Automated calculation of stenosis diameters from the width of the velocity jet with the use of a multi-gate pulsed doppler system

Compliance mismatch between prosthetic vascular replacement (possibly stented) and native artery is considered to be an important factor in implant failure due, e.g., to vascular remodeling, tissutal growth or intimal hyperplasia (IH). From an in vivo study involving altered vascular mechanics (and, consequently, compliance mismatch), carried out using the Moncada model of atherosclerosis development and smooth muscle cell (SMC) proliferation, the hemodynamic assessment was followed by means of real-time multigated ultrasound profilometry, of collared carotid artery using two different models: non-constrictive and constrictive plastic collars, wrapped around the vessel. The experiments provided the real-time measurement of velocity profiles in vivo and the subsequent estimation of wall shear stresses, locally responsible for the altered hemodynamics. Endothelium modifications were correlated with local hemodynamic alterations by using statistical regression analysis of the development of intimal hyperplasia and the mechanical stimulus applied to the endothelium by means of the two different manipulation models. Different correlations were found between wall shear rate and IH in the two models, showing the importance of the vascular pulsatility in determining SMC proliferation. This result could be useful in minimizing the negative consequences of clinical interventions such as graft and/or stent implantation.

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Pulsatile Flow and Atherogenesis: Results from in Vivo Studies

Grigioni

Daniele

D’Avenio

et al. 2001

Int J Artif Organs

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Automated calculation of stenosis diameters from the width of the velocity jet with the use of a multi-gate pulsed doppler system

Cited by 1 publication

References 13 publications

Pulsatile Flow and Atherogenesis: Results from in Vivo Studies

Pulsatile Flow and Atherogenesis: Results from in Vivo Studies

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