Automated and objective measures of gait dynamics in camptocormia Parkinson’s Disease subthalamic deep brain stimulation

Soares, Carolina; Vilas-Boas, Miguel; Lopes, Elodie Múrias; Choupina, Hugo Miguel Pereira; Soares-dos-Reis, Ricardo; Fitas, Diogo; Cunha, João Paulo Silva; Monteiro, Pedro; Linhares, Paulo; Rosas, Maria José

doi:10.1016/j.clineuro.2019.105537

Cited by 4 publications

(5 citation statements)

References 28 publications

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“…We found 32 studies on the effect of DBS on PA in PD, including 723 patients. 37.5 % (n = 12) were retrospective observational before-after studies [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , 40.6 % (n = 13) were Case Reports [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] , 18.75 % (n = 6) were Case Series [77] , [78] , [79] , [80] , [81] , [82] , and 1 was a Case-control study [83] . Twenty-seven studies evaluated the effect of bilateral subthalamic DBS (STN-DBS) [52] , [70] , [71] , [54] , [55] , [56] , [57] , [58] , [59] , [61] , [62] , [63] , [64] , [66] , [67] , [68] , [73] , [74] , [75] , [77] , [78] , [79] , [80] , [81] , [82] , [83] , [84] , six studies the effect of bilateral globus pallidus par interna DBS (GPi-DBS) [53] , [65] , …”

Section: Resultsmentioning

confidence: 99%

“…The cognitive status at baseline was reported as exclusion criteria in 5 studies, and in 2 studies, there was a report of MMSE. Outcome measures differed across studies, with 16 studies using the angle of spine flexion [59] , [61] , [63] , [65] , [68] , [69] , [71] , [74] , [77] , [78] , [81] , [52] , [53] , [54] , [55] , [56] , 13 using a clinical evaluation [64] , [66] , [67] , [70] , [72] , [73] , [75] , [76] , [77] , [80] , [83] , [84] , [85] , 10 using the UPDRS score [52] , [54] , [58] , [62] , [63] , [69] , [75] , [77] , [79] , [81] , 1 using the BFMDRS score [79] , and 1 using the Cobb angle and the C7SVA (C7 sagittal vertical axis) [57] . In 81.25 % of studies (n = 26), an improvement in PA was reported.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Treatment of axial postural abnormalities in parkinsonism disorders: A systematic review of pharmacological, rehabilitative and surgical interventions

Gandolfi,

Geroin,

Imbalzano

et al. 2024

Clinical Parkinsonism & Related Disorders

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Treatment of axial postural abnormalities in parkinsonism disorders: A systematic review of pharmacological, rehabilitative and surgical interventions

Gandolfi,

Geroin,

Imbalzano

et al. 2024

Clinical Parkinsonism & Related Disorders

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“…This highlights the need for further research to confirm these results and determine the role of subthalamic DBS in the treatment of postural control in patients with PD. Soares et al (2019) investigates the effects of subthalamic DBS on gait dynamics in patients with Parkinson's disease who have camptocormia. Camptocormia is a condition characterized by an exaggerated curvature of the spine, which can affect the patient's ability to walk normally.…”

Section: Discussionmentioning

confidence: 99%

Deep Brain Stimulation (Dbs) in Patients With Parkinson's Disease: An Integrative Review on Effectiveness, Indications and Complications

Santos,

Managna,

Amorim

et al. 2023

JHS

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The objective of this integrative review is to present a critical and up-todate analysis of the evidence available in the literature on the efficacy, indications and complications of the DBS procedure in patients with PD.Methodology: For this integrative review, the search was in indexed databases such as PubMed, Scopus and Web of Science, using a combination of keywords related to the terms "deep brain stimulation", "Parkinson's Disease" and their variations. Results: After the complete analysis, 8 studies that met the established inclusion criteria were included in the systematic review table. Based on the studies, DBS is an effective treatment option for patients with advanced Parkinson's disease who do not respond adequately to drug treatment. It can produce benefits by significantly reducing chronic pain, improving postural disorders and being an effective therapeutic option for patients with camptocormia related to Parkinson's disease. These results suggest that DBS may be an important treatment option for patients with advanced Parkinson's disease. Conclusion: DBS has been shown to be a promising alternative for the treatment of PD, especially for patients who can no longer control their symptoms with conventional medications. Research is needed to improve DBS techniques and evaluate the long-term benefits of deep brain stimulation in PD patients.

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“…The exclusion criteria were: (1) Review article; (2) Articles with missing or non-extractable data; (3) Duplicate articles or those with repeat clinical data. Twenty studies containing a total of 152 patients [3,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] met all of the criteria and were included in the analysis. Three studies used globus pallidus internus deep brain stimulation (GPi-DBS), 16 used subthalamic nucleus deep brain stimulation (STN-DBS), and one study used both (Fig.…”

Section: Selection Of Studies For Analysismentioning

confidence: 99%

“…Information extracted from the selected papers included authors, year of publication, type of research, number of participants, age, gender, PD duration, camptocormia duration, bending angles (in both On and Off periods), the Unified Parkinson's Disease Rating Scale III (UPDRS-III) score (in both On and Off periods), mean follow-up time, and the L-dopa equivalent daily dose (LEDD) assessed both pre-and post-DBS (Tables 1,2, Ref. [3,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]).…”

Section: Data Extractionmentioning

confidence: 99%

Efficacy of Deep Brain Stimulation for Camptocormia in Parkinson's Disease: A Systematic Review and Meta-Analysis

Wang¹,

McClements²,

Zhao³

et al. 2023

J. Integr. Neurosci.

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Background: Camptocormia is one of the most common postural disorders of Parkinson's disease (PD) which has limited treatment options. In this review, we summarize the efficacy of deep brain stimulation (DBS) for camptocormia in PD. Methods: The PubMed (ht tps://pubmed.ncbi.nlm.nih.gov/) and EMBASE databases (https://www.embase.com/) were searched for the terms "Parkinson Disease" and "camptocormia" in combination with "deep brain stimulation". We then explored the efficacy of DBS for camptocormia by statistical analysis of the bending angle, the Unified Parkinson's Disease Rating Scale III (UPDRS-III) and L-dopa equivalent daily dose (LEDD), and by evaluating the prognosis after DBS. Results: Twenty articles that reported results for 152 patients were included in this review. These comprised 136 patients from 16 studies who underwent subthalamic nucleus deep brain stimulation (STN-DBS), and 13 patients from 3 studies who underwent globus pallidus internus deep brain stimulation (GPi-DBS). One study used both STN-DBS (2 patients) and GPi-DBS (one patient). After 3-21 months of follow-up, the mean bending angle during the Off-period was significantly reduced compared to pre-DBS (31.5 ± 21.4 vs. 53.6 ± 22.7, respectively; p < 0.0001). For the STN-DBS trials, the mean post-operative bending angles during both Off-and On-periods were significantly reduced compared to pre-operative (32.1 ± 22.7 vs. 55.4 ± 24.1, p = 0.0003; and 33.1 ± 21.5 vs. 43.7 ± 20.6, p = 0.0003, respectively). For GPi-DBS, the mean bending angle post-DBS during the Off-period was considerably lower than pre-DBS (28.5 ± 10.7 vs. 42.9 ± 9.9, p < 0.001). The decrease in bending angle after DBS was negatively correlated with the duration of camptocormia (R = -0.433, p = 0.013), whereas positively associated with the pre-bending angle (R = 0.352, p = 0.03). Conclusions: DBS is an effective treatment for camptocormia in PD. Patients in the early stage of camptocormia with more significant bending angle may benefit more from DBS.

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Automated and objective measures of gait dynamics in camptocormia Parkinson’s Disease subthalamic deep brain stimulation

Cited by 4 publications

References 28 publications

Treatment of axial postural abnormalities in parkinsonism disorders: A systematic review of pharmacological, rehabilitative and surgical interventions

Treatment of axial postural abnormalities in parkinsonism disorders: A systematic review of pharmacological, rehabilitative and surgical interventions

Deep Brain Stimulation (Dbs) in Patients With Parkinson's Disease: An Integrative Review on Effectiveness, Indications and Complications

Efficacy of Deep Brain Stimulation for Camptocormia in Parkinson's Disease: A Systematic Review and Meta-Analysis

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