Automated Melasma Area and Severity Index scoring

Silpa‐archa, Narumol; Kohli, Indermeet; Al‐Jamal, Mohammed; Hamzavi, Iltefat

doi:10.1111/bjd.13840

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…From a clinical point of view, laser‐assisted or mechanical dermabrasion seems to be beneficial in association with standard treatments with topical steroids and NB‐UVB in resistant vitiligo patients . Dermoabrasion and fractional CO 2 laser are also considered to be two alternative methods to prepare the recipient site for cell suspension transplantation procedure . The biological rationale for the use of PRP involves the local delivery of growth factors, immune system messengers and molecules capable of inducing cellular proliferation, collagen synthesis and extracellular matrix remodelling favouring fibroblast migration .…”

Section: Introductionmentioning

confidence: 99%

“…[21] Dermoabrasion and fractional CO 2 laser are also considered to be two alternative methods to prepare the recipient site for cell suspension transplantation procedure. [22][23][24][25][26] The biological rationale for the use of PRP involves the local delivery of growth factors, immune system messengers and molecules capable of inducing cellular proliferation, collagen synthesis and extracellular matrix remodelling favouring fibroblast migration. [27] Although experimental data related to PRP are of interest, there are only very few inconclusive studies performed on vitiligo patients in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Extracellular fraction of adipose tissue as an innovative regenerative approach for vitiligo treatment

Bellei

Papaccio

Filoni

et al. 2019

Experimental Dermatology

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Vitiligo is a common, disfiguring autoimmune disease that negatively affects patients’ self‐esteem and quality of life. Current treatments are moderately effective in reversing disease and promoting melanocyte regeneration. Thus, therapeutic advanced strategies are emerging from regenerative medicine. It has recently emerged that adipose tissue secretome may be used as a cell‐free therapy in skin regeneration since paracrine functions of adipose‐derived stem cells alone are responsible for most of the therapeutic effect of stem cells in several animal disease models. In this study, we tested the effect of adipose tissue extracellular fraction (AT‐Ex) isolated from lipoaspirates on dermal and epidermal vitiligo cells in vitro. Using this experimental model, we demonstrated that molecules secreted by adipose tissue ameliorate the capability to counteract oxidative stress by a physiological stimulation of intracellular antioxidant enzymes and positively impact on cell proliferation. Due to the presence of Wnt‐secreted factors, AT‐Ex treatment promotes glycogen synthase kinase 3β inactivation and consequently Wnt/β‐catenin pathway activation. Collectively, our findings show that AT‐Ex could be useful as a natural approach to improve treatment of vitiligo.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Extracellular fraction of adipose tissue as an innovative regenerative approach for vitiligo treatment

Bellei

Papaccio

Filoni

et al. 2019

Experimental Dermatology

View full text Add to dashboard Cite

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Efficacy of Microneedle as an Assisted Therapy for Melasma: A Meta-analysis and Systematic Review of Randomized Controlled Trials

Simin,

Siliang,

Wei

et al. 2024

Aesth Plast Surg

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Background Melasma is a common hyperpigmentary disorder, it has variety of treatment options, but it usually has a poor curative effect and high recurrence rate. Microneedles have shown certain prospects in the treatment of melasma as an assisted therapy, but there is no consensus on its efficacy and safety. To evaluate the efficacy and safety of microneedles as an adjuvant treatment for melasma. Methods Statistical tools were used to adjust the improvement of MASI scores in all studies to obtain standardized mean differences (SMD), and then, meta-analysis were performed. Risk ratio (RR) was utilized to assess adverse reactions, clinical effectiveness, and patient satisfaction. Results The effects of microneedle-assisted treatment for melasma begin to manifest at the 4th week, with optimal results observed at the 24th week, and with a high patient satisfaction. Compared with oral medication alone, microneedle-assisted therapy began to be more effective at week 12 and continued by 24 weeks. Compared with laser therapy alone, microneedle-assisted therapy also showed stronger efficacy, at the 8th week, microneedle-assisted treatment was significantly more effective, reaching its peak at the 12th week. Finally, in the comparison of microneedle and microinjection therapy, microneedle has always been more significant than micro-injection. Conclusions Microneedle is a valuable adjunctive therapy for melasma treatment. It enhances long-term clinical outcomes compared to monotherapy and is associated with high patient satisfaction. Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Automated Melasma Area and Severity Index scoring

Cited by 2 publications

References 6 publications

Extracellular fraction of adipose tissue as an innovative regenerative approach for vitiligo treatment

Extracellular fraction of adipose tissue as an innovative regenerative approach for vitiligo treatment

Efficacy of Microneedle as an Assisted Therapy for Melasma: A Meta-analysis and Systematic Review of Randomized Controlled Trials

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