Autologous platelet-rich plasma gel to reduce donor-site morbidity after patellar tendon graft harvesting for anterior cruciate ligament reconstruction: a randomized, controlled clinical study

Cervellin, M.; Girolamo, Laura de; Bait, Corrado; Denti, Matteo; Volpi, Piero

doi:10.1007/s00167-011-1570-5

Cited by 135 publications

(133 citation statements)

References 25 publications

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“…However, in an intraoperative setting, PRP may be injected as a liquid or gel 52 , or delivered as a fibrin matrix (platelet-rich fibrin matrix, PRFM) 53 . Most of the surgical applications of PRP for hip and pelvic pathology are novel, with few studies currently in the literature.…”

Section: Surgical Applicationsmentioning

confidence: 99%

The use of platelet-rich plasma to augment conservative and surgical treatment of hip and pelvic disorders

Kraeutler

Garabekyan

Mei-Dan³

2016

MLTJ

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Section: Surgical Applicationsmentioning

confidence: 99%

The use of platelet-rich plasma to augment conservative and surgical treatment of hip and pelvic disorders

Kraeutler

Garabekyan

Mei-Dan³

2016

MLTJ

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“…Gels, such as collagen type I [3,4] and platelet-rich plasma [5], have been investigated but their use is currently limited due to issues with purity and regulatory standards (such as the FDA and MHRA), and their inherent weak mechanical properties that are essential for this type of tissue. Electrospun fibre scaffolds are finding increasing use…”

Section: Introductionmentioning

confidence: 99%

Travelling along the Clinical Roadmap: Developing Electrospun Scaffolds for Tendon Repair

Bosworth

2014

Conference Papers in Science

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Biopolymers, such as poly( -caprolactone), can be easily electrospun to create fibrous scaffolds. It is also possible to control the alignment of the emitted fibres and further manipulate these scaffolds to create 3D yarn structures, which resemble part of the tendon tissue hierarchy. Material properties, such as tensile strength, can be tailored depending on the selection and combination of polymer and solvent used during electrospinning. The scaffolds have been proven to separately support the adhesion and proliferation of equine tendon fibroblasts and human mesenchymal stem cells whilst simultaneously directing cell orientation, which caused their alignment parallel to the underlying fibres. Implantation of scaffolds into the flexor digitorum profundus tendon of mice hindpaws yielded encouraging results with minimal inflammatory reaction and observation of cell infiltration into the scaffold. This research demonstrates the progression of electrospun fibres along the clinical roadmap towards becoming a future medical device for the treatment of tendon injuries.

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“…17,24 The use of PRP in the patellar tendon harvest site reduced donor site morbidity after ACL reconstruction. 9 However, other high-level evidence studies have not shown benefits in the use of PRP. A level I study found PRP to be as efficient as saline in Achilles tendinopathy treatment.…”

mentioning

confidence: 99%

Patellar Tendon Healing With Platelet-Rich Plasma

Almeida

Demange

Sobrado³

et al. 2012

Am J Sports Med

134

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Autologous platelet-rich plasma gel to reduce donor-site morbidity after patellar tendon graft harvesting for anterior cruciate ligament reconstruction: a randomized, controlled clinical study

Abstract: Prospective randomized controlled study, Level I.

Cited by 135 publications

References 25 publications

The use of platelet-rich plasma to augment conservative and surgical treatment of hip and pelvic disorders

The use of platelet-rich plasma to augment conservative and surgical treatment of hip and pelvic disorders

Travelling along the Clinical Roadmap: Developing Electrospun Scaffolds for Tendon Repair

Patellar Tendon Healing With Platelet-Rich Plasma

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