Autologous serum for anterior tissue necrosis after porous orbital implant

Kamal, Saurabh; Kumar, Sushil; Goel, Ruchi

doi:10.4103/0974-9233.129776

Cited by 6 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CBS is considered a reliable source of undifferentiated mesenchymal stem cells [ 106 , 107 ], which are self-renewal elements that are able to replace directly corneal keratocytes [ 104 ] and conjunctival, limbal [ 76 ], and retinal nerve cells [ 104 ]. In addition, CBS contains consistent levels of cytokines, GFs, fibronectin, prealbumin, and fatty oils that provide useful instruments for corneal differentiation [ 74 , 108 ]. Moreover, CBS includes antibacterial agents as IgG, lysozyme, and complement but lower levels of vitamin A compared to peripheral serum [ 109 ].…”

Section: Clinical Applications and Study Resultsmentioning

confidence: 99%

Human Serum Eye Drops in Eye Alterations: An Insight and a Critical Analysis

Pascale¹,

Lanza

Sommese³

et al. 2015

Journal of Ophthalmology

View full text Add to dashboard Cite

Human serum contains a physiological plethora of bioactive elements naturally released by activated platelets which might have a significant effect on the regeneration of corneal layers by stimulating the cell growth. This mechanism supported the use of human serum eye drops in some ocular diseases associated with dystrophic changes and alterations of the tear film, such as persistent corneal epithelial defects and dry eye syndrome. We focused our effort on potential benefits and limitations of the use of human serum eye drops when conventional therapies failed. We reviewed the recent literature by reporting published studies from 2010 to 2014. Despite the limited evaluated study populations, most of the clinical studies have confirmed that serum eye drop therapy is effective in corneal healing by reducing ocular symptom, particularly during the short-term follow-up. In addition, three recent published studies have shown the efficacy of the serum eye drop therapy in comparison to traditional ones in intractable patients. Besides, reported ongoing clinical studies confirmed the open debate regarding the use of biologic tools for cornea regeneration. Results from these studies might open novel challenges and perspectives in the therapy of such refractory patients.

show abstract

Section: Clinical Applications and Study Resultsmentioning

confidence: 99%

Human Serum Eye Drops in Eye Alterations: An Insight and a Critical Analysis

Pascale¹,

Lanza

Sommese³

et al. 2015

Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…A recently published case series reported that autologous serum promoted wound healing and prevented tissue necrosis after PP implantation. 40 Autologous PL may be used to prevent tissue necrosis and PP implant exposure.…”

Section: Discussionmentioning

confidence: 99%

Effect of Allogeneic Platelet Lysate and Cyanoacrylate Tissue Glue on the Fibrovascularization of the Porous Polyethylene Implant

Öztürk

Şahi̇n

Tas

et al. 2016

Journal of Craniofacial Surgery

View full text Add to dashboard Cite

Because of limited autogenous tissue sources, donor site morbidity, and difficulty of shaping the autologous tissue, surgeons often need to use alloplastic frameworks in reconstruction of 3-dimensional tissue defects. Synthetic porous polyethylene (PP) implant is widely used in plastic surgery for 3-dimensional reconstruction of the lost or highly deformed tissues. One of the main factors of PP implant exposure is delayed fibrovascular ingrowth. In the present study, the authors investigated the effect allogeneic plateletlysate (PL) and cyanoacrylate tissue glue (CTG) (2-octyl cyanoacrylate) on the fibrovascularization of the PP implant.Twenty adult female Wistar rats were divided into 4 groups equally, according to the different surgical techniques and implanted materials used. Only PP implant was implanted subcutaneously through a skin incision on the chest wall skin of the rats in the control group; however, CTG was applied with PP implant in the cyanoacrylate group, PL was applied with PP implant in the platelet group, CTG and platelet was applied together with PP implant in the combination group. All of the implants in each group were histologically assessed at postoperative second week. Determination of the collagen density in the tissues, inflammation, and necrosis and vascularization status was assessed semiquantitatively.A denser collagen structure, low inflammation, and necrosis were found in PL groups. There was, however, a significant decrease in vascular density with PL-treated groups. PL treatment may have a potential to reduce complications related to PP implants.

show abstract

“…[26][27][28] Autologous serum has been used over the last two decades to promote the healing of epithelial and cartilaginous damage of both known and unknown aetiologies. 13,[29][30][31] At the same time, it includes various immunoglobulins (e.g. immunoglobulin G and immunoglobulin A) and lysozyme.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic and protective effects of autologous serum in amikacin-induced ototoxicity

et al. 2017

View full text Add to dashboard Cite

Objective: Possible therapeutic and protective benefits of intratympanic autologous serum application in amikacininduced ototoxicity were investigated.Methods: Twenty-four guinea pigs were separated equally into two groups: therapeutic (group A) and protective (group B). Transient evoked otoacoustic emissions were recorded before and after autologous serum application. Apoptotic cells were identified in the organ of Corti, spiral limbus and spiral ganglion by the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling ('TUNEL') method.Results: Transient evoked otoacoustic emission responses at 1, 1.4 and 2.8 kHz improved without significance after autologous serum application in group A ( p > 0.05). A significantly protective effect of autologous serum was determined at 4 kHz in group B ( p < 0.05). There were significantly fewer apoptotic cells at the spiral limbus in the therapeutic and protective groups compared to the control group ( p < 0.05).Conclusion: Autologous serum may offer protection against ototoxicity-induced hearing loss, but it cannot restore hearing. Immunohistochemically, autologous serum significantly decreases activation of the intrinsic pathway of pro-apoptotic signalling in mesenchymal cells compared to neurons and neurosensory cells.

show abstract

Autologous serum for anterior tissue necrosis after porous orbital implant

Cited by 6 publications

References 5 publications

Human Serum Eye Drops in Eye Alterations: An Insight and a Critical Analysis

Human Serum Eye Drops in Eye Alterations: An Insight and a Critical Analysis

Effect of Allogeneic Platelet Lysate and Cyanoacrylate Tissue Glue on the Fibrovascularization of the Porous Polyethylene Implant

Therapeutic and protective effects of autologous serum in amikacin-induced ototoxicity

Contact Info

Product

Resources

About