Autolysis and Atrophy

Bradley, H. C.

doi:10.1152/physrev.1922.2.3.415

Cited by 42 publications

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“…Alny relative dlecrease in the formiier or inicrease in the latter could lead to a cellular-(lisinitegration wlhich morphologically would conlsist of niecrosis or atrophy. Of the various bo(ly tissues whliclh lhave beeni studied, the hlighest rates of intracellular proteolysis lhave been found in liver and kidney (15). The (19).…”

Section: Discussionmentioning

confidence: 99%

Cirrhosis of the Liver Among Rats Receiving Diets Poor in Protein and Rich in Fat 1

Webster¹

1942

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 99%

Cirrhosis of the Liver Among Rats Receiving Diets Poor in Protein and Rich in Fat 1

Webster¹

1942

J. Clin. Invest.

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“…But when the necrotic mass is small the factor of interchange assumes great importance, as the experiments with the skin grafts show. The occurrences subsequent to the injury of small cell aggregates cannot be explained on the basis that a local accumulation of acids determines autolysis or atrophy (23), for the sufficient reason that the local reaction will tend toward alkalinity rather than toward the acidity of vigorous tissue surviving an ischemia. It follows that the chemical changes which take place in small necroses must differ in some respects from those occurring in large masses of dead tissue.…”

Section: Discussionmentioning

confidence: 99%

The Relative Reaction Within Living Mammalian Tissues

Rous

1926

Journal of Experimental Medicine

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By means of vital staining with indicators a study has been made of the changes in reaction and in certain other attributes of a tissue abruptly rendered ischemic. Grafts of mouse skin have been employed as test material. It has been found that almost at once after implantation vigorous grafts become notably acid as compared with the normal skin and that they survive and "take" despite the acid condition, which remains at a maximum for several days. Weak or injured grafts on the contrary tend to be as alkaline as their surroundings, if not more so. Through experiments directed to the purpose reasons for this difference have been found in the lessened metabolic activities of the cells of the injured skin, and in an increased permeability which leads to a generalized suffusion of the damaged tissue with the alkaline lymph and an abnormally rapid escape of carbon dioxide from it. The influence of these factors to determine the reaction of tissues dying within the body has not been sufficiently taken into account in considering the chemical changes that occur after cell death, and some revision of current views regarding these as they affect small necrotic masses would seem called for. Carbon dioxide penetrates so readily into the living skin as to cause some local increase in the hydrogen ion concentration within cutaneous regions exposed to an atmosphere of it, even when the local circulation and the ventilation by way of the lungs have not been interfered with. It penetrates injured skin with especially great ease. Tissue acidosis and edema not infrequently occur together; but no relationship between them of cause and effect has been made out.

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“…(6) Does the skin possess resident proteoclastic enzymes like other tissues? (7) If so, what chemical entities 1 Received June 4, 1931. Presented before the American Society of Biological Chemists, Montreal, Que., April 9, 1931.…”

Section: Literature Citedmentioning

confidence: 99%

The Chemistry of the Integument I—Fresh Catskin and Its Post-Mortem Changes^1,2

Morse¹

1931

Ind. Eng. Chem.

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INDUSTRIAL AND ENGINEERING CHEMISTRY 1475With a pure gum compound the progressive effect of strain is not as pronounced as in a tread compound. It appears rather that a small initial strain affects the whole of the stress-strain curve. RemarksThe data given show the elusive character of the stressstrain curve of rubber. The initial-stretch curve, which is ordinarily used in evaluating a rubber compound, is possibly the most definite but it is interesting to note that it is the curve least permanent in character. It apparently cannot be retraced after the rubber has once been stretched. If the stress-strain curve is to be used in designing rubber compounds for specific purposes, it is obvious that the conventional curve may not give the proper stress-strain relations.A study of the phenomena encountered in the repeated stressing of rubber, taking into consideration different compounding ingredients, different degrees of vulcanization, etc., should throw light on the structure of rubber compounds and on the behavior of different compounding ingredients in them. This work indicates that the lower part of the stress-strain curve, which is seldom accurately determined, may have an important bearing on the real properties of a compound.The apparatus described was constructed primarily for investigational studies, but the speed and ease with which a stress-strain record of a rubber sample is made suggests the use of a machine of this type for certain classes of routine testing. ConclusionsThe stress-strain relations of a sample of rubber are very markedly affected by the previous strain history.Rubber will recover to some extent from the effects of a strain, but not completely.In a rubber compound, such as tread stock, a series of increasing strains has a pronounced progressive action, each increase in strain producing added effects.The conventional stress-strain curve does not represent the permanent characteristics of a rubber compound.

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Autolysis and Atrophy

Cited by 42 publications

References 0 publications

Cirrhosis of the Liver Among Rats Receiving Diets Poor in Protein and Rich in Fat 1

Cirrhosis of the Liver Among Rats Receiving Diets Poor in Protein and Rich in Fat 1

The Relative Reaction Within Living Mammalian Tissues

The Chemistry of the Integument I—Fresh Catskin and Its Post-Mortem Changes^1,2

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Autolysis and Atrophy

Cited by 42 publications

References 0 publications

Cirrhosis of the Liver Among Rats Receiving Diets Poor in Protein and Rich in Fat 1

Cirrhosis of the Liver Among Rats Receiving Diets Poor in Protein and Rich in Fat 1

The Relative Reaction Within Living Mammalian Tissues

The Chemistry of the Integument I—Fresh Catskin and Its Post-Mortem Changes1,2

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The Chemistry of the Integument I—Fresh Catskin and Its Post-Mortem Changes^1,2