Automated Detection of Hematological Abnormalities through Classification of Flow Cytometric Data Patterns

Rossman, Mark

doi:10.25148/etd.fi11041506

Cited by 1 publication

(1 citation statement)

References 27 publications

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“…Thus, the development of ANN-based methods seems to be of interest if applied on FCM data. 123 Actually, some applications of ANNs in FCM [124][125][126][127][128] have been reported; some authors report that for field studies, the problem of obtaining suitable training data needs, as well as the number of cell categories, is an issue. This is clearly a field that needs further research.…”

Section: Discussionmentioning

confidence: 99%

Artificial Neural Networks as Decision Support Tools in Cytopathology: Past, Present, and Future

Pouliakis

Karakitsou

Margari

et al. 2016

Biomed Eng Comput Biol

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OBJECTIVEThis study aims to analyze the role of artificial neural networks (ANNs) in cytopathology. More specifically, it aims to highlight the importance of employing ANNs in existing and future applications and in identifying unexplored or poorly explored research topics.STUDY DESIGNA systematic search was conducted in scientific databases for articles related to cytopathology and ANNs with respect to anatomical places of the human body where cytopathology is performed. For each anatomic system/organ, the major outcomes described in the scientific literature are presented and the most important aspects are highlighted.RESULTSThe vast majority of ANN applications are related to cervical cytopathology, specifically for the ANN-based, semiautomated commercial diagnostic system PAPNET. For cervical cytopathology, there is a plethora of studies relevant to the diagnostic accuracy; in addition, there are also efforts evaluating cost-effectiveness and applications on primary, secondary, or hybrid screening. For the rest of the anatomical sites, such as the gastrointestinal system, thyroid gland, urinary tract, and breast, there are significantly less efforts relevant to the application of ANNs. Additionally, there are still anatomical systems for which ANNs have never been applied on their cytological material.CONCLUSIONSCytopathology is an ideal discipline to apply ANNs. In general, diagnosis is performed by experts via the light microscope. However, this approach introduces subjectivity, because this is not a universal and objective measurement process. This has resulted in the existence of a gray zone between normal and pathological cases. From the analysis of related articles, it is obvious that there is a need to perform more thorough analyses, using extensive number of cases and particularly for the nonexplored organs. Efforts to apply such systems within the laboratory test environment are required for their future uptake.

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