With the robust development of Artificial Intelligence (AI), especially image processing has made information technology more efficient and effective in the sense to evaluate facial features, even though there has been masked on the face. However, the accuracy of acne detection and related severity analysis is becoming a significant prospect for the precise treatment of patients. Due to this, close severity is one of the features that need to be added first, while it is considered a highly challenging aspect for dermatologists because the similar appearance of acne in the face reduces the rate of accuracy when examining. It poses a serious problem in the domain of biomedical processing and controls. In this paper, we contribute to four different folds. Initially, this paper presents a novel framework that provides a platform in order to measure localization and segmentation. In this process, consultants receive better accuracy and efficiency during the process of acne detection and severity analysis. Second, this paper utilizes deep neural networks (DNNs) as a backend process to lightning the extraction of multi-scale features through a multi-hierarchy neural net for regionalized facial features to investigate distinction and localization. Third, a class-based segmentation approach customizes and integrates with the proposed framework to examine the background and facial skin separation to distinguish different classes to obtain severity marking. Fourth, the facial skin segmentation classes are built as a cluster segment using Generative Adversarial Network (GAN). It provides a high-resolution network that enhances severity masking awareness and related attentions, including shuffle and conditional channels like an update in weight block. Although, the simulation illustrates that the technological collaboration achieves promising results and elaborates on the accuracy and efficiency while the detection of acne as compared to other state-of-the-art baseline methods. In addition, the proposed framework illustrates good results in severity analysis for acne detection comparably far better than the previously published articles with a performance rate of 3.112% (accuracy), 1.131% (segmentation), 2.317% (localization), and 1.573% (GAN-based high-resolution network management), respectively.