Automated image analysis of hand radiographs reveals widened joint spaces in patients with long-term control of acromegaly: relation to disease activity and symptoms

Abstract

Objective: Arthropathy is an invalidating complication of acromegaly. Although acromegalic arthropathy shares features with primary osteoarthritis, joint spaces are widened rather than narrowed in patients with long-term cure of acromegaly. The late effects of acromegaly on hand joints have not been characterized. Therefore, the objective of the current study was to assess joint space widths (JSWs) of hand joints in patients with long-term control of acromegaly and to identify factors associated with JSW. Methods: A cross-sectional study was carried out in 89 patients (age 58G12 years, 49% women) with long-term controlled acromegaly and 471 controls without hand symptoms (age 46G12 years, 42% women). Radiological JSWs of individual hand joints were measured by automated image analysis. Results: Patients had wider mean joint spaces than controls: metacarpo-phalangeal (MCP) joints were w24%, proximal interphalangeal joints w21%, and distal interphalangeal joints were w20% wider (patients vs controls; P!0.001 for all joints). Mean JSW exceeded the 95th percentile of the values obtained in controls in 64% of patients. Higher IGF1 and GH concentrations at diagnosis were associated with larger JSWs (adjusted b for pretreatment GH in tertiles: 0.09 (95% confidence interval (CI) 0.03-1.84) and for IGF1 in tertiles: 0.14 (95% CI 0.05-0.23) at the MCP joints in acromegalic patients. In male patients, but not in female patients, increased JSWs were associated with more self-reported pain (PZ0.02). Conclusions: Using a new semi-automated image analysis of hand radiographs, acromegalic patients with long-term disease control appeared to have increased joint spaces of all hand joints. JSWs were positively related to disease activity at diagnosis, but not to duration of follow-up, suggesting irreversible cartilage hypertrophy. Irreversible cartilage hypertrophy may partly explain persisting hand complaints despite long-term disease control.

Expert consensus document: A consensus on the medical treatment of acromegaly

“…New techniques are needed to measure bone and joint integrity to assess better the effects of acromegaly treatment (MQ). [45][46][47][48] Different medications for acromegaly have different effects on glucose metabolism. SRLs might have a negative influence on glucose metabolism, but generally with marginal clinical relevance and most frequently in patients who do not have biochemical control of the disease.…”

Bone and Joint Disorders in Acromegaly

“…Recently, van ‘t Klooster and colleagues [70,71] have introduced a new quantitative semiautomated image analysis method of hand radiographs, which is sensitive enough to relate joint space width to markers of disease activity of acromegaly. Therefore, this method is able to fully characterize the effects of previous GH excess on joint cartilage, including the measurement of joint space widening.…”

Kavain inhibition of LPS-induced TNF-α via ERK/LITAF

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