Autologous Platelet-Rich Plasma Infusion to Improve Pregnancy Outcome in Suboptimal Endometrium: A Review

Abstract

Over the past decade, platelet-rich plasma (PRP) has been used in several fields of medicine to promote cell growth and expedite wound healing for the treatment of arthritis, nerve injury, tendinitis, bone regeneration, cardiac muscle repair, and oral & plastic surgery. Recently, researchers have been applying autologous PRP to bolster the growth of endometrial lining in patients with a history of endometriumrelated failed embryo transfers. Evidence reveals that PRP is a rich source of active cytokines and various growth factors, which come from an autologous source that can be easily attained from peripheral blood without risk of disease transmission to the patient. In this review, several studies were analyzed that involved patients 18-42 years of age undergoing hormone replacement therapy (HRT) in preparation for embryo transfer and serial transvaginal ultrasound in conjunction with PRP infusions into the endometrium via an intrauterine insemination (IUI) catheter. Exclusion criteria included patients with endometritis, polyps, or adhesions. Embryo transfers (ET) were performed when the endometrial lining achieved a thickness of >7 mm. The database indicates that PRP infusion therapy is a promising low-cost treatment for HRT patients that significantly increases endometrial thickness and improves pregnancy success in a previous suboptimal ET patient population.Evidence shows that PRP infusion directly into the endometrium enhances lining development in patients suffering from chronically refractive or underdeveloped endometrium. Chemical pregnancy in patients that underwent PRP infusion with frozen embryo transfer was 50% (108/216) in comparison to 17.1% (16/93) in patients that did not receive PRP treatment. Innovations in Assisted Reproduction Technology 2Autologous

Platelet-Rich Plasma (PRP) for Endometrial Treatment Efficacy and Safety in Assisted Reproductive Technology: A Comprehensive Review

“…Concentrated delivery of growth factors along with TGF-β1 and PDGF works with embryo transfer strategies to improve endometrial thickness, angiogenesis, cell proliferation, and reduce inflammation. These hopeful effects have been observed with PRP [66]. This novel treatment method makes use of PRP to generate a pro-regenerative milieu in the endometrium, promoting tissue regeneration and repair which can be vital for a successful embryo implantation and pregnancy development.…”

“…The effectiveness of using PRP along with embryo transfer methods to improve endometrial receptivity and enhance pregnancy rate is supported by medical research, particularly in those with a record of RIF. Research has shown that intrauterine infusion of PRP significantly improves endometrial thickness, which is a critical factor connected to better pregnancy rates in women with less fibrosis [ 66 ]. This integrated approach affords a tailor-made and powerful technique for improving reproductive results in people who are having problems with implantation, boosting endometrial development, and setting up a favorable environment for successful embryo implantation.…”