Because of its high efficiency, low pollution, energy saving and other technical advantages, CFB boiler has been rapidly promoted commercially in recent decades. However, because of its special combustion mode and high material concentration, the gas-solid two-phase flow is more complex and the wear is more serious. No matter in theoretical research or engineering practice, the problem of serious wear and tear of CFB boiler has not been completely solved. Wear is the main reason that restricts the further development of CFB boilers. The main purpose of this paper is to study the application of anti-wear technology of water-cooled wall of CFB boiler. Therefore, this paper makes a systematic study on the serious wear problem of CFB boiler, makes an accurate prediction of the serious wear area, and puts forward comprehensive anti-wear measures to slow down the wear rate and prolong the service life. Through experiment, numerical simulation and comparison with the field practice, the study shows that the wear of water wall is mainly divided into erosion wear, friction wear and high temperature atmosphere corrosion wear. Among them, the wear of water-cooled wall (WCW) is mainly erosion and friction wear, while the corrosion wear of high temperature atmosphere accelerates the speed of these two kinds of wear.