“…For example, deterministic skeletonization algorithms estimate an object's medial geometry directly from its boundary representation (e.g., [61][62][63]), while inverse skeletonization algorithms approximate an object's medial geometry by fitting a pre-defined deformable model with fixed medial topology to the object (e.g., [64,65]). In this work, we use a boundary contour resampling scheme adapted from [66] to generate a 3D triangulated medial mesh of the aortic root based on the geometry of its boundary (similar to deterministic algorithms) while assuming a non-branching medial 8 axis topology (similar to inverse skeletonization approaches). The meshing algorithm is specific to 3D shapes with non-branching medial geometry, meaning that the 3D shape can be sliced into 2D cross-sections that are oblong and homeomorphic to a disk (e.g., placentas, cardiac ventricles, kidneys).…”