Autologous Tissue Reconstruction of Ventral Hernias in Morbidly Obese Patients

Abstract

Hypothesis: Separation of components is a safe and effective technique for abdominal wall reconstruction in morbidly obese patients.Design: Review of a prospectively accumulated database.Setting: University tertiary care medical center.Patients: Thirty morbidly obese patients who underwent ventral hernia repair using the separation of components technique between

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“…[5][6][7] The effects of immunosuppression and renal transplant on wound healing have been welldocumented. [7][8][9][10][11][12][13][14][15][16][17][18] Corticosteroids play an important role in the development of incisional hernias by impeding wound healing. [8][9][10][11][12][13][14][15][16][17][18] During acute rejection, when higher doses of methylprednisolone (1 g/day) are administered, steroids have been shown to have considerable effects on the development of incisional hernias.…”

“…[7][8][9][10][11][12][13][14][15][16][17][18] Corticosteroids play an important role in the development of incisional hernias by impeding wound healing. [8][9][10][11][12][13][14][15][16][17][18] During acute rejection, when higher doses of methylprednisolone (1 g/day) are administered, steroids have been shown to have considerable effects on the development of incisional hernias. [8][9][10][11] Use of mycophenolate mofetil, tacrolimus (Astellas Pharma, Chuo-ku, Japan), and sirolimus (Pfizer, Groton, CT, USA) for immunosuppression has been shown to be significant risk factors for hernias.…”

“…[8][9][10][11] Use of mycophenolate mofetil, tacrolimus (Astellas Pharma, Chuo-ku, Japan), and sirolimus (Pfizer, Groton, CT, USA) for immunosuppression has been shown to be significant risk factors for hernias. [12][13][14][15][16][17][18] Mycophenolate mofetil has been shown to have an antiproliferative effect that may interfere with the healing of the muscles and fascia. [12][13][14][15][16][17][18] Surgical site infection (SSI) plays a prominent role in the development of incisional hernias.…”

“…[12][13][14][15][16][17][18] Mycophenolate mofetil has been shown to have an antiproliferative effect that may interfere with the healing of the muscles and fascia. [12][13][14][15][16][17][18] Surgical site infection (SSI) plays a prominent role in the development of incisional hernias. Several studies have shown that SSI is the most important risk factor for hernia development.…”

“…Several studies have shown that SSI is the most important risk factor for hernia development. 1,[6][7][8][9][10][11][12] The negative effects of immunosuppressive therapy after renal transplant can further contribute to the high incidence of SSI, leading to increased incidence of incisional hernias due to disturbed and delayed wound healing.…”