Autologous platelet concentrates for bisphosphonate-related osteonecrosis of the jaw treatment and prevention. A systematic review of the literature

Fabbro, Massimo Del; Gallesio, Giorgia; Mozzati, Marco

doi:10.1016/j.ejca.2014.10.015

Cited by 94 publications

(86 citation statements)

References 84 publications

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“…Del Fabbro et al, in their systematic review, illustrated the data about fourteen studies published between 2007 and 2014; the BRONJ surgical treatment with an adjunct autologous platelet concentrates showed a satisfactory healing in 91,6% of the cases [36]. All these data are in agreement with our results in the treatment of BRONJ stage IIB.…”

Section: Discussionsupporting

confidence: 86%

Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Study

Mauceri

Panzarella

Maniscalco

et al. 2018

BioMed Research International

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Introduction The management of bisphosphonate-related osteonecrosis of the jaw (BRONJ), with no evidence-based guidelines, remains controversial. We aimed to evaluate the efficiency of a conservative surgical treatment combining Er,Cr:YSGG laser and platelet-rich plasma (PRP) for the treatment of BRONJ in cancer patients. Methods We performed a longitudinal cohort study. Inclusion criteria were (1) age ≥ 18 years; (2) cancer diagnosis; (3) treatment with NBP because of the underlying cancer. Results We consecutively recruited ten patients diagnosed with BRONJ in stage I or II. These patients underwent a surgical laser-assisted therapy together with autologous PRP. At the latest follow-up at 12 months, clinical improvement was observed in eight patients. Registration Number is IRCT20180329039159N1. Conclusion We could successfully manage the BRONJ utilizing this combined protocol to heal the 30% of surgically treated sites and to improve the 50% of patients' lesions clinically. Our findings suggest that a surgical approach combined with Er,Cr:YSGG laser and PRP benefit cancer patients with general health issues.

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Section: Discussionsupporting

confidence: 86%

Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Study

Mauceri

Panzarella

Maniscalco

et al. 2018

BioMed Research International

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“…Favorable results were obtained when associating surgery therapy with PRP to promote wound healing compared with a surgical approach without PRP (complete response of 93% in the PRP group vs 53% in the control group) . Furthermore, PRP is autologous, biocompatible, and a safe product . Its use seems to be particularly useful in MRONJ surgical therapy, as the lack of vascularization represents one of the main factors in its pathogenesis …”

Section: Discussionsupporting

confidence: 70%

Adjuvant therapies in the management of medication‐related osteonecrosis of the jaws: Systematic review

et al. 2019

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Background We investigated the efficacy of hyperbaric oxygen (HBO), low‐intensity laser (LIL), and platelet‐rich plasma (PRP) in the management of medication‐related osteonecrosis of the jaws (MRONJ). Methods A literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement. Two examiners independently assessed eligibility and risk of bias and extracted data. Results There was improvement in 75.6% of the 41 patients submitted to HBO, with positive effects on pain relief and decreased size and number of lesions at a faster rate, with better effects when the drug was discontinued. For LIL, 158 (64.2%) of the 246 patients/sites improved the symptoms and 98 (39.8%) healed completely. Fourteen (17.3%) of the 81 patients treated with PRP significantly improved the symptoms and 65 (80.2%) completely healed. Conclusions These therapies served as safe and effective adjuvant modalities for MRONJ treatment. The lack of randomized clinical trials evidences the need for more high‐quality investigations on the subject.

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“…Dell Fabbro et al (25), in a systematic review, suggested that the use of platelet concentrations as an adjunct to the oral surgery procedure may have a beneficial effect for the post-surgical prevention, occurrence or recurrence of MRONJ in patients under treatment with bisphosphonates.…”

Section: Discussionmentioning

confidence: 99%

Surgery Combined with LPRF in Denosumab Osteonecrosis of the Jaw: Case Report

et al. 2016

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This paper describes two cases in which the use of leucocyte-rich and platelet-rich fibrin (LPRF) combined with bone resection did not result in complete tissue response in the treatment of medication-related osteonecrosis of the jaw (MRONJ). It has been recently described in patients receiving subcutaneous administration of RANK-inhibitors, such as Denosumab, and anti-angiogenic drugs, such as Bevacizumab, as observed in our cases. Due to promising results in recent studies, more patients will receive these medications in order to avoid skeletal complications due to metastatic bone disease and, therefore, this scenario has a potential to become a comparable challenge to the bisphosphonateinduced jaw necrosis in the area of Oral and Maxillofacial Surgery. No convincing surgical technique has been described to overcome the non-healing mucosal lesions with exposed bone due to RANK-inhibitor therapy. Based on the findings in the literature and in both cases described herein can be concluded that the use of LPRF should be considered in the treatment of patients with DRONJ. S u r g e r y C o m b i n e d w i t h L P R F i n D e n o s u m a b O s t e o n e c r o s i s o f t h e J a w : C a s e R e p o r t

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Autologous platelet concentrates for bisphosphonate-related osteonecrosis of the jaw treatment and prevention. A systematic review of the literature

Cited by 94 publications

References 84 publications

Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Study

Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Study

Adjuvant therapies in the management of medication‐related osteonecrosis of the jaws: Systematic review

Surgery Combined with LPRF in Denosumab Osteonecrosis of the Jaw: Case Report

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