Automated electrical stimulation and recording for retina implant research by LabVIEW configured standalone data acquisition device

Heil, R.; Schloesser, Mario; Offenhäusser, Andreas; Waasen, S. van; Schiek, M.

doi:10.1109/sice.2014.6935289

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…Außerdem könnte man in Arealen, in denen gar keine Spontanaktivität retinaler Ganglienzellen mehr besteht, auf die Stimulation verzichten um so insbesondere bei Implantaten mit sehr vielen Elektroden die notwendige Energie auf die Elektroden zu konzentrieren, an denen eine entsprechende Stimulation auch erfolgreich ist. Die Realisierung derartiger bidirektionaler Implantate ist extrem komplex, weil die elektronischen Schaltungen zur Realisierung beider Funktionalitäten sehr unterschiedlich sind und die Registrierung schwacher Signale aus der Netzhaut extrem störanfällig ist [33][34][35]. In der Arbeitsgruppe des Autors werden an der RWTH Aachen 3-dimensionale Elektrodenkonstrukte aufgebaut, die eine Ableitung und Stimulation ent-lang des vertikalen Informationsflusses der Netzhaut erlauben (vgl.…”

Section: Bidirektionales Implantat Z B Bimea-projektunclassified

Zukünftige Entwicklungen bei implantierbaren Netzhautprothesen

Walter

2016

Klin Monatsbl Augenheilkd

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Implantable retinal prostheses for the blind are already in use. In blind subjects suffering from retinitis pigmentosa (RP), these systems are able to induce phosphenes. However, the measurable gain in vision is limited. This is due to degeneration in the retina itself and to the technology, which is used in the currently available systems. Research groups and companies are working on solutions and prototypes to improve the outcome of electrical stimulation in the visual system. One improvement will be to enlarge the electrode array in order to restore a larger visual field. A second approach is to enlarge the number of electrodes and to place them at a higher density to improve the spatial resolution of the system. A third concept is to develop a recording unit within the electrode array to analyse ganglion cell behaviour underneath the electrode. This information can than be used to optimise the stimulation pattern. Not only retinal prostheses are under development but also systems to stimulate the retina from the suprachoroidal space, to directly stimulate the optic nerve or the lateral geniculate body or even the primary visual cortex.

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Section: Bidirektionales Implantat Z B Bimea-projektunclassified

Zukünftige Entwicklungen bei implantierbaren Netzhautprothesen

Walter

2016

Klin Monatsbl Augenheilkd

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“…With the aim to facilitate the improvement and adjustment of ES parameters in retinal implants and to provide means to examine in real-time the electrical activity within the retina, a bidirectional communication strategy between retinal cells and a prosthetic device using a penetrating MEA has been proposed (Heil et al, 2014; Brusius, 2015; Walter, 2016). In this way, the possibility for simultaneous recording and stimulation is opened.…”

Section: Introductionmentioning

confidence: 99%

Toward a Bidirectional Communication Between Retinal Cells and a Prosthetic Device – A Proof of Concept

et al. 2019

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Background: Significant progress toward the recovery of useful vision in blind patients with severe degenerative retinal diseases caused by photoreceptor death has been achieved with the development of visual prostheses that stimulate the retina electrically. However, currently used prostheses do not provide feedback about the retinal activity before and upon stimulation and do not adjust to changes during the remodeling processes in the retina. Both features are desirable to improve the efficiency of the electrical stimulation (ES) therapy offered by these devices. Accordingly, devices that not only enable ES but at the same time provide information about the retinal activity are beneficial. Given the above, a bidirectional communication strategy, in which inner retinal cells are stimulated and the output neurons of the retina, the ganglion cells, are recorded using penetrating microelectrode arrays (MEAs) is proposed. Methods: Custom-made penetrating MEAs with four silicon-based shanks, each one with three or four iridium oxide electrodes specifically designed to match retinal dimensions were used to record the activity of light-adapted wildtype mice retinas and degenerated retinas from rd10 mice in vitro. In addition, responses to high potassium concentration and to light stimulation in wildtype retinas were examined. Furthermore, voltage-controlled ES was performed. Results: The spiking activity of retinal ganglion cells (RGCs) was recorded at different depths of penetration inside the retina. Physiological responses during an increase of the extracellular potassium concentration and phasic and tonic responses during light stimulation were captured. Moreover, pathologic rhythmic activity was recorded from degenerated retinas. Finally, ES of the inner retina and simultaneous recording of the activity of RGCs was accomplished. Conclusion: The access to different layers of the retina with penetrating electrodes while recording at the same time the spiking activity of RGCs broadens the use and the

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Design of a novel stimulation system with time-varying paradigms for investigating new modes of high frequency stimulation in brain

Cai

Feng

et al. 2018

BioMed Eng OnLine

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BackgroundDeep brain stimulation (DBS) has shown wide clinical applications for treating various disorders of central nervous system. High frequency stimulation (HFS) of pulses with a constant intensity and a constant frequency is typically used in DBS. However, new stimulation paradigms with time-varying parameters provide a prospective direction for DBS developments. To meet the research demands for time-varying stimulations, we designed a new stimulation system with a technique of LabVIEW-based virtual instrument.MethodsThe system included a LabVIEW program, a NI data acquisition card, and an analog stimulus isolator. The output waveforms of the system were measured to verify the time-varying parameters. Preliminary animal experiments were run by delivering the HFS sequences with time-varying parameters to the hippocampal CA1 region of anesthetized rats.ResultsVerification results showed that the stimulation system was able to generate pulse sequences with ramped intensity and hyperbolic frequency accurately. Application of the time-varying HFS sequences to the axons of pyramidal cells in the hippocampal CA1 region resulted in neuronal responses different from those induced by HFS with constant parameters. The results indicated important modulations of time-varying stimulations to the neuronal activity that could prevent the stimulation from inducing over-synchronized firing of population neurons.ConclusionsThe stimulation system provides a useful technique for investigating diverse stimulation paradigms for the development of new DBS treatments.

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Automated electrical stimulation and recording for retina implant research by LabVIEW configured standalone data acquisition device

Cited by 3 publications

References 3 publications

Zukünftige Entwicklungen bei implantierbaren Netzhautprothesen

Zukünftige Entwicklungen bei implantierbaren Netzhautprothesen

Toward a Bidirectional Communication Between Retinal Cells and a Prosthetic Device – A Proof of Concept

Design of a novel stimulation system with time-varying paradigms for investigating new modes of high frequency stimulation in brain

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