Autologous platelet rich plasma for arthroscopic rotator cuff repair. A pilot study

Randelli, Pietro; Arrigoni, Paolo; Cabitza, Paolo; Volpi, Piero; Maffulli, Nicola

doi:10.1080/09638280801906081

Cited by 190 publications

(159 citation statements)

References 22 publications

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“…The results, although irregular, don't improve the ones obtained when autograft is used [1,15,22]. The clinical experience is even more contradictory.…”

Section: Discussionmentioning

confidence: 90%

Evaluation of autologous platelet concentrate for intertransverse lumbar fusion

et al. 2011

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Introduction The aim of the study was to analyze if the adding of autologous platelet concentrate (APC) to a mixture of local autograft plus tricalcium phosphate and hidroxiapatite (TCP/HA) would improve the fusion rate in posterolateral lumbar fusion. Materials and methods A prospective, controlled, blinded, non-randomized clinical trial was carried out in 107 patients affected by degenerative lumbar pathology. The study group consisted of 67 patients, in which autologous platelet concentration was added to a mixture of autologous local bone graft and TCP/HA. A control group of 40 patients with same pathology and surgical technique but without APC addition was used to compare the fusion mass obtained. By means of plain X-rays, a blinded evaluation of the intertransverse fusion mass quality at twelve and twenty-four months was made according to type A (bilateral uniform mass), type B (unilateral uniform mass) and type C (irregular or lack bilateral mass). Patients with type C were regarded as pseudoarthrosis. ResultsIn the study group 17 patients had lack or irregular fusion mass (25.4%) versus three patients in the control group (7.5%), which was statistically significant. ConclusionsThis study shows that the adding of autologous platelet concentration to a mixture of autologous bone graft plus TCP/HA has decreased our rates of posterolateral lumbar fusion.

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“…The results, although irregular, don't improve the ones obtained when autograft is used [1,15,22]. The clinical experience is even more contradictory.…”

Section: Discussionmentioning

confidence: 90%

Evaluation of autologous platelet concentrate for intertransverse lumbar fusion

et al. 2011

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“…For each growth factor, levels in the subacromial space were markedly higher than levels in the serum. These observations indicate growth factors may be equally important during the beginning of the healing process as toward the end [44].…”

Section: Biology Of Bone-to-tendon Healingmentioning

confidence: 81%

“…A total of 14 patients undergoing arthroscopic repair of a rotator cuff tear received an intraoperative application of autologous PRP in combination with an autologous thrombin component after tear repair. The authors concluded application of PRP during arthroscopic rotator cuff repair is safe and effective, without any adverse events [44]. Further prospective studies are needed to investigate the effect of PRP on rotator cuff healing and ultimate shoulder function.…”

Section: Growth Factor Additionmentioning

confidence: 89%

“…Platelet-derived growth factor b (PDGF-b), correlated to increased levels of Type I collagen, is also present in low levels throughout the repair [32,52]. Although the repair stage of healing classically begins at the end of the first week, Randelli et al [44] report some of these cytokines appear immediately after surgical repair procedures. Fifteen minutes after performing arthroscopic acromioplasty and other shoulder procedures on patients, 3 mL of liquid was removed from the subacromial space and from the venous blood supply.…”

Section: Biology Of Bone-to-tendon Healingmentioning

confidence: 99%

“…Because of this, there is a great amount of interest in the creation of ''platelet-rich plasma'' (PRP) by centrifuging autologous blood to purify a dense, suturable plasma matrix [44]. PRP includes many of the growth factors identified previously as crucial in normal bone-to-tendon healing: TGF-b, bFGF, PDGF, vascular endothelial growth factor, connective tissue growth factor, and epidermal growth factor [17].…”

Section: Growth Factor Additionmentioning

confidence: 99%

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Strategies in Biologic Augmentation of Rotator Cuff Repair: A Review

Cheung

Silverio

Sperling

2010

Clinical Orthopaedics &Amp; Related Research

147

103

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Background Degenerative rotator cuff tears are increasing with the aging population, and healing is not uniform after surgery. Rotator cuffs may show improved healing when biologic factors are added during surgery. Questions/purposes We asked: (1) What cellular processes are involved in normal bone-to-tendon healing? (2) What approaches are being developed in tendon augmentation? (3) What approaches are being developed with the addition of growth factors? Methods We reviewed research in relating to biologic augmentation and cellular processes involved in rotator cuff repair, focusing on animal models of rotator cuff repair and nonrandomized human trials. Results Regular bone-to-tendon healing forms a fibrous junction between tendon and bone that is distinct from the original bone-to-tendon junction. Tendon augmentation with cellular components serves as scaffolding for fibroblastic cells and a possible source of growth factors and fibroblastic cells. Extracellular matrices provide a scaffold for incoming fibroblastic cells, although current research does not conclusively confirm which if any of these scaffolds enhance repair owing in part to intermanufacturer variations and the limited human research. Growth factors and platelet-rich-plasma are established in other fields of research and may enhance repair but have not been rigorously tested. Conclusions There is potential application of biologic augmentation to improve healing after rotator cuff repair. However, research in this field is still inconclusive and has not been sufficiently demonstrated to merit regular clinical use. Future human trials can elucidate the use of biologic augmentation in rotator cuff repairs.

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Proliferation and differentiation of human tenocytes in response to platelet rich plasma: An in vitro and in vivo study

Wang

Qiu

Triffitt

et al. 2011

Journal Orthopaedic Research

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Platelet rich plasma (PRP) is the autologous plasma fraction with a platelet-rich cellular component which is enriched with a number of growth factors. Due to its availability and low cost, PRP has become an increasingly popular clinical tool as an alternative source of growth factors for various applications, for example, tendon regeneration but with limited success in clinical trials. The main objective of the current study was to determine whether activated PRP [i.e., platelet rich plasma-clot release (PRCR)] could be used to induce the proliferation and collagen synthesis in human tenocyte in vitro. The advantage of using PRCR is that the platelet-derived bioactive factors are more concentrated and could initiate a more rapid and accelerated healing response than PRP. Our results demonstrated that 10% PRCR treatment accelerated the extent of cell proliferation and collagen production by human tenocytes in vitro. The expression of specific tenocyte markers were similar to conventional fetal bovine serum (FBS)-treated tenocytes implanted in mice within 14 days of implantation in diffusion chambers. Moreover, relatively more collagen fibrils were evident in PRCR-treated tenocytes in vivo as compared to 10% FBS-treated cells. Overall, our feasibility study has indicated that PRCR can induce human tenocyte proliferation and collagen synthesis which could be implemented for future tendon regeneration in reconstructive surgeries. ß

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Autologous platelet rich plasma for arthroscopic rotator cuff repair. A pilot study

Cited by 190 publications

References 22 publications

Evaluation of autologous platelet concentrate for intertransverse lumbar fusion

Evaluation of autologous platelet concentrate for intertransverse lumbar fusion

Strategies in Biologic Augmentation of Rotator Cuff Repair: A Review

Proliferation and differentiation of human tenocytes in response to platelet rich plasma: An in vitro and in vivo study

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