2023
DOI: 10.1007/s10571-023-01332-w
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Autolysis Affects the Iron Cargo of Ferritins in Neurons and Glial Cells at Different Rates in the Human Brain

Abstract: Iron is known to accumulate in neurological disorders, so a careful balance of the iron concentration is essential for healthy brain functioning. An imbalance in iron homeostasis could arise due to the dysfunction of proteins involved in iron homeostasis. Here, we focus on ferritin—the primary iron storage protein of the brain. In this study, we aimed to improve a method to measure ferritin-bound iron in the human post-mortem brain, and to discern its distribution in particular cell types and brain regions. Th… Show more

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Cited by 2 publications
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“…Moreover, nuclear size is influenced by mechanical forces, cytoskeletal integrity, and calcium homeostasis (24). These factors are also likely perturbed after somatic death of the organism (3,25,26). The nature of histological changes was similar in all the animals of the study and increased in intensity over time, reinforcing the idea that postmortem changes are irreversible, predictable, and progressive (2).…”
Section: Discussionmentioning
confidence: 76%
See 1 more Smart Citation
“…Moreover, nuclear size is influenced by mechanical forces, cytoskeletal integrity, and calcium homeostasis (24). These factors are also likely perturbed after somatic death of the organism (3,25,26). The nature of histological changes was similar in all the animals of the study and increased in intensity over time, reinforcing the idea that postmortem changes are irreversible, predictable, and progressive (2).…”
Section: Discussionmentioning
confidence: 76%
“…Moreover, nuclear size is influenced by mechanical forces, cytoskeletal integrity, and calcium homeostasis ( 24 ). These factors are also likely perturbed after somatic death of the organism ( 3 , 25 , 26 ).…”
Section: Discussionmentioning
confidence: 99%