Automated measurement and statistical modelling of elastic laminae in arteries

Xu, Hai; Hu, Jin; Humphrey, Jay D.; Liu, Jyh Charn

doi:10.1080/10255840903580033

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…Amongst others, we have proposed methods to automate such quantification. 5,19,40,45,85 In addition, advances in imaging methods such as two photon fluorescence (TPF) and second harmonic generation (SHG) in multiphoton microscopy provide important new information. 37,81 …”

Section: Experimental Methodsmentioning

confidence: 99%

Biomechanical Phenotyping of Central Arteries in Health and Disease: Advantages of and Methods for Murine Models

2013

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The stiffness and structural integrity of the arterial wall depends primarily on the organization of the extracellular matrix and the cells that fashion and maintain this matrix. Fundamental to the latter is a delicate balance in the continuous production and removal of structural constituents and the mechanical state in which such turnover occurs. Perturbations in this balance due to genetic mutations, altered hemodynamics, or pathological processes result in diverse vascular phenotypes, many of which have yet to be well characterized biomechanically. In this paper, we emphasize the particular need to understand regional variations in the biaxial biomechanical properties of central arteries in health and disease and, in addition, the need for standardization in the associated biaxial testing and quantification. As an example of possible experimental methods, we summarize testing protocols that have evolved in our laboratory over the past 8 years. Moreover, we note advantages of a four fiber family stress – stretch relation for quantifying passive biaxial behaviors, the use of stored energy as a convenient scalar metric of the associated material stiffness, and the utility of appropriate linearizations of the nonlinear, anisotropic relations both for purposes of comparison across laboratories and to inform computational fluid-solid-interaction models. We conclude that, notwithstanding prior advances, there remain many opportunities to advance our understanding of arterial mechanics and mechanobiology, particularly via the diverse genetic, pharmacological, and surgical models that are, or soon will be, available in the mouse.

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Section: Experimental Methodsmentioning

confidence: 99%

Biomechanical Phenotyping of Central Arteries in Health and Disease: Advantages of and Methods for Murine Models

2013

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“…To adapt to this trend, research in this area is very important. The emergence of the advent of high-performance microcontroller and digital signal processors promote the extensive application of the data acquisition [1].…”

Section: Introductionmentioning

confidence: 99%

Study on the Temperature and Speed Test System

Zhao

Chen

et al. 2012

AMR

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A kind of multiple parameter data acquisition system was designed based on single-chip microcomputer which can realized the data acquisition of temperature and DC motor speed. The data acquisition system consists of sensor, signal processing circuit, single-chip microcomputer and LED digital tube. The speed signal is acquired by photoelectric sensor, put into the Single-chip microcomputer processed after processed by signal processing circuit, and displayed the value in the digital tubes. The temperature signal is acquired by digital sensor, and the Single-chip microcomputer can read the data directly. Through two independent keyboards, the test system realized the data acquisition and data switch displaying of the multiple parameters.

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Automated measurement and statistical modelling of elastic laminae in arteries

Cited by 2 publications

References 34 publications

Biomechanical Phenotyping of Central Arteries in Health and Disease: Advantages of and Methods for Murine Models

Biomechanical Phenotyping of Central Arteries in Health and Disease: Advantages of and Methods for Murine Models

Study on the Temperature and Speed Test System

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