Autologous platelet-rich plasma in the treatment of venous leg ulcers in primary care: a randomised controlled, pilot study

Burgos-Alonso, Natalia; Lobato, Igone; Hernández, I.; Sebastian, Kepa San; Rodríguez, Begoña Rodríguez; March, Anna Giné; Perez-Salvador, Adriana; Arce, Veronica; García-Álvarez, Arturo; Gómez-Fernández, María Cruz; Grandes, Gonzalo; Andı́a, Isabel

doi:10.12968/jowc.2018.27.sup6.s20

Cited by 35 publications

(43 citation statements)

References 13 publications

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“…The use of autologous PRP for tissue healing and therapeutic purposes offers a safe and effective alternative to conventional treatments, without relevant side effects being patient’s own biological material [ 18 ]. In recent years, PRP gels have been used in vivo for many disorders related to healing process in wounds [ 19 , 20 , 21 , 22 , 23 , 24 , 25 ] and musculoskeletal lesions [ 18 , 26 , 27 , 28 , 29 ] both in human and veterinary medicine ( Figure 1 ). Biological (e.g., release of the active compounds) and mechanical (plasticity, modelling and resistance at the level of application site) properties of PRP gels are markedly influenced by platelet concentration and the nature of the activator.…”

Section: Introductionmentioning

confidence: 99%

Rheological Properties and Growth Factors Content of Platelet-Rich Plasma: Relevance in Veterinary Biomedical Treatments

et al. 2020

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Platelet-rich plasma (PRP) is a nontransfusional hemocomponent, considered as a powerful concentrate of growth factors (GFs) therapeutically used to stimulate tissue regeneration. The use of autologous PRP, as the patient’s own biological material, for therapeutic purposes represents a safe and effective alternative to conventional treatments in both human and veterinary medicine. The aim of this study was the characterization of canine PRP from rheological and biological points of view. Thus, a characterization of the viscoelastic properties of the PRP systems was performed in order to clarify the influence of different calcium concentrations, in the presence of autologous thrombin-rich solution, on the PRP gels’ mechanical properties, from which the applicability of these systems in biomedical treatments is strongly dependent. Then, an evaluation of the content of GFs in PRP, activated or not with thrombin, and stored at different temperatures (37 °C and −20 °C) was performed over time, outlining, for the first time, the importance of the effect of physiological temperature (37 °C) on the production of GFs. A clinical case study conducted in a dog with a complete rupture of the common calcaneal tendon (Achilles tendon) confirmed the relevance of this hemocomponent in the daily veterinary clinical activity and the potential translational value for human health.

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Section: Introductionmentioning

confidence: 99%

Rheological Properties and Growth Factors Content of Platelet-Rich Plasma: Relevance in Veterinary Biomedical Treatments

et al. 2020

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“…It is believed that PRP influences wound healing by stimulating tissue repair mechanisms, enhancing tissue healing and regeneration including bone, cartilage, tendon and muscle at various levels with minimal adverse effects (Albanese et al., 2013; Alsousou et al., 2013; Rah et al., 2017; Lang et al., 2018; Tambella et al., 2018a,b). Indeed, PRP has been used to enhance the healing process of various types of wounds (Kim et al., 2009; Alsousou et al., 2013; Picard et al., 2015; Alishahi et al., 2014; Tambella et al., 2014; Martinez-Zapata et al., 2016; Burgos-Alonso et al., 2018; Tambella et al., 2018a,b; Moneib et al., 2018), orthopaedics (Alsousou et al., 2013; Samy, 2016; Faillace et al., 2017; Marcazzan et al., 2018; Huang et al., 2019), ophthalmology (Ronci et al., 2015; Wróbel-Dudzińska et al., 2018; Alio et al., 2018), and dentistry (Del Fabbro et al., 2017; Tabrizi et al., 2018; Bhujbal et al., 2018; Saleem et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

Effects of autologous platelet-rich plasma coated sutures on intestinal anastomotic healing in rabbits

Daradka

Alardah

Ismail

2019

Heliyon

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The objective of this study was to investigate the intestinal anastomotic healing enhancing effect of platelets-rich plasma (PRP) using PRP-coated sutures in a rabbit model. A total of 30 mature male rabbits were divided into 3 groups (10 rabbits per group). Group 1 received uncoated sutures, group 2 received sodium acetate-coated sutures, and group 3 received PRP-coated sutures. Polyglactin 910 (Vicryl, USA), size 4-0 was used in all groups. Five rabbits of each group were euthanized on day 3 following the surgery while the remaining 5 rabbits were euthanized on day 10. Gross evaluation of the anastomotic site in PRP-coated sutures group demonstrated significantly (P < 0.05) lower adhesion formation scores on both days 3 and 10 of the study while in the control groups, evidence of leakage at the anastomotic site was present along with signs of haemorrhage and local inflammation. On day 10 in the control groups, there were strands of strong adhesions between the ileum, colon and cecum with large amount of fibrin deposited at the site of the anastomosis. Tissues of the anastomotic site revealed a significant level of hydroxyproline on day 10 in PRP-coated sutures group compared with control groups. Histopathological evaluation revealed significantly (P < 0.05) less inflammatory infiltration, and more angiogenesis and collagen deposition on day 10 in PRP-coated sutures group compared to the control groups. Results of this study clearly indicate promising healing enhancing effects of using PRP-coated sutures at intestinal anastomotic site with little to no obvious disadvantages.

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“…Amongst all of these, the venous ulcers are the most common form of chronic ulcers of the lower extremities, with a significant impact on quality of life and work productivity [ 4 ]. The prevalence varies between 1 and 2% in the population over 60 years of age presenting chronic venous insufficiency [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

A case series of platelet rich plasma in chronic venous ulcers

Huber¹,

Martinelli²,

Quintero³

et al. 2021

Regenerative Therapy

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Introduction Venous ulcers are the most common type of leg wounds (80%) and the main cause is chronic venous insufficiency. Autologous platelet-rich plasma (PRP) is a potential wound healing treatment due to its great variety of growth factors. The aim of this study was to describe in a case series the results of poor-leukocyte PRP (P-PRP) or saline for the treatment of chronic non-healing ulcers of the lower extremity. Methods Eight patients were treated according to the topical therapy: saline solution or P-PRP gel. All patients used double compression stocks and were assisted by a vascular practitioner for up to 12 months or until wound healing. The treatment was performed weekly with cleaning of the affected area, macroscopic evaluation (area measurement and photos) and P-PRP or saline application, and closure with Tegaderm®. Trial Registration: Retrospectively approved by Brazilian Clinical Trials, register number RBR-7zhgb3 ( http://www.ensaiosclinicos.gov.br/rg/RBR-7zhgb3/ ). Results All patients showed signs of wound healing with a reduction in wound size and ulcer numbers, but more evident with P-PRP application. Conclusions The results suggested that P-PRP presented a better result when compared to saline solution in the healing process of long clinical course chronic venous ulcers, when associated to compressive stocks and topical care.

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Autologous platelet-rich plasma in the treatment of venous leg ulcers in primary care: a randomised controlled, pilot study

Abstract: This study offers proof-of-concept of the feasibility and safety of PRP treatment to inform larger clinical trials in patients with VLUs. Our preliminary results suggest that PRP delivers a safe and effective treatment for VLU care that can be implemented in primary health-care settings.

Cited by 35 publications

References 13 publications

Rheological Properties and Growth Factors Content of Platelet-Rich Plasma: Relevance in Veterinary Biomedical Treatments

Rheological Properties and Growth Factors Content of Platelet-Rich Plasma: Relevance in Veterinary Biomedical Treatments

Effects of autologous platelet-rich plasma coated sutures on intestinal anastomotic healing in rabbits

A case series of platelet rich plasma in chronic venous ulcers

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