Automated Mechanical Peripheral Stimulation Effects on Gait Variability in Individuals With Parkinson Disease and Freezing of Gait: A Double-Blind, Randomized Controlled Trial

Kleiner, Ana Francisca Rozin; Pagnussat, Aline de Souza; Pinto, Camila; Marchese, Ritchele Redivo; Salazar, Ana Paula; Galli, Manuela

doi:10.1016/j.apmr.2018.05.009

Cited by 23 publications

(35 citation statements)

References 49 publications

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“…Whereas Pinto and colleagues found no difference in any gait parameter, a within‐group analysis (post hoc) found that the AMPS group significantly improved stride length, step length, and gait speed. A sequel to the study found that the same APMS protocol increased step length and walking speed and improved step variability and asymmetry.…”

Section: Resultsmentioning

confidence: 91%

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Nonpharmacological, Nonsurgical Treatments for Freezing of Gait in Parkinson's Disease: A Systematic Review

et al. 2019

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Freezing of gait is a disabling phenomenon that appears in a substantial number of Parkinson's disease (PD) patients as the disease evolves. It is considered to be one of the most relevant contributing factors to worsening of quality of life. Current pharmacological or surgical treatment options have limited efficacy. Thus, alternative nonpharmacological/nonsurgical approaches have emerged in recent years in an attempt to improve quality of life in PD. This systematic review summarizes studies of such therapies over the past 5 years. Thirty‐five studies were evaluated by use of a qualitative evaluation, while the methodological quality was assessed using validated tools. According to our results, there appear to be two broad categories of nonpharmacological therapies: those that seek a long‐lasting benefit and those that aim to achieve a transient effect to overcome the freezing of gait episode. Among the former, it is possible to differentiate between “passive” therapies, which include transcranial magnetic stimulation or transcranial direct current stimulation, and “active” therapies, which are based on different cognitive or physical training programs. Finally, “transient effect” therapies use different types of cues, such as visual, auditory, or proprioceptive stimuli, to attempt to shift the patient's habitual motor control to a goal‐directed one. In conclusion, a broad spectrum of nonpharmacological/nonsurgical approaches for freezing of gait has emerged in recent years with promising results. © 2019 International Parkinson and Movement Disorder Society

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Section: Resultsmentioning

confidence: 91%

“…APMS consists of application of mechanical pressure stimulation to target areas of the feet using a device equipped with electric motors that activate metallic stimulators . Balance and gait impairments observed in subjects with PD and FOG are closely related to sensorimotor integration deficits and decreased foot‐sole sensitivity .…”

Section: Discussionmentioning

confidence: 99%

Nonpharmacological, Nonsurgical Treatments for Freezing of Gait in Parkinson's Disease: A Systematic Review

et al. 2019

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“…AMPS therapy consists of applying a mechanical pressure with intensity to elicit pain (at pain pressure threshold) at four speci c points on the sole of the both feet of patients with PD. Moreover, the total therapy duration is 96 seconds, and some studies have reported that the effects may last up to 72 hours (22,23). Therefore, due to its promising bene cial results and that it is not a time-consuming therapy, AMPS represents an interesting intervention strategy.…”

Section: Background and Rationale {6a}mentioning

confidence: 99%

Effect Of The Combination Of Automated Peripheral Mechanical Stimulation And Physical Exercise On Aerobic Functional Capacity And Cardiac Autonomic Control: A Randomized Clinical Trial Protocol.

Zelada-Astudillo

Herrera-Santelices

Barbieri

et al. 2021

Preprint

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● Background: Automated peripheral mechanical stimulation (AMPS) has been proposed as a new complementary therapy with potential for improving motor and cardiovascular abnormalities in Parkinson's disease (PD). However, AMPS long-term effects and its combination with physical exercise is unknown. Thus, this study aims to compare the effects of a program of 12 weeks of physical exercise with a 12-week intervention program combining physical exercise and AMPS on the aerobic capacity, cardiac autonomic control and gait parameters in patients with PD.● Methods: A randomized, controlled clinical trial will be conducted. Volunteers will be randomly assigned to one of the two groups studied: 1) Exercise; or 2) AMPS + Exercise. Both groups will undergo an exercise program of 24 sessions, for 12 weeks, performed twice a week. Before exercise sessions, the group AMPS+Exercise will receive a session of active AMPS, while the group Exercise will receive an AMPS sham intervention. Shapiro-wilk’s and Levene’s tests will be used to check for data normality and homogeneity, respectively. In case parametric assumptions are fulfilled, per-protocol and intention-to-treat analyses will be performed using a mixed model analysis of variance to check for Group*Time interaction. Significance level will be set at 5%. ● Discussion: Several non-pharmacological treatment modalities have been proposed for PD, focusing primarily on the reduction of motor and musculoskeletal disorders. Regular exercise and motor training have been shown to be effective in improving quality of life. However, treatment options in general remain limited given the high prevalence and adverse impact of these disorders. So, developing new strategies that can potentiate the improvement of motor disabilities and also improve non-motor symptoms in PD is relevant. It is expected that the participants from both groups will improve their quality of life, gait parameters and their cardiac autonomic control, with greater improvements being observed in the group combining active AMPS and physical exercise.Trial registration: ClinicalTrials.gov, NCT04251728, registered February 05, 2020

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“…The most common beneficial effects of mechanical plantar stimulation reported were gait velocity (reported in seven studies: [55,57,60,[62][63][64][65]), stride length (reported in 6 studies: [55,56,59,60,63,64]) and step length (reported in five studies [57,61,62,64,65]) ( Table 3). However other parameters less extensively investigated in the gait analysis also improved after plantar foot stimulation, including step variability (reported in two studies [57,62]), asymmetry and pitch contact (reported in 1 study [56]) ( Table 3). An important issue for understanding how this intervention acts is the reporting of gait parameters that did not improve walking speed [56,59].…”

Section: Effects Of Plantar Foot Stimulation On Various Parameters Rementioning

confidence: 99%

“…Kleiner et al (2018) [62] Gait was assessed at baseline and after the first, fourth and eight treatment session in a movement analysis laboratory with a gait analysis using a three-dimensional optoelectronic system. Improvements in gait asymmetry, step length, step time, gait velocity, step length standard deviation and step time standard deviation.…”

Section: Effect Of Mps On Spatio-temporal Gait and Postural Control Pmentioning

confidence: 99%

Mechanical Plantar Foot Stimulation in Parkinson′s Disease: A Scoping Review

Brognara

Cauli

2020

Diseases

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Background: Parkinson′s disease (PD) is the second most prevalent neurodegenerative disease in older individuals. Neurorehabilitation-based interventions such as those improving gait are crucial for a holistic approach and to limit falls. Several studies have recently shown that mechanical plantar foot stimulation is a beneficial intervention for improving gait impairment in PD patients. The objective of this scoping review is to evaluate the beneficial effects of this stimulation on gait parameters, and to analyse protocols of foot stimulation and other effects in non-motor symptoms. Relevant articles were searched in the Medline database using Pubmed and Scopus, using the primary search terms ‘foot stimulation’ OR ‘plantar stimulation’ AND ‘Parkinson’s disease*’. Several protocols have been used for mechanical plantar foot stimulation (ranging from medical devices to textured insoles). The gait parameters that have been shown to be improved are stride length and walking speed. The beneficial effects are achieved after both acute and repeated plantar foot stimulation. Beneficial effects are observed in other organs and systems, such as muscle activation, brain connectivity, cardiovascular control in the central nervous system, and the release of brain-derived neurotrophic factor and cortisol in blood added evidence about this intervention’s impact on brain function. Mechanical plantar foot stimulation is a safe and effective add-on treatment able for improving gait impairments in PD patients during the L-dopa off state. Randomized and controlled clinical trials to study its eventual potentiating effect with different pharmacotherapy regimens are warranted.

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Automated Mechanical Peripheral Stimulation Effects on Gait Variability in Individuals With Parkinson Disease and Freezing of Gait: A Double-Blind, Randomized Controlled Trial

Cited by 23 publications

References 49 publications

Nonpharmacological, Nonsurgical Treatments for Freezing of Gait in Parkinson's Disease: A Systematic Review

Nonpharmacological, Nonsurgical Treatments for Freezing of Gait in Parkinson's Disease: A Systematic Review

Effect Of The Combination Of Automated Peripheral Mechanical Stimulation And Physical Exercise On Aerobic Functional Capacity And Cardiac Autonomic Control: A Randomized Clinical Trial Protocol.

Mechanical Plantar Foot Stimulation in Parkinson′s Disease: A Scoping Review

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