Could Be a Possible Solutionmentioning

confidence: 99%

See 1 more Smart Citation

Mesenchymal Stem Cells: The Secret Children’s Weapons against the SARS-CoV-2 Lethal Infection

et al. 2021

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“…This ability is due to the unique biological features of MSCs being capable of regulating the immune system via the stimulation of immune-modulatory cells such as gamma/delta T lymphocytes (γ/δ T Cells), macrophages type 2 (M2), and Th2 T-cells. In addition, MSCs differentiate into mature cells for the formation of new tissues such as the type II alveolar epithelial (ATII) cells that form approximately 60% of the pulmonary alveolar epithelium [175,[180][181][182]. By inhibiting the production of pro-inflammatory cytokines and interleukins, such as TNF-a, IFN-y, IL-6, IL-2, and IL-1 via the inhibitory mechanism exerted on monocytes differentiation towards T-lymphocytes, B-lymphocytes, NK cells, and dendritic cells (DCs), the MSCs are shown to mitigate self-destructive auto-immune mechanisms [139,[183][184][185][186][187][188].…”

Section: Stem Cells Autologous and Allograftmentioning

confidence: 99%

“…The MSCs' ability to limit self-attacking responses is consistent with their low level of co-stimulatory factors CD-80 and CD-86 (MHC I), which are essential for the MHC class II activation and for the triggering of T cells' second immune response; this is similar to what happens during a severe graft-versus-host disease (GVHD) and during the last phase of COVID-19 infection. In vivo, MSCs have shown they can treat steroidresistant GVHD in patients who underwent either allogeneic organ or hematopoietic stem cells transplantation, thus improving the general outcomes of the consequences of aberrant auto-destructive immune responses [175,184,[189][190][191][192]. Of note, the MSCs' long telomeres allow them a continuing replicative process, and therefore a constant immune modulation during inflammation and infections.…”

Section: Stem Cells Autologous and Allograftmentioning

confidence: 99%

The 15-Months Clinical Experience of SARS-CoV-2: A Literature Review of Therapies and Adjuvants

et al. 2021

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Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for the coronavirus disease of 2019 (COVID-19) that emerged in December 2019 in Wuhan, China, and rapidly spread worldwide, with a daily increase in confirmed cases and infection-related deaths. The World Health Organization declared a pandemic on the 11th of March 2020. COVID-19 presents flu-like symptoms that become severe in high-risk medically compromised subjects. The aim of this study was to perform an updated overview of the treatments and adjuvant protocols for COVID-19. Methods: A systematic literature search of databases was performed (MEDLINE PubMed, Google Scholar, UpToDate, Embase, and Web of Science) using the keywords: “COVID-19”, “2019-nCoV”, “coronavirus” and “SARS-CoV-2” (date range: 1 January 2019 to 31st October 2020), focused on clinical features and treatments. Results: The main treatments retrieved were antivirals, antimalarials, convalescent plasma, immunomodulators, corticosteroids, anticoagulants, and mesenchymal stem cells. Most of the described treatments may provide benefits to COVID-19 subjects, but no one protocol has definitively proven its efficacy. Conclusions: While many efforts are being spent worldwide in research aimed at identifying early diagnostic methods and evidence-based effective treatments, mass vaccination is thought to be the best option against this disease in the near future.

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Mesenchymal Stem Cells Could Be Considered as a Candidate for Further Studies in Cell-Based Therapy of Alzheimer’s Disease via Targeting the Signaling Pathways

Farahzadi

Fathi

Vietor

2020

ACS Chem. Neurosci.

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Mesenchymal stem cells (MSCs) are of particular interest because of their potential in regenerative medicine. Stem cell-based therapies cast a new hope for neurodegenerative disease treatment as a regeneration strategy, including treatment for Alzheimer's disease (AD). A multitude of cytokines and factors secreted from MSCs are known to give such multifunctional properties, but associated mechanisms of these factors have yet to be entirely understood. To better understand the in vitro effect of MSCs on a neurodegenerative disorder, we treated primary cortical and hippocampal neural cells with amyloid β (Aβ) as an in vitro cell line model for AD. For this purpose, bone marrow-derived MSCs (BMSCs) were cocultured with Aβ-treated neural cells, collected at day 3, and subjected to absolute telomere length measurement and telomerase activity assay. Next, the gene and protein expression levels of mTOR, p-mTOR, AMPK, p-AMPK, GSK-3β, p-GSK-3β, Wnt3, and β-catenin were investigated. Also, after 3 days of coculture treatment, the supernatant was collected from both groups for cytokine measurement. It was found that telomere length as a biomarker in neurodegenerative disorder as well as telomerase activity had significantly increased in the experimental group, and the presence of IL-6, IL-10, and TGF-β was obviously significant in the cocultured media. Also, BMSCs significantly changed the gene and protein expression of mTOR, AMPK, GSK-3β, and Wnt3/βcatenin signaling pathways components. It was concluded that the mentioned effects of MSCs on neural cells as an in vitro cell line model for AD as a therapeutic agent can be related to the signaling network.

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Autologous Peripheral Blood Stem Cells Increase the Telomere Length in Patient: A Case Report of 13 Patients

Cited by 7 publications

References 33 publications

Mesenchymal Stem Cells: The Secret Children’s Weapons against the SARS-CoV-2 Lethal Infection

Mesenchymal Stem Cells: The Secret Children’s Weapons against the SARS-CoV-2 Lethal Infection

The 15-Months Clinical Experience of SARS-CoV-2: A Literature Review of Therapies and Adjuvants

Mesenchymal Stem Cells Could Be Considered as a Candidate for Further Studies in Cell-Based Therapy of Alzheimer’s Disease via Targeting the Signaling Pathways

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