Autologous Transplant of Submandibular Gland as a Source of Tears: Demonstration of Function on Tc-99m Pertechnetate Scintigraphy

The timing of acid-induced increase in saliva secretion in transplanted submandibular glands

“…Autologous microvascular transplantation of the submandibular gland (SMG) has proven to be an effective treatment for patients with severe KCS. [1][2][3][4][5][6][7][8][9][10] In our experience of SMG transplantation in 180 patients (195 glands), all viable transplanted SMGs retain their secretion function in the long term and the symptoms of dry eye are greatly relieved. 3,8 However, excessive secretion, or epiphora, occurs in more than 40% of patients at >6 months after surgery.…”