Automated Delineation of the Normal Urinary Bladder on Planning CT and Cone Beam CT

Rosewall, Tara; Xie, Jiawen; Kong, Vickie; Bayley, Andrew; Chung, Peter; Currie, Geoffrey; Wheat, Janelle; Milosevic, Michael

doi:10.1016/j.jmir.2015.09.011

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…PLN and whole-bladder contours were delineated by a single observer (V.K.) on each of the 230 CBCTs by manually modifying the contour propagated from the planning CT. 28 Adaptive strategies PTVPLN remained the same, whereas PTVWB was modified for each adaptive strategy as follows:…”

Section: Methodsmentioning

confidence: 99%

Comparison of 3 image-guided adaptive strategies for bladder locoregional radiotherapy

et al. 2019

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The objective of this study was to compare the dosimetric differences of a population-based planning target volume (PTV) approach and 3 proposed adaptive strategies: plan of the day (POD), patient-specific PTV (PS-PTV), and daily reoptimization (ReOpt). Bladder patients (n = 10) were planned and treated to 46 Gy in 23 fractions with a full bladder in supine position by the standard strategy using a population-based PTV. For each patient, the adaptive strategy was executed retrospectively as follows: (1) POD-multiple distributions of various PTV sizes were generated, and the appropriate distribution based on the bladder of the day was selected for each fraction; (2) PS-PTV-population-based PTV was used for the first 5 fractions and a new PTV derived using information from these fractions was used to deliver the remaining 18 fractions; and (3) ReOpt-distribution was reoptimized for each fraction based on the bladder of the day. Daily dose was computed on all cone beam computed tomographies (CBCTs) and deformed back to the planning computed tomography (CT) for dose summation afterward. V, the volume receiving an accumulated delivered dose of 43.7 Gy (95% prescription dose), was measured for comparison. Mean V (cm) values were 1410 (standard deviation [SD]: 227), 1212 (SD: 186), 1236 (SD: 199), and 1101 (SD: 180) for standard, POD, PS-PTV, and ReOpt, respectively. All adaptive strategies significantly reduced the irradiated volume, with ReOpt demonstrating the greatest reduction compared with the standard (- 25%), followed by PS-PTV (- 16%) and POD (- 12%). The difference in the magnitude of reduction between ReOpt and the other 2 strategies reached statistical significance (p = 0.0006). ReOpt is the best adaptive strategy at reducing the irradiated volume because of its frequent adaptation based on the daily geometry of the bladder. The need to adapt only once renders PS-PTV to be the best alternative adaptive strategy.

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Section: Methodsmentioning

confidence: 99%

Comparison of 3 image-guided adaptive strategies for bladder locoregional radiotherapy

et al. 2019

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“…Comparable contouring variation to planning computed tomography (CT) can be achieved [25e27]. The image quality of CBCT is also sufficient that automatic bladder segmentation tools can be successfully applied with similar performance to manual bladder delineation [23,24].…”

Section: Target Visualisation With Online Imagingmentioning

confidence: 99%

Image-guided Adaptive Radiotherapy for Bladder Cancer

et al. 2021

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Technological advancement has facilitated patient-specific radiotherapy in bladder cancer. This has been made possible by developments in image-guided radiotherapy (IGRT). Particularly transformative has been the integration of volumetric imaging into the workflow. The ability to visualise the bladder target using cone beam computed tomography and magnetic resonance imaging initially assisted with determining the magnitude of inter-and intra-fraction target change. It has led to greater confidence in ascertaining true anatomy at each fraction. The increased certainty of dose delivered to the bladder has permitted the safe reduction of planning target volume margins. IGRT has therefore improved target coverage with a reduction in integral dose to the surrounding tissue. Use of IGRT to feed back into plan and dose delivery optimisation according to the anatomy of the day has enabled adaptive radiotherapy bladder solutions. Here we undertake a review of the stepwise developments underpinning IGRT and adaptive radiotherapy strategies for external beam bladder cancer radiotherapy. We present the evidence in accordance with the framework for systematic clinical evaluation of technical innovations in radiation oncology (R-IDEAL).

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Planned versus ‘delivered’ bladder dose reconstructed using solid and hollow organ models during prostate cancer IMRT

Rosewall

Wheat

Currie

et al. 2016

Radiotherapy and Oncology

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Automated Delineation of the Normal Urinary Bladder on Planning CT and Cone Beam CT

Cited by 4 publications

References 26 publications

Comparison of 3 image-guided adaptive strategies for bladder locoregional radiotherapy

Comparison of 3 image-guided adaptive strategies for bladder locoregional radiotherapy

Image-guided Adaptive Radiotherapy for Bladder Cancer

Planned versus ‘delivered’ bladder dose reconstructed using solid and hollow organ models during prostate cancer IMRT

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