Autologous Serum Eyedrops in the Treatment of Aniridic Keratopathy

Platelet Derivatives in Regenerative Medicine: An Update

“…The centrifugation after the clotting phase of 2-72 hours permits a good separation between serum and the clot [60,61]. The obtained serum is diluted with variable concentrations of sodium chloride 0.9% (NaCl) or/and antibiotics [62].…”

“…Platelet-derived products have shown an important role in the treatment of dry eye syndrome, dormant ulcers (epithelial defects of the cornea that fail to heal), ocular surface syndrome after Laser In Situ Keratomileusis (LASIK), and for surface reconstruction after corneal perforation associated also with amniotic membrane transplantation [61,[112][113][114][115]. Furthermore, platelet derivatives appear to show therapeutic effects in some diseases such as diabetic keratitis, keratocongiuntivite sicca, traumatic post-infectious and vernal ulcers that lead to a condition known as persistent epithelial defects [116].…”

Effect of Autologous Serum Eye Drops in Patients with Sjögren Syndrome-related Dry Eye: Clinical and In Vivo Confocal Microscopy Evaluation of the Ocular Surface

“…Matsumoto et al showed that therapy with AS eye drops, thanks to nerve growth factor and surfactant proteins, can help in healing neurotropic keratopathy by facilitating nerve healing and epithelialization (49). This is also supported by investigations carried out by Lopez-Garcia et al (50).…”

Serum eye drops, amniotic membrane and limbal epithelial stem cells—tools in the treatment of ocular surface disease

“…Clinically, serum eye drops are effective in treating conditions such as primary and secondary causes of dry eye, persistent epithelial defects (Poon et al 2001;Noble et al 2004;López-García et al 2008), neurotrophic ulcers (Matsumoto et al 2004) and following ocular surface reconstructive surgery. In the future, use of allogeneic serum preparations such as from family members, could also be advantageous for patients where autologous serum drops are not possible (Chiang .…”