Autologous Skin Cell Suspension Application for Toxic Epidermal Necrolysis: A Case Report

Abstract

Toxic epidermal necrolysis is a drug-mediated disease process which mimics a partial thickness thermal injury. It has long been treated with frequent wound dressing changes and supportive care. There has been minimal efficacious system therapy. The pathophysiology is poorly understood but causes necrosis of keratinocytes at the dermal-epidermal junction leading to sloughing of the epidermis. The disease is rare with high mortality rates associated with long hospital stays. This case report describes the application of autologous skin cell suspension to a patient with toxic epidermal necrolysis after antihypertensive and hyperglycemic therapy. This was associated with minimal wound care and efficacious arrest of patient disease process and timely closure of wound.