Automated Analysis of Anterior Chamber Inflammation by Spectral-Domain Optical Coherence Tomography

Comparison of time-domain, spectral-domain and swept-source OCT in evaluating aqueous cells in vitro

“…Many kinds of commercial OCTs were available in clinic to evaluate the anterior segment of eyeball (Agarwal et al, 2009;Igbre et al, 2014;Kumar et al, 2014;Li et al, 2013;Sharma et al, 2015). We only chose three commercial OCTs in this study, which represent three kinds of OCTs.…”

“…RTVue XR Avanti OCT is a SD-OCT with the highest A-scan speed among three OCTs we used which has never been employed in discerning aqueous cells. However, one study showed that RTVue-100 (Optovue Inc, USA) can be used to image and grade aqueous cells in vivo (Sharma et al, 2015), and clinical grading strongly correlates with the number of cells in OCT image. RTVue XR Avanti OCT is an upgraded version of RTVue-100, with higher A-scan speed.…”

“…There are several ways to quantify the aqueous cells, including slit-lamp biomicroscopy (Jabs et al, 2005), ultrasound biomicroscopy (UBM) (Peizeng et al, 2009), laser flare photometry (Ladas et al, 2005) and optical coherence tomography (OCT) (Agarwal et al, 2009;Igbre et al, 2014;Kumar et al, 2014;Li et al, 2013;Sharma et al, 2015).…”

“…These researches showed anterior segment OCT (AS-OCT) can detect anterior chamber inflammatory cells in patients with uveitis (Agarwal et al, 2009;Igbre et al, 2014;Li et al, 2013;Sharma et al, 2015) or post ocular operation (Kumar et al, 2014). In addition, AS-OCT has also been used to quantitatively assess the anterior chamber cells in a small rodent model of uveitis (Pepple et al, 2016).…”

“…Time-domain OCT (TD-OCT) (Li et al, 2013) and spectral-domain OCT (SD-OCT) (Sharma et al, 2015) have been used in previous studies. Recently, swept-source OCT (SS-OCT) (Baskaran et al, 2013) was available.…”