Automated Computation of Glycemic Index for Foodstuffs Using Continuous Glucose Monitoring

Chlup, Rudolf; Seckar, Pavel; Zapletalová, Jana; Langová, Kateřina; Kudlová, Pavla; Chlupová, Karolina; Bártek, J; Jelenová, D.

doi:10.1177/193229680800200110

Cited by 10 publications

(13 citation statements)

References 27 publications

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“…Using the software program DEGIF XL for GI determination made GI calculation easy and fast. 19,38 The CGMS sensors were well tolerated in all subjects, even when used continuously for more than three days. 34,39 The strength of this pilot study is that it demonstrates the subject-related glycemic effects of OAD therapy.…”

Section: Discussionmentioning

confidence: 99%

“…[34][35][36][37] The fact that test meals were eaten both for breakfast and for dinner led to a higher number of tests in one test period. 19 In addition, at-home food testing provided a more relaxed atmosphere for all subjects compared to the traditional laboratory setting. Using the software program DEGIF XL for GI determination made GI calculation easy and fast.…”

Section: Discussionmentioning

confidence: 99%

“…25 To our knowledge, data on the influence of OAD on the GI of foods have not been reported. Specific methodologies 7,19,26,27 applied in different centers (e.g., capillary versus venous blood versus interstitial fluid sampling) make comparison of GIs more difficult. Interindividual and intraindividual variability of GIs also contribute to differences in GI values.…”

Section: Discussionmentioning

confidence: 99%

“…19,20 The IAUC (Figure 2) was determined using calculus (integration, as the sum of the all 24 trapezoid areas) according to the formula IAUC = Si, i = 1,…, 24, where Gi is the glucose concentration at a particular time, G 0 is the starting glucose concentration; and Dt = 5 min for Gi < G 0 , Si = 0.…”

Section: Calculation Of the Glycemic Index And Statistical Analysismentioning

confidence: 99%

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Influence of Oral Antidiabetic Drugs on Hyperglycemic Response to Foods in Persons with Type 2 Diabetes Mellitus as Assessed by Continuous Glucose Monitoring System: A Pilot Study

Peterson

Chlup

Zapletalová

et al. 2010

J Diabetes Sci Technol

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Background: The purpose of this prospective open-label trial was (1) to assess the Influence of oral antidiabetic drugs (OAD) on the glycemic index (GI), glucose response curves (GRCs), daily mean plasma glucose (MPG) and (2) to compare the GI of foods in persons with OAD-treated type 2 diabetes mellitus (T2DM) with the respective GI in healthy persons (HP). Methods: Tested foods containing 50 g of carbohydrates were eaten for breakfast and dinner after 10 and 4 h of fasting, respectively. Glycemic index, GRC, and MPG were obtained using the CGMS® System Gold™ (CGMS). In T2DM patients [n = 16; age (mean ± standard error) 56.0 ± 2.25 years], foods were tested four times: tests 1, 2, and 3 were performed within one week in which placebo was introduced on day 2, and test 4 was carried out five weeks after reintroduction of OAD. Glycemic indexes, GRC, and MPG from tests 1, 2, 3, and 4 were compared. In a control group of 20 HP (age 24.4 ± 0.71 years), the mean GIs were calculated as the mean from 20 subject-related GIs. Results: In T2DM patients, subject-related assessment of GIs, GRC, and MPG distinguished persons with and without OAD effect. Nevertheless, the group-related GIs and the MPG on days 2, 8, and 39 showed no significant difference. There was no significant difference between the GIs in OAD-treated T2DM patients (test 4) versus HP (except in apple baby food). Glucose response curves were significantly larger in T2DM patients (test 4) versus HP. Conclusions: Determination of GRC and subject-related GI using the CGMS appears to be a potential means for the evaluation of efficacy of OAD treatment. Further studies are underway.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Calculation Of the Glycemic Index And Statistical Analysismentioning

confidence: 99%

See 2 more Smart Citations

Influence of Oral Antidiabetic Drugs on Hyperglycemic Response to Foods in Persons with Type 2 Diabetes Mellitus as Assessed by Continuous Glucose Monitoring System: A Pilot Study

Peterson

Chlup

Zapletalová

et al. 2010

J Diabetes Sci Technol

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“…At The Faculty of Medicine of Palacký University, Olomouc attempts to determine the GI started in 2004, originally using the traditional methods [4][5][6] and recently also a new method based on CGMS and Software Solutions [7][8][9][10][11][12] and DegifXL 13,14 . Until now, the GI of only 6 foodstuff s had been determined.…”

Section: Introductionmentioning

confidence: 99%

Glycaemic Index of Selected Foodstuffs in Healthy Persons

Fajkusova¹,

Jadviscokova²,

Pallayová³

et al. 2007

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Aims:The aim of this study was to determine glycaemic index (GI) of 10 popular foodstuff s/mixed meals in healthy persons.Methods: Ten tested foodstuff s and glucose standard were consumed in three replicates in the course of a defi ned 9-day meal plan: puff ed rice squares with chocolate, dark chocolate, white bread, honey and glucose for breakfast (at 7 a.m.) and dinner (at 8 p.m.); pasta with meat, fried fi sh with mashed potatoes, and buttered apricot dumplings for lunch (at 12 a.m.); wafers, puff ed spelt squares with chocolate, and tomato soup for snack (at 4 p.m.). Each portion contained 50 g of carbohydrates and was consumed within 30 minutes. Glucose concentrations were measured by means of the Continous Glucose Monitoring System (CGMS TM , Medtronic Minimed, Northridge, CA, USA). The results were processed by Solutions Software (Medtronic Minimed, Northridge, CA, USA) and DegifXL4 software, Palacký University, Olomouc, CZ. Twenty healthy persons aged 21.9 ± 1.39 y (mean ± SE), BMI 23.6 ± 0.63 kg/m 2 completed the study.Results: GI of tested foodstuff s ranged from 34.7 % (chocolate) to 105.3 % (puff ed rice squares with chocolate). There were more than tenfold diff erences between minimal and maximal values of the GI for some foodstuff s. Signifi cant interindividual diff erences were found between GIs of foodstuff s.Conclusions: In twenty healthy persons the glycaemic indexes of ten popular foodstuff s were determined, to be added to the nutritional labels in order to facilitate the optimum meal planning.

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Blood glucose response to rate of consumption of digestible carbohydrate

Whelan

Hollar

Agatston³

et al. 2010

BioFactors

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When the glycemic response to consuming digestible carbohydrate is measured, little or no attention appears to have been paid to the possible effect on this response of the rate at which the food is consumed. We compared glycemic responses when volunteers ate or drank foods containing digestible carbohydrate as rapidly as possible, or in five equal portions over 12 min. Expecting that the response would be greater when the food was consumed rapidly, we found that the responses were equally and randomly distributed between the two rates of eating. At the same time, marked differences were noted in the responses elicited when different individuals consumed the same foods, leading to an investigation of this phenomenon, published elsewhere.

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Automated Computation of Glycemic Index for Foodstuffs Using Continuous Glucose Monitoring

Abstract: DegifXL, combined with CGM, was an efficient and effective tool for routine measurement of group- and subject-related GI.

Cited by 10 publications

References 27 publications

Influence of Oral Antidiabetic Drugs on Hyperglycemic Response to Foods in Persons with Type 2 Diabetes Mellitus as Assessed by Continuous Glucose Monitoring System: A Pilot Study

Influence of Oral Antidiabetic Drugs on Hyperglycemic Response to Foods in Persons with Type 2 Diabetes Mellitus as Assessed by Continuous Glucose Monitoring System: A Pilot Study

Glycaemic Index of Selected Foodstuffs in Healthy Persons

Blood glucose response to rate of consumption of digestible carbohydrate

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