2015
DOI: 10.1016/j.apradiso.2015.06.034
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Automated electrophilic radiosynthesis of [18F]FBPA using a modified nucleophilic GE TRACERlab FXFDG

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Cited by 9 publications
(7 citation statements)
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“…The preferred l -BPA-to-F 2 ratio is > 2 for the steady production of l -[ 18 F]FBPA. It is emphasized that the synthesis time (32 min) was the shortest compared with those in previous reports: 50 min [ 27 ], 72 min [ 26 ], 80 min [ 1 ], 88 min [ 25 ], and 110 min [ 24 ].…”
Section: Resultsmentioning
confidence: 90%
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“…The preferred l -BPA-to-F 2 ratio is > 2 for the steady production of l -[ 18 F]FBPA. It is emphasized that the synthesis time (32 min) was the shortest compared with those in previous reports: 50 min [ 27 ], 72 min [ 26 ], 80 min [ 1 ], 88 min [ 25 ], and 110 min [ 24 ].…”
Section: Resultsmentioning
confidence: 90%
“…The second and third routes used the 18 O(p,n) 18 F nuclear reaction for carrier-added [ 18 F]F 2 production. In the former, [ 18 F]F 2 was produced by proton irradiation of highly enriched [ 18 O]O 2 gas followed by a second proton irradiation step for the release of [ 18 F]F 2 [ 25 , 26 ]. In the latter, [ 18 F]fluoride produced by proton irradiation of [ 18 O]H 2 O was converted to [ 18 F]F 2 via [ 18 F]fluoromethane [ 27 ].…”
Section: Introductionmentioning
confidence: 99%
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“…This 18 F–F 2 can be produced using even a small proton-only accelerator. Thus, the activity yields of 18 F-FBPA were improved greatly: 2000–5300 MBq [ 19 , 33 (seemed to use BPA containing naturally abundant 10/11 B-boron for 18 F-FBPA synthesis)]. The third route using 18 O–H 2 O-derived 18 F–F 2 achieved the highest molar activity 3700 MBq/µmol, but the activity yield of 18 F-FBPA did not seem to be improved [ 34 , 35 ].…”
Section: Radiosynthesis Of 18 F-fbpamentioning
confidence: 99%