“…2021, 21, x FOR PEER REVIEW 16 of 39IoT Application Solutions[77,78,[139][140][141][142][143][144][145][146][147]:• Intelligent systems, sensors, IoT, technologically advanced medical devices, communications networks, etc., represent a significant improvement in the synergies between medical centers in vulnerable countries and advanced healthcare centers in developed countries.•In recent months, it has been proven that technological systems and IoT applications are of great importance in the research, application, and prevention of diseases and pandemics worldwide, when it comes to vaccine and drug manufacturing, logistics, population vaccination planning and management, data management, and patient monitoring at home, among other efforts.•Traffic accident prevention and control systems have an ally in technological systems and advanced IoT applications, for example, in user applications that inform and warn of vehicle congestion in cities and highways, accident warnings, alarm systems in adverse weather situations, among others.•Development of efficient and high-quality vaccines, where sensor applications, IoT, and intelligent systems play a great role. Technology, in all its fields, has a fundamental mission for the effective development and distribution of vaccines to the entire population, with applications to data management, including patient data, vaccination control, health and safety, among others.•In the area of air and soil pollution and the detection of chemical elements in the environment, there are multiple applications of sensors and intelligent systems that detect, transmit, manage, and prevent such problems.…”