2019
DOI: 10.3892/ijo.2019.4923
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Autologous tumor‑derived microvesicles influence gene expression profiles and enhance protumorigenic chemotactic potential, signal transduction and cellular respiration in gastric cancer cells

Abstract: Tumor-derived microvesicles (TMVs) interact with a variety of different cell types within the immune system, including lymphocytes, monocytes, dendritic cells and tumor cells that they have originated from. In the present study, the effects of autologous-TMVs (auto-TMVs) on gene expression, chemotaxis, intercellular signaling and cellular metabolism were examined in cells of the gastric cancer (GC) cell line 1415 (GC1415). The effects of auto-TMVs on mRNA gene expression in GC1415 cells were assessed using pat… Show more

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Cited by 4 publications
(3 citation statements)
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“…Our results obtained in the simple chamber chemotaxis assay indicated a slight chemoattractant activity of TEVs. This is in concurrence with the study by Szatanek et al (2020), who have shown, by using a more sophisticated cell movement tracking analysis, that tumour cells migrate towards their increasing auto-TEV gradient in vitro (the tumour cell movement was more orderly and faster in the presence of TEVs).…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…Our results obtained in the simple chamber chemotaxis assay indicated a slight chemoattractant activity of TEVs. This is in concurrence with the study by Szatanek et al (2020), who have shown, by using a more sophisticated cell movement tracking analysis, that tumour cells migrate towards their increasing auto-TEV gradient in vitro (the tumour cell movement was more orderly and faster in the presence of TEVs).…”
Section: Discussionsupporting
confidence: 92%
“…Ristorcelli et al (2009) concluded that nanoparticles derived from tumour cells exert pleiotropic effects on cells, as they may activate the phosphatidylinositol 3-kinase/ protein kinase B (PI3K/Akt) survival pathway or induce phosphatase and tensin homolog deleted on chromosome ten (PTEN) and glycogen synthase kinase 3 (GSK-3) activities leading cells towards apoptosis. We fully agree with such statements, as an autocrine loop in tumour growth is still unclear and further studies focusing on the role of TEVs in this process are necessary (Szatanek et al, 2020).…”
Section: Discussionsupporting
confidence: 78%
“…At present, MVs have not been fully studied in GC, but some studies showed that specific MVs can influence GC or can be used as markers of GC [ 21 23 ]. Malgorzata Stec et al .…”
Section: Discussionmentioning
confidence: 99%