Automated motion artifact correction for dynamic contrast-enhanced fluorescence imaging during open orthopedic surgery

Tang, Yue; Gitajn, Ida Leah; Cao, Xu; Han, Xinyue; Elliott, Jonathan T.; Yu, Xiaohan; Bateman, Logan M.; Malskis, Bethany S.; Fisher, Lillian A.; Sin, Jessica M.; Henderson, Eric; Pogue, Brian W.; Jiang, Shudong

doi:10.1117/12.2650028

Molecular-Guided Surgery: Molecules, Devices, and Applications IX 2023

DOI: 10.1117/12.2650028

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Automated motion artifact correction for dynamic contrast-enhanced fluorescence imaging during open orthopedic surgery

Yue Tang

Ida Leah Gitajn

Xu Cao

et al.

Abstract: Indocyanine green (ICG)-based dynamic contrast-enhanced fluorescence imaging (DCE-FI) can objectively assess bone perfusion intraoperatively. However, it is susceptible to motion artifacts due to patient’s involuntary respiration during the 4.5-minute DCE-FI data acquisition. An automated motion correction approach based on mutual information (MI) frame-by-frame was developed to overcome this problem. In this approach, MIs were calculated between the reference and the adjacent frame translated and the maximal … Show more

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2024

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Cited by 2 publications

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Automatic correction of motion artifact in dynamic contrast-enhanced fluorescence imaging during open orthopedic surgery

Tang,

Gitajn,

Cao

et al. 2024

J. Biomed. Opt.

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Indocyanine green-based dynamic contrast-enhanced fluorescence imaging (DCE-FI) can objectively assess bone perfusion intraoperatively. However, it is susceptible to motion artifact due to patients' involuntary respiration and mechanical disturbance. Reducing motion artifacts would significantly improve DCE-FI for orthopedic surgical guidance.Aim: Our primary objective is to develop an automated correction method to reduce motion artifacts in DCE-FI and improve the accuracy of bone perfusion assessment. Approach:We developed an automated motion correction approach based on frame-by-frame mutual information (MI) and validated the effectiveness of this approach in various phantom studies and patient images from 45 imaging sessions of fifteen amputees. Results:The MI-based correction reduced motion artifacts by 93% for mechanical disturbances and 76% for simulated respiration in phantom studies. Patient images show improved alignment, improved kinetic curves, and restored bone perfusionrelated parameters with an average correction of 4.3 and 9.6 mm in x -and y -axes per session. Conclusions:The automated MI-based motion correction was able to eliminate motion artifacts effectively and significantly improved the quantitative assessment of bone perfusion by DCE-FI.

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Automatic correction of motion artifact in dynamic contrast-enhanced fluorescence imaging during open orthopedic surgery

Tang,

Gitajn,

Cao

et al. 2024

J. Biomed. Opt.

Self Cite

View full text Add to dashboard Cite

show abstract

Dead or alive — use of indocyanine green angiography for intraoperative assessment of bone vitality in nonunion fractures: a controlled case series of four patients

Malagoli,

Vandenbulcke,

Ziadi

et al. 2024

Traumatology and Orthopedics of Russia

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Background. Indocyanine green (ICG) fluorescence imaging is a surgical tool with increasing applications in various surgical disciplines. During nonunion resection, the assessment of bone vascularization is currently based only on the surgeon’s experience. We introduced the use of indocyanine green (ICG) angiography in orthopedics. The aims of the study: 1) to use ICG fluorescence angiography to evaluate the bone perfusion in patients with atrophic nonunion, where poor or absent ICG flow reveals avascular tissue associated with bone necrosis requiring surgical resections; 2) to describe our case series of patients operated with this technique. Methods. We used ICG angiography in patients operated for tibial nonunion resection. We administered 0.5 mg/kg of ICG powder dissolved in sterile saline at 2.5 mg/ml concentration. The time from the injection to the beginning of appreciation of the green dye was measured. Non-viable bone was resected accordingly. Patient underwent routine follow-up. We enrolled all the suitable patients operated from April 2019 to June 2021 and matched three control patients for each of them. We reviewed their medical records and noted any relevant data. Results. We enrolled 4 cases and 12 controls, all male. The mean age was 30.8±6.9 years. The mean duration from trauma to surgery was 10.5 (0.7-25.0) months. The mean duration of surgery was 190.8±40.3 min. The defect size was 4.89±2.03 cm. ICG allowed rapid visualization of bone vascularization after 25-45 sec. No adverse events were observed. The mean external fixation time was 11.8±5.0 months. The mean external fixation index was 2.69±1.10. Seven patients needed a surgical revision during treatment. Three patients underwent reintervention after frame removal. There are no statistically significant differences between cases and controls. Conclusions. The research findings of this study are limited by the small number of observations. However, this technique is safe, easy, and rapid and may contribute to intraoperative decision of how much to resect. Using ICG could objectively demonstrate bone perfusion to help surgeons to avoid massive bone defects.

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Automated motion artifact correction for dynamic contrast-enhanced fluorescence imaging during open orthopedic surgery

Cited by 2 publications

References 13 publications

Automatic correction of motion artifact in dynamic contrast-enhanced fluorescence imaging during open orthopedic surgery

Automatic correction of motion artifact in dynamic contrast-enhanced fluorescence imaging during open orthopedic surgery

Dead or alive — use of indocyanine green angiography for intraoperative assessment of bone vitality in nonunion fractures: a controlled case series of four patients

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