Autolysis: mechanisms of action in the removal of devitalised tissue

Atkin, Leanne; Rippon, Mark

doi:10.12968/bjon.2016.25.20.s40

Cited by 42 publications

(13 citation statements)

References 34 publications

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“…Autolytic debridement is a selective process, where only necrotic tissue is dissolved to accelerate healing (Table 1). 26 Table 1. A moist wound environment has several benefits that result in faster and better quality of healing…”

Section: Introductionmentioning

confidence: 99%

Moist Wound Healing with Commonly Available Dressings

Nuutila

Eriksson

2021

Advances in Wound Care

246

110

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Significance: A moist wound environment has several benefits that result in faster and better quality of healing. It facilitates autolytic debridement, reduces pain, reduces scarring, activates collagen synthesis, facilitates and promotes keratinocyte migration over the wound surface, and supports the presence and function of nutrients, growth factors, and other soluble mediators in the wound microenvironment. Recent Advances: Wound dressings can be utilized to create, maintain, and control a moist environment for healing. Moist wound dressings can be divided into films, foams, hydrocolloids, hydrogels, and alginates. We are also including negative pressure wound therapy systems in the moist dressings. Critical Issues: An optimal wound dressing should provide a moist environment and have an optimal water vapor transmission rate (WVTR) and absorptive capacity. It should also protect the wound against trauma and contamination and be easy to apply, painless to remove, and esthetically acceptable or even pleasing. Future Directions: Interventions, particularly dressing changes, by medical caregivers are labor intensive and expensive and there should be a continuous effort to reduce their number per week. Smart dressings with integrated microsensors and delivery capabilities that would allow wireless real-time monitoring and treatment of the wound would be very advantageous. This way the state of the wound as well as the wear time of the dressing could be assessed without dressing removal or visit to the wound care center. In addition, an ability to adjust the WVTRs to the exudate level of the wound (or having a large absorptive capacity without changing the WVTR) would be useful. This feature would guarantee an optimal level of hydration of the wound surface throughout the treatment.

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Section: Introductionmentioning

confidence: 99%

Moist Wound Healing with Commonly Available Dressings

Nuutila

Eriksson

2021

Advances in Wound Care

246

110

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“…Na CMC, gelatin, and pectin have also been widely applied as drug‐delivery carriers, particularly to modify the release of drugs, including prednisolone . However, there has been no investigation into the bioavailability of prednisolone presented as a physical mix with the three polymers in combination.…”

Section: Discussionmentioning

confidence: 99%

“…Daily reapplication of the prednisolone: hydrocolloid powder mix further ensures a continual drug pool for the wound site. Hydrocolloids are also known to have an autolytic component in the wound‐healing process, thereby facilitating the removal of non‐viable tissue and promoting a healthy wound bed . In addition, pectin and Na CMC, being anionic polymers, could regulate the wound pH to provide an acidic environment that is conducive to wound healing…”

Section: Discussionmentioning

confidence: 99%

A novel topical therapy for resistant and early peristomal pyoderma gangrenosum

Pearson

Prentice

Sinclair

et al. 2019

International Wound Journal

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Peristomal pyoderma gangrenosum (PPG) is an under‐recognised and difficult condition to treat. We describe a case series using a novel topical combination therapy that promotes wound healing and allows for adhesion of the stoma appliance. A crushed oral prednisolone tablet mixed with Stomahesive Protective Powder (ConvaTec) was applied topically to seven patients with PPG and resulted in pain relief and wound healing in six of seven patients. Only one patient experienced recurrence. The novel topical therapy we describe is cost‐effective, readily available, and easily applied in any inpatient or outpatient setting.

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“…It is not indicated for wounds with areas of extensive necrosis, because it is less efficient. 17 , 18 …”

Section: Wound Debridement (Letter T Of Time)mentioning

confidence: 99%

Fundamental aspects of the local approach to cutaneous ulcers

Colenci

Abbade

2018

An. Bras. Dermatol.

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Ulcers or wounds can be classified as acute or chronic. Their treatment involves overall assessment of the patient and choice of suitable local therapy, and the appropriate indication and use of products. Technological progress in the field of wound treatment has increased rapidly. Constant updating, with emphasis on available scientific evidence, is necessary to offer the best approaches to patients with acute and chronic wounds. A qualitative analysis of literature was conducted to identify scientific publications that update the concepts involved in local wound treatment, to present some resources that can aid the healing process and describe the different types of dressings available. This review includes wound assessment using the acronym TIME (tissue, infection/inflammation, moisture balance and edge of wound), cleaning and debridement, infection/inflammation control, exudate control, dressing types and main indications.

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Autolysis: mechanisms of action in the removal of devitalised tissue

Cited by 42 publications

References 34 publications

Moist Wound Healing with Commonly Available Dressings

Moist Wound Healing with Commonly Available Dressings

A novel topical therapy for resistant and early peristomal pyoderma gangrenosum

Fundamental aspects of the local approach to cutaneous ulcers

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