Automated on-line liquid–liquid extraction system for temporal mass spectrometric analysis of dynamic samples

Prototyping Instruments for the Chemical Laboratory Using Inexpensive Electronic Modules

“…Moreover,a utomating laboratory procedures and integrating them with online data-logging systems can improve reproducibility.C hanges in the laboratoryse nvironmental conditions (temperature,h umidity) can affect the performance of research protocols. [22] By fitting the laboratory space with simple electronic modules,the environmental conditions in the laboratory can be recorded over long periods of time and then correlated with the results.I nstrumentation can be wirelessly controlled through MCBs and SBCs fitted with Bluetooth [8,23] or Wifi [13] transmitters.T his allows chemists to receive updates on their experiments even if they are away. Perhaps the most radical example of information technologyaided chemistry is "cloud chemistry" whereby the operations in aw et chemistry laboratory are supervised by ac hemist located thousands of kilometers away.…”

“…In an automated extraction system developed in our laboratory,s everal actuators (peristaltic pump,e lectromagnet) and detectors (color sensor,m ass spectrometer) were operated through acontrol unit comprising several universal electronic modules (Arduino,N etduino;S upporting Information, Figure S2). [13] Them odules were programmed in C+ ++ + and C#. They guided the transfer of the sample to aminiature extraction chamber.…”

Prototypen‐Entwicklung von Instrumenten für das chemische Laboratorium mithilfe von preiswerten Elektronikmodulen

“…Wir entwickelten ein automatisches Extraktionssystem, in dem mehrere Effektoren (eine peristaltische Pumpe, ein Elektromagnet) und Detektoren (Farbsensor, Massenspektrometer) durch eine Kontrolleinheit aus mehreren universellen Elektronikmodulen (Arduino, Netduino; Hintergrundinformationen, Abbildung S2) gesteuert werden . Die Module wurden in C++ und C# programmiert.…”

“…Stattet man das Labor mit einfachen Elektronikmodulen aus, kann man die Umweltbedingungen über einen langen Zeitraum hinweg beobachten und diese Daten dann mit den Ergebnissen korrelieren. Eine kabellose Steuerung und Überwachung der Laborinstrumente ist über Bluetooth oder WLAN mit entsprechend ausgestatteten MCBs und SBCs möglich. Der Chemiker erhält jederzeit aktuelle Daten über den Fortgang der Versuche, auch wenn er nicht im Labor ist.…”

The quest for improved reproducibility in MALDI mass spectrometry

“…The last few years have seen great advances in electronics and rapid prototyping driven by the “Maker Community.” Individuals or groups are able to use cheap microcontrollers, such as Arduino, or more sophisticated but still cheap single board computers, such as Raspberry Pi, to create sophisticated robotics. This is of immediate attraction to researchers as these open source platforms are easily adapted to the creation of scientific instrumentation, such as thermocyclers (Kalaitzis et al, ) and on‐line liquid–liquid extraction (Hsieh, Liu, & Urban, ). Of immediate relevance to this review is the work of Stoeckli & Staab () who have created a matrix deposition device for imaging mass spectrometry (iMatrixSpray, http://imatrixspray.com) from easily sourced and cost effective parts.…”